Chemical constituents of alnus firma and their inhibitory activity on lipopolysaccharide-induced nitric oxide production in BV2 microglia

Min A. Lee, Hee Kyoung Lee, Seung Hyun Kim, Young Choong Kim, Sang Hyun Sung

Research output: Contribution to journalArticle

22 Citations (Scopus)

Abstract

A methanolic extract of Alnus firma barks (Betulaceae) significantly attenuated nitric oxide production in lipopolysaccharide-stimulated BV2 microglia. Two new compounds, characterized as 4-hydroxy-2,6-dimethoxyphenyl 6-O-syringoyl-β-D-glucopyranoside (1) and 4-hydroxy-2,6-dimethoxyphenyl 6-O-vanilloyl-β-D-glucopyranoside (2), were isolated from the barks of A. firma using bioactivity-guided fractionation, together with two known phenolic glycosides (3, 4) and 11 known diarylheptanoids (515). Among these compounds, 14 and 611 showed significant inhibitory effect on lipopolysaccharide-induced nitric oxide production in BV2 microglial cells at concentrations ranging from 10μ M to 100μ M.

Original languageEnglish
Pages (from-to)1007-1010
Number of pages4
JournalPlanta Medica
Volume76
Issue number10
DOIs
Publication statusPublished - 2010 Jul 29

Fingerprint

Alnus
Microglia
Lipopolysaccharides
Nitric Oxide
Diarylheptanoids
Betulaceae
Fractionation
Glycosides
Bioactivity

All Science Journal Classification (ASJC) codes

  • Analytical Chemistry
  • Molecular Medicine
  • Pharmacology
  • Pharmaceutical Science
  • Drug Discovery
  • Complementary and alternative medicine
  • Organic Chemistry

Cite this

Lee, Min A. ; Lee, Hee Kyoung ; Kim, Seung Hyun ; Kim, Young Choong ; Sung, Sang Hyun. / Chemical constituents of alnus firma and their inhibitory activity on lipopolysaccharide-induced nitric oxide production in BV2 microglia. In: Planta Medica. 2010 ; Vol. 76, No. 10. pp. 1007-1010.
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Chemical constituents of alnus firma and their inhibitory activity on lipopolysaccharide-induced nitric oxide production in BV2 microglia. / Lee, Min A.; Lee, Hee Kyoung; Kim, Seung Hyun; Kim, Young Choong; Sung, Sang Hyun.

In: Planta Medica, Vol. 76, No. 10, 29.07.2010, p. 1007-1010.

Research output: Contribution to journalArticle

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