Chemical constituents from the stem bark of Albizia julibrissin and their SREBP-1c inhibitory activity

Meiling Xian; Mira Oh; Hee Jae Kwak; Hyunjin Jeong; Hyun Jeong Ko; Seung Hyun Kim

doi:10.1080/10286020.2022.2163633

Chemical constituents from the stem bark of Albizia julibrissin and their SREBP-1c inhibitory activity

Meiling Xian, Mira Oh, Hee Jae Kwak, Hyunjin Jeong, Hyun Jeong Ko, Seung Hyun Kim

Department of Pharmacy

Research output: Contribution to journal › Article › peer-review

Abstract

One new lignan, julibrissinoside II, along with thirteen known compounds, was isolated from the stem bark of Albizia julibrissin. The structure of julibrissinoside II was determined on the basis of extensive spectroscopic methods, including NMR and CD spectroscopic data. The isolated compounds were tested for their SREBP-1c inhibitory activity at different concentrations using mouse hepatocyte AML12 cell lines. Among them, linoleic acid (2) and 3-O-methylfisetin (4) showed significant SREBP-1c inhibitory activity at the concentration of 100 µM.

Original language	English
Journal	Journal of Asian Natural Products Research
DOIs	https://doi.org/10.1080/10286020.2022.2163633
Publication status	Accepted/In press - 2023

Bibliographical note

Publisher Copyright:
© 2023 Informa UK Limited, trading as Taylor & Francis Group.

All Science Journal Classification (ASJC) codes

Analytical Chemistry
Molecular Medicine
Pharmacology
Pharmaceutical Science
Drug Discovery
Complementary and alternative medicine
Organic Chemistry

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10.1080/10286020.2022.2163633

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title = "Chemical constituents from the stem bark of Albizia julibrissin and their SREBP-1c inhibitory activity",

abstract = "One new lignan, julibrissinoside II, along with thirteen known compounds, was isolated from the stem bark of Albizia julibrissin. The structure of julibrissinoside II was determined on the basis of extensive spectroscopic methods, including NMR and CD spectroscopic data. The isolated compounds were tested for their SREBP-1c inhibitory activity at different concentrations using mouse hepatocyte AML12 cell lines. Among them, linoleic acid (2) and 3-O-methylfisetin (4) showed significant SREBP-1c inhibitory activity at the concentration of 100 µM.",

author = "Meiling Xian and Mira Oh and Kwak, {Hee Jae} and Hyunjin Jeong and Ko, {Hyun Jeong} and Kim, {Seung Hyun}",

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year = "2023",

doi = "10.1080/10286020.2022.2163633",

language = "English",

journal = "Journal of Asian Natural Products Research",

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T1 - Chemical constituents from the stem bark of Albizia julibrissin and their SREBP-1c inhibitory activity

AU - Xian, Meiling

AU - Oh, Mira

AU - Kwak, Hee Jae

AU - Jeong, Hyunjin

AU - Ko, Hyun Jeong

AU - Kim, Seung Hyun

PY - 2023

Y1 - 2023

N2 - One new lignan, julibrissinoside II, along with thirteen known compounds, was isolated from the stem bark of Albizia julibrissin. The structure of julibrissinoside II was determined on the basis of extensive spectroscopic methods, including NMR and CD spectroscopic data. The isolated compounds were tested for their SREBP-1c inhibitory activity at different concentrations using mouse hepatocyte AML12 cell lines. Among them, linoleic acid (2) and 3-O-methylfisetin (4) showed significant SREBP-1c inhibitory activity at the concentration of 100 µM.

AB - One new lignan, julibrissinoside II, along with thirteen known compounds, was isolated from the stem bark of Albizia julibrissin. The structure of julibrissinoside II was determined on the basis of extensive spectroscopic methods, including NMR and CD spectroscopic data. The isolated compounds were tested for their SREBP-1c inhibitory activity at different concentrations using mouse hepatocyte AML12 cell lines. Among them, linoleic acid (2) and 3-O-methylfisetin (4) showed significant SREBP-1c inhibitory activity at the concentration of 100 µM.

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SN - 1028-6020

JO - Journal of Asian Natural Products Research

JF - Journal of Asian Natural Products Research

ER -

Chemical constituents from the stem bark of Albizia julibrissin and their SREBP-1c inhibitory activity

Abstract

Bibliographical note

All Science Journal Classification (ASJC) codes

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