Chemical constituents isolated from Polygala japonica leaves and their inhibitory effect on nitric oxide production in vitro

Seung Hyun Kim; Sin Duk Jang; Ki Yong Lee; Sang Hyun Sung; Young Choong Kim

doi:10.1080/14756360802051362

Chemical constituents isolated from Polygala japonica leaves and their inhibitory effect on nitric oxide production in vitro

Seung Hyun Kim, Sin Duk Jang, Ki Yong Lee, Sang Hyun Sung, Young Choong Kim

Department of Pharmacy

Research output: Contribution to journal › Article › peer-review

18 Citations (Scopus)

Abstract

A methanolic extract of dried leaves of Polygala japonica Houtt (Polygalaceae) significantly attenuated nitric oxide production in lipopolysaccharide-simulated BV2 microglia. Five anthraquinones chrysophanol (1), emodin (2), aloe-emodin (3), emodin 8-O-β-D-glucopyranoside (4) and trihydroxy anthraquinone (5), and four flavonoids kaempferol (6), chrysoeriol (7), kaempferol 3-gentiobioside (8) and isorhamnetin (9) were isolated from the methanolic extract using bioactivity-guided fractionation. Among them, compounds 1-4, 6 and 7 showed significant inhibitory effect on lipopolysaccharide-induced nitric oxide production in BV2 microglia at the concentrations ranging from 1.0 to 100.0 μM.

Original language	English
Pages (from-to)	230-233
Number of pages	4
Journal	Journal of Enzyme Inhibition and Medicinal Chemistry
Volume	24
Issue number	1
DOIs	https://doi.org/10.1080/14756360802051362
Publication status	Published - 2009

Bibliographical note

Funding Information:
This research was supported by a grant PF06200-00 from Plant Diversity Research Center of the 21st Century Frontier Research Program funded by the Ministry of Science and Technology, Korea.

All Science Journal Classification (ASJC) codes

Pharmacology
Drug Discovery

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title = "Chemical constituents isolated from Polygala japonica leaves and their inhibitory effect on nitric oxide production in vitro",

abstract = "A methanolic extract of dried leaves of Polygala japonica Houtt (Polygalaceae) significantly attenuated nitric oxide production in lipopolysaccharide-simulated BV2 microglia. Five anthraquinones chrysophanol (1), emodin (2), aloe-emodin (3), emodin 8-O-β-D-glucopyranoside (4) and trihydroxy anthraquinone (5), and four flavonoids kaempferol (6), chrysoeriol (7), kaempferol 3-gentiobioside (8) and isorhamnetin (9) were isolated from the methanolic extract using bioactivity-guided fractionation. Among them, compounds 1-4, 6 and 7 showed significant inhibitory effect on lipopolysaccharide-induced nitric oxide production in BV2 microglia at the concentrations ranging from 1.0 to 100.0 μM.",

author = "Kim, {Seung Hyun} and Jang, {Sin Duk} and Lee, {Ki Yong} and Sung, {Sang Hyun} and Kim, {Young Choong}",

note = "Funding Information: This research was supported by a grant PF06200-00 from Plant Diversity Research Center of the 21st Century Frontier Research Program funded by the Ministry of Science and Technology, Korea.",

year = "2009",

doi = "10.1080/14756360802051362",

language = "English",

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AU - Kim, Seung Hyun

AU - Jang, Sin Duk

AU - Lee, Ki Yong

AU - Sung, Sang Hyun

AU - Kim, Young Choong

N1 - Funding Information: This research was supported by a grant PF06200-00 from Plant Diversity Research Center of the 21st Century Frontier Research Program funded by the Ministry of Science and Technology, Korea.

PY - 2009

Y1 - 2009

N2 - A methanolic extract of dried leaves of Polygala japonica Houtt (Polygalaceae) significantly attenuated nitric oxide production in lipopolysaccharide-simulated BV2 microglia. Five anthraquinones chrysophanol (1), emodin (2), aloe-emodin (3), emodin 8-O-β-D-glucopyranoside (4) and trihydroxy anthraquinone (5), and four flavonoids kaempferol (6), chrysoeriol (7), kaempferol 3-gentiobioside (8) and isorhamnetin (9) were isolated from the methanolic extract using bioactivity-guided fractionation. Among them, compounds 1-4, 6 and 7 showed significant inhibitory effect on lipopolysaccharide-induced nitric oxide production in BV2 microglia at the concentrations ranging from 1.0 to 100.0 μM.

AB - A methanolic extract of dried leaves of Polygala japonica Houtt (Polygalaceae) significantly attenuated nitric oxide production in lipopolysaccharide-simulated BV2 microglia. Five anthraquinones chrysophanol (1), emodin (2), aloe-emodin (3), emodin 8-O-β-D-glucopyranoside (4) and trihydroxy anthraquinone (5), and four flavonoids kaempferol (6), chrysoeriol (7), kaempferol 3-gentiobioside (8) and isorhamnetin (9) were isolated from the methanolic extract using bioactivity-guided fractionation. Among them, compounds 1-4, 6 and 7 showed significant inhibitory effect on lipopolysaccharide-induced nitric oxide production in BV2 microglia at the concentrations ranging from 1.0 to 100.0 μM.

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Chemical constituents isolated from Polygala japonica leaves and their inhibitory effect on nitric oxide production in vitro

Abstract

Bibliographical note

All Science Journal Classification (ASJC) codes

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