Chemoselective ligation of maleimidosugars to peptides/protein for the preparation of neoglycopeptides/neoglycoprotein

Injae Shin, Hyuk Jun Jung, Myung Ryul Lee

Research output: Contribution to journalArticle

42 Citations (Scopus)

Abstract

Two types of maleimidosugars as thiol-selective carbohydrates, 1-maleimidosugars and acetyl-linked maleimidosugars, were efficiently synthesized. They were coupled to glutathione, Fas peptide and bovine serium albumin (BSA) to prepare the corresponding glycosylated peptides and a protein via stable thioether linkages in a chemoselective manner.

Original languageEnglish
Pages (from-to)1325-1328
Number of pages4
JournalTetrahedron Letters
Volume42
Issue number7
DOIs
Publication statusPublished - 2001 Feb 12

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry

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