Chemical constituents of Trichosanthes kirilowii and their cytotoxic activities

Chau Van Minh, Nguyen Xuan Nhiem, Hoang Thi Yen, Phan Van Kiem, Bui Huu Tai, Hoang Le Tuan Anh, Truong Thi Thu Hien, Seon Ju Park, Nanyoung Kim, Seung Hyun Kim

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

Abstract One new lignan, trichobenzolignan (1), and seven known compounds, ligballinol (2), (-)-pinoresinol (3), ehletianol C (4), luteolin 7-O-β-D-glucopyranoside (5), chrysoeriol-7- O-β-D-glucopyranoside (6), 10α-cucurbita-5,24-dien-3β-ol (7), and arvenin I (8). Their structures were established on the basis of spectral and chemical evidence, which were in agreement with those reported in literature. The cytotoxic activities of these compounds were evaluated on four cancer cell lines such as A-549 (human lung cancer), HT-29 (human colon adenocarcinoma), OVCAR (human ovarian carcinoma), and MCF-7 (human breast cancer). As the results, compound 7 showed significant activity on HT-29 and OVCAR cancer cell lines with IC50 of 4.1 and 6.5 μM, respectively. Compounds 1, 5, 6, and 8 exhibited moderate activities in all cancer cell lines with IC50 ranging from 11.3 to 42.8 μM.

Original languageEnglish
Article number490
Pages (from-to)1443-1448
Number of pages6
JournalArchives of Pharmacal Research
Volume38
Issue number8
DOIs
Publication statusPublished - 2015 Aug 8

Fingerprint

Trichosanthes
Cells
Luteolin
Lignans
Cell Line
Inhibitory Concentration 50
Carcinoma
Ovarian Neoplasms
Lung Neoplasms
Neoplasms
Colon
Adenocarcinoma
Breast Neoplasms

All Science Journal Classification (ASJC) codes

  • Molecular Medicine
  • Drug Discovery
  • Organic Chemistry

Cite this

Minh, C. V., Nhiem, N. X., Yen, H. T., Kiem, P. V., Tai, B. H., Le Tuan Anh, H., ... Kim, S. H. (2015). Chemical constituents of Trichosanthes kirilowii and their cytotoxic activities. Archives of Pharmacal Research, 38(8), 1443-1448. [490]. https://doi.org/10.1007/s12272-014-0490-6
Minh, Chau Van ; Nhiem, Nguyen Xuan ; Yen, Hoang Thi ; Kiem, Phan Van ; Tai, Bui Huu ; Le Tuan Anh, Hoang ; Hien, Truong Thi Thu ; Park, Seon Ju ; Kim, Nanyoung ; Kim, Seung Hyun. / Chemical constituents of Trichosanthes kirilowii and their cytotoxic activities. In: Archives of Pharmacal Research. 2015 ; Vol. 38, No. 8. pp. 1443-1448.
@article{761943e72f19418caf7676864b140c1d,
title = "Chemical constituents of Trichosanthes kirilowii and their cytotoxic activities",
abstract = "Abstract One new lignan, trichobenzolignan (1), and seven known compounds, ligballinol (2), (-)-pinoresinol (3), ehletianol C (4), luteolin 7-O-β-D-glucopyranoside (5), chrysoeriol-7- O-β-D-glucopyranoside (6), 10α-cucurbita-5,24-dien-3β-ol (7), and arvenin I (8). Their structures were established on the basis of spectral and chemical evidence, which were in agreement with those reported in literature. The cytotoxic activities of these compounds were evaluated on four cancer cell lines such as A-549 (human lung cancer), HT-29 (human colon adenocarcinoma), OVCAR (human ovarian carcinoma), and MCF-7 (human breast cancer). As the results, compound 7 showed significant activity on HT-29 and OVCAR cancer cell lines with IC50 of 4.1 and 6.5 μM, respectively. Compounds 1, 5, 6, and 8 exhibited moderate activities in all cancer cell lines with IC50 ranging from 11.3 to 42.8 μM.",
author = "Minh, {Chau Van} and Nhiem, {Nguyen Xuan} and Yen, {Hoang Thi} and Kiem, {Phan Van} and Tai, {Bui Huu} and {Le Tuan Anh}, Hoang and Hien, {Truong Thi Thu} and Park, {Seon Ju} and Nanyoung Kim and Kim, {Seung Hyun}",
year = "2015",
month = "8",
day = "8",
doi = "10.1007/s12272-014-0490-6",
language = "English",
volume = "38",
pages = "1443--1448",
journal = "Archives of Pharmacal Research",
issn = "0253-6269",
publisher = "Pharmaceutical Society of Korea",
number = "8",

