Chemical, Structural Properties, and Osteoconductive Effectiveness of Bone Block Derived from Porcine Cancellous Bone

Su Hyang Kim, Jung Wook Shin, Su A. Park, Young Kon Kim, Mun Soo Park, James M. Mok, Woo Ick Yang, jinwoo lee

Research output: Contribution to journalArticle

34 Citations (Scopus)

Abstract

The purpose of this study is to determine the efficacy of bioactive calcium phosphate obtained from porcine cancellous bone for the treatment of bone defects and nonunion. Porcine cancellous bone blocks were heat treated at 1300 °C for 2 h. The chemical composition, calcium-to-phosphate ratio, and microstructure of the porcine bone blocks were examined. For in vivo implantation, bone defects were created on the anteromedial aspect of the proximal tibia in seven beagle dogs and the xenograft bone blocks were placed into these defects. Plain radiographs were taken at 2-week intervals for roentgenographic evaluation. At 12 weeks, the specimens were stained with hematoxylin and eosin (H&E). The composition and morphology of heat-treated porcine cancellous bone were found to be similar to heat-treated human cancellous bone. Radiographs showed union between the host bone/bone-block interfaces. At 12 weeks, uniform and substantial new bone formation was observed. It is concluded that heat-treated porcine cancellous bone demonstrated effective osteoconductivity. This high-temperature heat-treatment technique has several advantages, including decreased risk of disease transmission and immunoreactivity, while also offering excellent biocompatibility.

Original languageEnglish
Pages (from-to)69-74
Number of pages6
JournalJournal of Biomedical Materials Research - Part B Applied Biomaterials
Volume68
Issue number1
DOIs
Publication statusPublished - 2004 Jan 15

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Structural properties
Bone
Defects
Calcium phosphate
Hematoxylin
Eosine Yellowish-(YS)
Chemical analysis
Biocompatibility
Heterografts
Calcium
Phosphates
Heat treatment
Microstructure
Hot Temperature

All Science Journal Classification (ASJC) codes

  • Biomaterials
  • Biomedical Engineering

Cite this

Kim, Su Hyang ; Shin, Jung Wook ; Park, Su A. ; Kim, Young Kon ; Park, Mun Soo ; Mok, James M. ; Yang, Woo Ick ; lee, jinwoo. / Chemical, Structural Properties, and Osteoconductive Effectiveness of Bone Block Derived from Porcine Cancellous Bone. In: Journal of Biomedical Materials Research - Part B Applied Biomaterials. 2004 ; Vol. 68, No. 1. pp. 69-74.
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Chemical, Structural Properties, and Osteoconductive Effectiveness of Bone Block Derived from Porcine Cancellous Bone. / Kim, Su Hyang; Shin, Jung Wook; Park, Su A.; Kim, Young Kon; Park, Mun Soo; Mok, James M.; Yang, Woo Ick; lee, jinwoo.

In: Journal of Biomedical Materials Research - Part B Applied Biomaterials, Vol. 68, No. 1, 15.01.2004, p. 69-74.

Research output: Contribution to journalArticle

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