Chemical constituents isolated from Paeonia lactiflora roots and their neuroprotective activity against oxidative stress in vitro

Seung Hyun Kim, Mi Kyeong Lee, Ki Yong Lee, Sang Hyun Sung, Jinwoong Kim, Young Choong Kim

Research output: Contribution to journalArticle

41 Citations (Scopus)

Abstract

The methanolic extract of Paeonia lactiflora roots significantly protected primary cultures of rat cortical cells exposed to oxidative stress induced by H2O2. Seven monoterpenes, paeonilactone-B (1), paeonilactone-C (2), paeoniflorigenone (3), benzoylpaeoniflorin (4), paeoniflorin (5), oxypaeoniflorin (6) and albiflorin (7), were isolated by bioactivity-guided fractionation and further separation using chromatographic techniques. Among them, compounds 2 and 4 significantly protected primary cultures of rat cortical cells against H2O2-induced neurotoxicity.

Original languageEnglish
Pages (from-to)1138-1140
Number of pages3
JournalJournal of Enzyme Inhibition and Medicinal Chemistry
Volume24
Issue number5
DOIs
Publication statusPublished - 2009 Oct 1

Fingerprint

Paeonia
Oxidative Stress
Monoterpenes
In Vitro Techniques
paeonilactone B
albiflorin
peoniflorin
oxypaeoniflora
benzoylpaeoniflorin
paeoniflorigenone

All Science Journal Classification (ASJC) codes

  • Pharmacology
  • Drug Discovery

Cite this

Kim, Seung Hyun ; Lee, Mi Kyeong ; Lee, Ki Yong ; Sung, Sang Hyun ; Kim, Jinwoong ; Kim, Young Choong. / Chemical constituents isolated from Paeonia lactiflora roots and their neuroprotective activity against oxidative stress in vitro. In: Journal of Enzyme Inhibition and Medicinal Chemistry. 2009 ; Vol. 24, No. 5. pp. 1138-1140.
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Chemical constituents isolated from Paeonia lactiflora roots and their neuroprotective activity against oxidative stress in vitro. / Kim, Seung Hyun; Lee, Mi Kyeong; Lee, Ki Yong; Sung, Sang Hyun; Kim, Jinwoong; Kim, Young Choong.

In: Journal of Enzyme Inhibition and Medicinal Chemistry, Vol. 24, No. 5, 01.10.2009, p. 1138-1140.

Research output: Contribution to journalArticle

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AU - Kim, Seung Hyun

AU - Lee, Mi Kyeong

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AU - Sung, Sang Hyun

AU - Kim, Jinwoong

AU - Kim, Young Choong

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AB - The methanolic extract of Paeonia lactiflora roots significantly protected primary cultures of rat cortical cells exposed to oxidative stress induced by H2O2. Seven monoterpenes, paeonilactone-B (1), paeonilactone-C (2), paeoniflorigenone (3), benzoylpaeoniflorin (4), paeoniflorin (5), oxypaeoniflorin (6) and albiflorin (7), were isolated by bioactivity-guided fractionation and further separation using chromatographic techniques. Among them, compounds 2 and 4 significantly protected primary cultures of rat cortical cells against H2O2-induced neurotoxicity.

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