Chemically induced rat mammary tumor treated with tamoxifen showed decreased expression of cyclin D1, cyclin E, and p21Cip1

Tae Jung Jang, Jae Hum Park, Meeyon Cho, Jung Ran Kim

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

We studied the effects of tamoxifen (TAM) on the growth of 7,12-dimethylbenz(a)anthracene (DMBA)-induced rat mammary tumor and the expression of cyclin D1, cyclin E, p21Cip1, and estrogen receptors (ER) by performing immunohistochemistry and Western blot analysis. When tumor size reached between 10 and 15 mm in the largest dimension, the rats were divided into a DMBA-control group and a DMBA-TAM group. The administration of TAM markedly decreased the tumor development and showed decreased expression of bromodeoxyuridine, cyclin D1, cyclin E, and p21Cip1 when compared with those of the DMBA-control group; however, a few tumors showed progressive growth in spite of TAM treatment. These tumors had decreased expression of ER. This study suggests that TAM suppresses tumor development through the down-expression of cyclin D1 and cyclin E.

Original languageEnglish
Pages (from-to)109-116
Number of pages8
JournalCancer Letters
Volume170
Issue number2
DOIs
Publication statusPublished - 2001 Sep 20

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Cyclin E
Cyclin D1
Tamoxifen
9,10-Dimethyl-1,2-benzanthracene
Breast Neoplasms
Neoplasms
Estrogen Receptors
Control Groups
Bromodeoxyuridine
Growth
Western Blotting
Immunohistochemistry

All Science Journal Classification (ASJC) codes

  • Cancer Research
  • Molecular Biology
  • Oncology

Cite this

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abstract = "We studied the effects of tamoxifen (TAM) on the growth of 7,12-dimethylbenz(a)anthracene (DMBA)-induced rat mammary tumor and the expression of cyclin D1, cyclin E, p21Cip1, and estrogen receptors (ER) by performing immunohistochemistry and Western blot analysis. When tumor size reached between 10 and 15 mm in the largest dimension, the rats were divided into a DMBA-control group and a DMBA-TAM group. The administration of TAM markedly decreased the tumor development and showed decreased expression of bromodeoxyuridine, cyclin D1, cyclin E, and p21Cip1 when compared with those of the DMBA-control group; however, a few tumors showed progressive growth in spite of TAM treatment. These tumors had decreased expression of ER. This study suggests that TAM suppresses tumor development through the down-expression of cyclin D1 and cyclin E.",
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Chemically induced rat mammary tumor treated with tamoxifen showed decreased expression of cyclin D1, cyclin E, and p21Cip1 . / Jang, Tae Jung; Park, Jae Hum; Cho, Meeyon; Kim, Jung Ran.

In: Cancer Letters, Vol. 170, No. 2, 20.09.2001, p. 109-116.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Chemically induced rat mammary tumor treated with tamoxifen showed decreased expression of cyclin D1, cyclin E, and p21Cip1

AU - Jang, Tae Jung

AU - Park, Jae Hum

AU - Cho, Meeyon

AU - Kim, Jung Ran

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