Chemical constituents from the fruits of Schisandra sphenanthera and their cytotoxicity activity

Hee Jae Kwak, Seon Ju Park, Guijae Yoo, Jun Hyung Park, Youngse Oh, Mira Oh, Nguyen Xuan Nhiem, Yun Na Kim, Eun Ju Jeong, Seung Hyun Kim

Research output: Contribution to journalArticle

Abstract

Schisandra sphenanthera Rehder & E.H. Wilson, Schisandraceae, is well known as a type of traditional medicine for the treatment of hepatitis, diarrhea and insomnia in Asia. It was also reported to have antiviral and anti-HIV activities. Using various chromatographic resins and isolation techniques, a new lignan (1), erythro-4-(3,4-dimethoxyphenyl)-4-hydroxy-3-methylbutan-2yl-3,4-dimethoxybenzoate, along with fifteen known compounds, were isolated from fruits of S. sphenanthera. The structures of the compounds were identified by extensive spectroscopic and spectrometric methods including 1D and 2D NMR and MS data. All the isolated compounds were evaluated for their cytotoxicity activity against Hela, HepG2 and HCT-116 cells. Among them, compound schisanlactone C showed significant cytotoxicity activity.

Original languageEnglish
Pages (from-to)578-581
Number of pages4
JournalBrazilian Journal of Pharmacognosy
Volume29
Issue number5
DOIs
Publication statusPublished - 2019 Sep 1

Fingerprint

Schisandraceae
Schisandra
HCT116 Cells
Lignans
Sleep Initiation and Maintenance Disorders
Traditional Medicine
Hepatitis
Antiviral Agents
Diarrhea
Fruit
HIV
Therapeutics

All Science Journal Classification (ASJC) codes

  • Pharmacology, Toxicology and Pharmaceutics(all)

Cite this

Kwak, Hee Jae ; Park, Seon Ju ; Yoo, Guijae ; Park, Jun Hyung ; Oh, Youngse ; Oh, Mira ; Nhiem, Nguyen Xuan ; Kim, Yun Na ; Jeong, Eun Ju ; Kim, Seung Hyun. / Chemical constituents from the fruits of Schisandra sphenanthera and their cytotoxicity activity. In: Brazilian Journal of Pharmacognosy. 2019 ; Vol. 29, No. 5. pp. 578-581.
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abstract = "Schisandra sphenanthera Rehder & E.H. Wilson, Schisandraceae, is well known as a type of traditional medicine for the treatment of hepatitis, diarrhea and insomnia in Asia. It was also reported to have antiviral and anti-HIV activities. Using various chromatographic resins and isolation techniques, a new lignan (1), erythro-4-(3,4-dimethoxyphenyl)-4-hydroxy-3-methylbutan-2yl-3,4-dimethoxybenzoate, along with fifteen known compounds, were isolated from fruits of S. sphenanthera. The structures of the compounds were identified by extensive spectroscopic and spectrometric methods including 1D and 2D NMR and MS data. All the isolated compounds were evaluated for their cytotoxicity activity against Hela, HepG2 and HCT-116 cells. Among them, compound schisanlactone C showed significant cytotoxicity activity.",
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Kwak, HJ, Park, SJ, Yoo, G, Park, JH, Oh, Y, Oh, M, Nhiem, NX, Kim, YN, Jeong, EJ & Kim, SH 2019, 'Chemical constituents from the fruits of Schisandra sphenanthera and their cytotoxicity activity', Brazilian Journal of Pharmacognosy, vol. 29, no. 5, pp. 578-581. https://doi.org/10.1016/j.bjp.2019.05.006

Chemical constituents from the fruits of Schisandra sphenanthera and their cytotoxicity activity. / Kwak, Hee Jae; Park, Seon Ju; Yoo, Guijae; Park, Jun Hyung; Oh, Youngse; Oh, Mira; Nhiem, Nguyen Xuan; Kim, Yun Na; Jeong, Eun Ju; Kim, Seung Hyun.

In: Brazilian Journal of Pharmacognosy, Vol. 29, No. 5, 01.09.2019, p. 578-581.

Research output: Contribution to journalArticle

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AU - Kwak, Hee Jae

AU - Park, Seon Ju

AU - Yoo, Guijae

AU - Park, Jun Hyung

AU - Oh, Youngse

AU - Oh, Mira

AU - Nhiem, Nguyen Xuan

AU - Kim, Yun Na

AU - Jeong, Eun Ju

AU - Kim, Seung Hyun

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