Chemoselective ligation of maleimidosugars to peptides/protein for the preparation of neoglycopeptides/neoglycoprotein

Injae Shin, Hyuk Jun Jung, Myung Ryul Lee

Research output: Contribution to journalArticlepeer-review

44 Citations (Scopus)

Abstract

Two types of maleimidosugars as thiol-selective carbohydrates, 1-maleimidosugars and acetyl-linked maleimidosugars, were efficiently synthesized. They were coupled to glutathione, Fas peptide and bovine serium albumin (BSA) to prepare the corresponding glycosylated peptides and a protein via stable thioether linkages in a chemoselective manner.

Original languageEnglish
Pages (from-to)1325-1328
Number of pages4
JournalTetrahedron Letters
Volume42
Issue number7
DOIs
Publication statusPublished - 2001 Feb 12

Bibliographical note

Funding Information:
This work was supported by a grant from the Korea Research Foundation (1999-015-DP0218), Ministry of Education, Korea. I.S. thanks the Korea Basic Science Institute for synthesizing Fas peptide and providing us with mass spectra of glycosylated peptides and BSA.

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry

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