Two types of maleimidosugars as thiol-selective carbohydrates, 1-maleimidosugars and acetyl-linked maleimidosugars, were efficiently synthesized. They were coupled to glutathione, Fas peptide and bovine serium albumin (BSA) to prepare the corresponding glycosylated peptides and a protein via stable thioether linkages in a chemoselective manner.
Bibliographical noteFunding Information:
This work was supported by a grant from the Korea Research Foundation (1999-015-DP0218), Ministry of Education, Korea. I.S. thanks the Korea Basic Science Institute for synthesizing Fas peptide and providing us with mass spectra of glycosylated peptides and BSA.
All Science Journal Classification (ASJC) codes
- Drug Discovery
- Organic Chemistry