}

Minh, CV, Nhiem, NX, Yen, HT, Kiem, PV, Tai, BH, Le Tuan Anh, H, Hien, TTT, Park, SJ, Kim, N & Kim, SH 2015, 'Chemical constituents of Trichosanthes kirilowii and their cytotoxic activities', Archives of Pharmacal Research, vol. 38, no. 8, 490, pp. 1443-1448. https://doi.org/10.1007/s12272-014-0490-6

Chemical constituents of Trichosanthes kirilowii and their cytotoxic activities. / Minh, Chau Van; Nhiem, Nguyen Xuan; Yen, Hoang Thi; Kiem, Phan Van; Tai, Bui Huu; Le Tuan Anh, Hoang; Hien, Truong Thi Thu; Park, Seon Ju; Kim, Nanyoung; Kim, Seung Hyun.

In: Archives of Pharmacal Research, Vol. 38, No. 8, 490, 08.08.2015, p. 1443-1448.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Chemical constituents of Trichosanthes kirilowii and their cytotoxic activities

AU - Minh, Chau Van

AU - Nhiem, Nguyen Xuan

AU - Yen, Hoang Thi

AU - Kiem, Phan Van

AU - Tai, Bui Huu

AU - Le Tuan Anh, Hoang

AU - Hien, Truong Thi Thu

AU - Park, Seon Ju

AU - Kim, Nanyoung

AU - Kim, Seung Hyun

PY - 2015/8/8

Y1 - 2015/8/8

N2 - Abstract One new lignan, trichobenzolignan (1), and seven known compounds, ligballinol (2), (-)-pinoresinol (3), ehletianol C (4), luteolin 7-O-β-D-glucopyranoside (5), chrysoeriol-7- O-β-D-glucopyranoside (6), 10α-cucurbita-5,24-dien-3β-ol (7), and arvenin I (8). Their structures were established on the basis of spectral and chemical evidence, which were in agreement with those reported in literature. The cytotoxic activities of these compounds were evaluated on four cancer cell lines such as A-549 (human lung cancer), HT-29 (human colon adenocarcinoma), OVCAR (human ovarian carcinoma), and MCF-7 (human breast cancer). As the results, compound 7 showed significant activity on HT-29 and OVCAR cancer cell lines with IC50 of 4.1 and 6.5 μM, respectively. Compounds 1, 5, 6, and 8 exhibited moderate activities in all cancer cell lines with IC50 ranging from 11.3 to 42.8 μM.

AB - Abstract One new lignan, trichobenzolignan (1), and seven known compounds, ligballinol (2), (-)-pinoresinol (3), ehletianol C (4), luteolin 7-O-β-D-glucopyranoside (5), chrysoeriol-7- O-β-D-glucopyranoside (6), 10α-cucurbita-5,24-dien-3β-ol (7), and arvenin I (8). Their structures were established on the basis of spectral and chemical evidence, which were in agreement with those reported in literature. The cytotoxic activities of these compounds were evaluated on four cancer cell lines such as A-549 (human lung cancer), HT-29 (human colon adenocarcinoma), OVCAR (human ovarian carcinoma), and MCF-7 (human breast cancer). As the results, compound 7 showed significant activity on HT-29 and OVCAR cancer cell lines with IC50 of 4.1 and 6.5 μM, respectively. Compounds 1, 5, 6, and 8 exhibited moderate activities in all cancer cell lines with IC50 ranging from 11.3 to 42.8 μM.

UR - http://www.scopus.com/inward/record.url?scp=84938748992&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84938748992&partnerID=8YFLogxK

U2 - 10.1007/s12272-014-0490-6

DO - 10.1007/s12272-014-0490-6

M3 - Article

VL - 38

SP - 1443

EP - 1448

JO - Archives of Pharmacal Research

JF - Archives of Pharmacal Research

SN - 0253-6269

IS - 8

M1 - 490

ER -

Minh CV, Nhiem NX, Yen HT, Kiem PV, Tai BH, Le Tuan Anh H et al. Chemical constituents of Trichosanthes kirilowii and their cytotoxic activities. Archives of Pharmacal Research. 2015 Aug 8;38(8):1443-1448. 490. https://doi.org/10.1007/s12272-014-0490-6