Persea americana Mill., Lauraceae, commonly known as the avocado, is native to tropical and subtropical regions, including Brazil. From the leaves of P. americana, one previously undescribed flavonol glycoside (1) together with ten known flavonoids (2–11), four megastigmane glycosides (12–15) and two lignans (16–17) were isolated. Their structures were determined by extensive spectroscopic methods including 1D- and 2D-nuclear magnetic resonance and mass spectrometry data. This is the first investigation that reports megastigmane glycoside and lignan classes within the genus Persea. All the isolated compounds have been assessed through the cell survival of larval zebrafish following neomycin-induced damage and the cell viability of a House Ear Institute-Organ of Corti 1 mouse auditory cell line. Among the tested compounds, juglanin (2) and (+)-lyoniresinol (16) showed significant cell regeneration in neomycin-damaged hair cell without cellular toxicity.
Bibliographical noteFunding Information:
This work was supported by the Technology Innovation Program ( 10080691 , Development of an individual approval health functional food and global product; protection of hearing loss and improvement of auditory function for the people with light to moderate hearing loss (26–55 dB of pure tone audiometry threshold using avocado fraction) funded by the Ministry of Trade, Industry & Energy ( MOTIE , Korea).
All Science Journal Classification (ASJC) codes
- Pharmacology, Toxicology and Pharmaceutics(all)