Chemical Constituents of Phoebe poilanei and Their Cytotoxic Activity

Nguyen Thi Viet Thanh, Tran Thi Minh, Dinh Thi Thu Hien, Ho Duc Cuong, Yohan Seo, Seon Ju Park, Wan Namkung, Nguyen Xuan Nhiem, Pham Hai Yen, Seung Hyun Kim, Phan Van Kiem

Research output: Contribution to journalArticlepeer-review

Abstract

Two new flavonol glycosides, rhamnocitrin 3-O-α-L-rhamnopyranosyl-(1→6)-[α-L-rhamnopyranosyl-(1→2)]-β-D-glucopyranoside (1) and quercetin 3-O-6-Z-p-coumaroyl-β-D-glucopyranosyl-(1→2)-α-L-rhamnopyranoside (2), along with 3 flavonol glycosides, isoquercitrin (3), rutin (4), and quercetin 3-O-α-L-rhamnopyranosyl-(1→6)-β-D-galactopyranoside (5), and two known sesquiterpenes, alismol (6) and spathulenol (7), were isolated from the leaves of Phoebe poilanei Kosterm. Their chemical structures were elucidated by analyses of their high-resolution electrospray ionization mass spectral data and nuclear magnetic resonance spectral data and comparison with those reported in the literature. Two sesquiterpenes 6 and 7 were found to exhibit moderate cytotoxic activity with IC50 values ranging from 21.6 to 29.8 µM.

Original languageEnglish
JournalNatural product communications
Volume14
Issue number5
DOIs
Publication statusPublished - 2019

All Science Journal Classification (ASJC) codes

  • Pharmacology
  • Plant Science
  • Drug Discovery
  • Complementary and alternative medicine

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