Chemical constituents of leaves of Persea americana (avocado) and their protective effects against neomycin-induced hair cell damage

Seon Ju Park, Youn Hee Nam, Isabel Rodriguez, Jun Hyung Park, Hee Jae Kwak, Youngse Oh, Mira Oh, Min Seon Park, Kye Wan Lee, Jung Suk Lee, Do Hoon Kim, Yu Hwa Park, In Seok Moon, Se Young Choung, Kwang Won Jeong, Bin Na Hong, Tong Ho Kang, Seung Hyun Kim

Research output: Contribution to journalArticlepeer-review

11 Citations (Scopus)


Persea americana Mill., Lauraceae, commonly known as the avocado, is native to tropical and subtropical regions, including Brazil. From the leaves of P. americana, one previously undescribed flavonol glycoside (1) together with ten known flavonoids (2–11), four megastigmane glycosides (12–15) and two lignans (16–17) were isolated. Their structures were determined by extensive spectroscopic methods including 1D- and 2D-nuclear magnetic resonance and mass spectrometry data. This is the first investigation that reports megastigmane glycoside and lignan classes within the genus Persea. All the isolated compounds have been assessed through the cell survival of larval zebrafish following neomycin-induced damage and the cell viability of a House Ear Institute-Organ of Corti 1 mouse auditory cell line. Among the tested compounds, juglanin (2) and (+)-lyoniresinol (16) showed significant cell regeneration in neomycin-damaged hair cell without cellular toxicity.

Original languageEnglish
Pages (from-to)739-743
Number of pages5
JournalRevista Brasileira de Farmacognosia
Issue number6
Publication statusPublished - 2019 Nov 1

Bibliographical note

Funding Information:
This work was supported by the Technology Innovation Program ( 10080691 , Development of an individual approval health functional food and global product; protection of hearing loss and improvement of auditory function for the people with light to moderate hearing loss (26–55 dB of pure tone audiometry threshold using avocado fraction) funded by the Ministry of Trade, Industry & Energy ( MOTIE , Korea).

Publisher Copyright:
© 2019

All Science Journal Classification (ASJC) codes

  • Pharmacology, Toxicology and Pharmaceutics(all)


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