Chemical genomics-based target identification and validation of anti-angiogenic agents

Research output: Contribution to journalReview article

12 Citations (Scopus)

Abstract

The recent use of chemical genomics to identify bioactive small molecules that interact with specific proteins has had a tremendous impact on both the functional analysis of genes and drug development. Accordingly, the current review focuses on the utilization of this new research engine in the target identification and validation of anti-angiogenic agents capable of regulating the growth and spread of cancer cells. In addition, the use of chemical genomics to discover novel anti-angiogenic agent targets and to validate their biological relevancy is providing new insights into the biological role of targets in angiogenesis as well as advancing the development of new anti-angiogenic agents.

Original languageEnglish
Pages (from-to)717-726
Number of pages10
JournalCurrent Medicinal Chemistry
Volume10
Issue number9
DOIs
Publication statusPublished - 2003

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Molecular Medicine
  • Pharmacology
  • Drug Discovery
  • Organic Chemistry

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