Chemoselective ligation of maleimidosugars to peptides/protein for the preparation of neoglycopeptides/neoglycoprotein

Injae Shin, Hyuk Jun Jung, Myung Ryul Lee

Research output: Contribution to journalArticle

41 Citations (Scopus)

Abstract

Two types of maleimidosugars as thiol-selective carbohydrates, 1-maleimidosugars and acetyl-linked maleimidosugars, were efficiently synthesized. They were coupled to glutathione, Fas peptide and bovine serium albumin (BSA) to prepare the corresponding glycosylated peptides and a protein via stable thioether linkages in a chemoselective manner.

Original languageEnglish
Pages (from-to)1325-1328
Number of pages4
JournalTetrahedron Letters
Volume42
Issue number7
DOIs
Publication statusPublished - 2001 Feb 12

Fingerprint

Ligation
Glycoproteins
Peptides
Sulfides
Sulfhydryl Compounds
Glutathione
Albumins
Proteins
Carbohydrates

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry

Cite this

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Chemoselective ligation of maleimidosugars to peptides/protein for the preparation of neoglycopeptides/neoglycoprotein. / Shin, Injae; Jung, Hyuk Jun; Lee, Myung Ryul.

In: Tetrahedron Letters, Vol. 42, No. 7, 12.02.2001, p. 1325-1328.

Research output: Contribution to journalArticle

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AU - Jung, Hyuk Jun

AU - Lee, Myung Ryul

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AB - Two types of maleimidosugars as thiol-selective carbohydrates, 1-maleimidosugars and acetyl-linked maleimidosugars, were efficiently synthesized. They were coupled to glutathione, Fas peptide and bovine serium albumin (BSA) to prepare the corresponding glycosylated peptides and a protein via stable thioether linkages in a chemoselective manner.

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