Chemical constituents of Trichosanthes kirilowii and their cytotoxic activities

Chau Van Minh, Nguyen Xuan Nhiem, Hoang Thi Yen, Phan Van Kiem, Bui Huu Tai, Hoang Le Tuan Anh, Truong Thi Thu Hien, Seon Ju Park, Nanyoung Kim, Seung Hyun Kim

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Abstract

Abstract One new lignan, trichobenzolignan (1), and seven known compounds, ligballinol (2), (-)-pinoresinol (3), ehletianol C (4), luteolin 7-O-β-D-glucopyranoside (5), chrysoeriol-7- O-β-D-glucopyranoside (6), 10α-cucurbita-5,24-dien-3β-ol (7), and arvenin I (8). Their structures were established on the basis of spectral and chemical evidence, which were in agreement with those reported in literature. The cytotoxic activities of these compounds were evaluated on four cancer cell lines such as A-549 (human lung cancer), HT-29 (human colon adenocarcinoma), OVCAR (human ovarian carcinoma), and MCF-7 (human breast cancer). As the results, compound 7 showed significant activity on HT-29 and OVCAR cancer cell lines with IC50 of 4.1 and 6.5 μM, respectively. Compounds 1, 5, 6, and 8 exhibited moderate activities in all cancer cell lines with IC50 ranging from 11.3 to 42.8 μM.

Original languageEnglish
Article number490
Pages (from-to)1443-1448
Number of pages6
JournalArchives of pharmacal research
Volume38
Issue number8
DOIs
Publication statusPublished - 2015 Aug 8

All Science Journal Classification (ASJC) codes

  • Molecular Medicine
  • Drug Discovery
  • Organic Chemistry

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    Minh, C. V., Nhiem, N. X., Yen, H. T., Kiem, P. V., Tai, B. H., Le Tuan Anh, H., Hien, T. T. T., Park, S. J., Kim, N., & Kim, S. H. (2015). Chemical constituents of Trichosanthes kirilowii and their cytotoxic activities. Archives of pharmacal research, 38(8), 1443-1448. [490]. https://doi.org/10.1007/s12272-014-0490-6