Chemical structure and surface modification of dendritic nanomaterials tailored for therapeutic and diagnostic applications

Ja Hye Myung, Hao Jui Hsu, Jason Bugno, Kevin A. Tam, Seungpyo Hong

Research output: Contribution to journalReview articlepeer-review

8 Citations (Scopus)


Dendritic nanomaterials have attracted a great deal of scientific interest due to their high capacity for multifunctionalization and potential in various biomedical applications, such as drug/gene delivery and diagnostic systems. Depending on the molecular structure and starting monomers, several different types of dendrimers have been developed, including poly(amidoamine) (PAMAM), poly(propylenimine) (PPI), and poly(L-lysine) (PLL) dendrimers, in addition to modified dendritic nanomaterials, such as Janus dendrimers and dendritic block copolymers. The chemical structure and surface modification of dendritic nanomaterials have been found to play a critical role in governing their biological behaviors. In this review, we present a comprehensive overview focusing on the synthesis and chemical structures of dendrimers and modified dendritic nanomaterials that are currently being investigated for drug delivery, gene delivery, and diagnostic applications. In addition, the impact of chemical surface modification and functionalization to the dendritic nanomaterials on their therapeutic and diagnostic applications are highlighted.

Original languageEnglish
Pages (from-to)1542-1554
Number of pages13
JournalCurrent Topics in Medicinal Chemistry
Issue number13
Publication statusPublished - 2017

Bibliographical note

Funding Information:
This work was supported by National Science Foundation (NSF) under grant # DMR-1409161 and National Cancer Institute (NCI), National Institutes of Health (NIH) under grant no. R01-CA182528.

Publisher Copyright:
© 2017 Bentham Science Publishers.

All Science Journal Classification (ASJC) codes

  • Drug Discovery


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