Chemical genetics for therapeutic target mining

Joong Sup Shim, Ho Jeong Kwon

Research output: Contribution to journalReview article

19 Citations (Scopus)

Abstract

Chemical genetics is an emerging research field that utilises biologically active small molecules to study biological functions of genes and their products. The direct regulation of the protein function by the biologically active small molecules can alternate the gene mutagenesis studies utilised in conventional genetics. Like conventional genetics, chemical genetics can be divided into two concepts - 'forward' and 'reverse' chemical genetics. These approaches of chemical genetics have a tremendous impact on both functional genomics and drug development. This review focuses on the two ways in which chemical genetics can be used for therapeutic target mining and their practical application in drug development, particularly, in angiogenesis-related diseases.

Original languageEnglish
Pages (from-to)653-661
Number of pages9
JournalExpert Opinion on Therapeutic Targets
Volume8
Issue number6
DOIs
Publication statusPublished - 2004 Dec 1

Fingerprint

Therapeutics
Genes
Reverse Genetics
Mutagenesis
Molecules
Genomics
Pharmaceutical Preparations
Genetics
Research
Proteins

All Science Journal Classification (ASJC) codes

  • Molecular Medicine
  • Pharmacology
  • Drug Discovery
  • Clinical Biochemistry

Cite this

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Chemical genetics for therapeutic target mining. / Shim, Joong Sup; Kwon, Ho Jeong.

In: Expert Opinion on Therapeutic Targets, Vol. 8, No. 6, 01.12.2004, p. 653-661.

Research output: Contribution to journalReview article

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