Chest and renal involvements, Birmingham vascular activity score more than 13.5 and five factor score (1996) more than 1 at diagnosis are significant predictors of relapse of microscopic polyangiitis

Yoon Jeong Oh, Sung Soo Ahn, Eun Seong Park, Seung Min Jung, Jason Jungsik Song, YongBeom Park, Sang Won Lee

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8 Citations (Scopus)

Abstract

Objective. We investigated whether specified organ involvements, antineutrophil cytoplasmic antibody (ANCA) positivity, Birmingham vasculitis activity score (BVAS) and five factor scores (FFS) at diagnosis could predict relapse of microscopic polyangiitis (MPA). Methods. We reviewed the medical records of 90 patients with MPA. We collected clinical and prognostic data, (MPO)-ANCA and proteinase 3 (PR3)- ANCA, BVAS and FFS at diagnosis, and we compared them between the two groups. The optimal cut-offvalues of BVAS and FFS (1996) for predicting relapse were extrapolated. Results. The mean age of patients (63 women) was 62.3 years and the mean follow-up duration was 41.7 months. At diagnosis, the mean BVAS, FFS (1996) and FFS (2009) of patients in no remission group were higher than those of patients in remission group (p < 0.005 for all). Patients in relapse group exhibited chest and renal manifestations more frequently than those in no relapse group and the mean BVAS and FFS (1996) of patients in relapse group were significantly higher than those of patients in remission group (p < 0.005 for all). There were no differences in MPO-ANCA and PR3-ANCA between the two groups. On multivariate logistic regression analysis, chest and renal manifestations were all independent predictors of relapse (OR 2.013 and OR 3.517). Patients with BVAS ≥13.5 and FFS ≥ 1 exhibited significantly increased risk of relapse than those not having (RR 4.408 and RR 3.030). Conclusion. Chest and renal involvements, BVAS ≥13.5 and FFS ≥1 at diagnosis were independent predictors of relapse of MPA.

Original languageEnglish
Pages (from-to)47-54
Number of pages8
JournalClinical and Experimental Rheumatology
Volume35
Publication statusPublished - 2017 Jan 1

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Microscopic Polyangiitis
Vasculitis
Blood Vessels
Thorax
Antineutrophil Cytoplasmic Antibodies
Kidney
Recurrence
Myeloblastin
Medical Records
Logistic Models
Regression Analysis

All Science Journal Classification (ASJC) codes

  • Rheumatology
  • Immunology and Allergy
  • Immunology

Cite this

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title = "Chest and renal involvements, Birmingham vascular activity score more than 13.5 and five factor score (1996) more than 1 at diagnosis are significant predictors of relapse of microscopic polyangiitis",
abstract = "Objective. We investigated whether specified organ involvements, antineutrophil cytoplasmic antibody (ANCA) positivity, Birmingham vasculitis activity score (BVAS) and five factor scores (FFS) at diagnosis could predict relapse of microscopic polyangiitis (MPA). Methods. We reviewed the medical records of 90 patients with MPA. We collected clinical and prognostic data, (MPO)-ANCA and proteinase 3 (PR3)- ANCA, BVAS and FFS at diagnosis, and we compared them between the two groups. The optimal cut-offvalues of BVAS and FFS (1996) for predicting relapse were extrapolated. Results. The mean age of patients (63 women) was 62.3 years and the mean follow-up duration was 41.7 months. At diagnosis, the mean BVAS, FFS (1996) and FFS (2009) of patients in no remission group were higher than those of patients in remission group (p < 0.005 for all). Patients in relapse group exhibited chest and renal manifestations more frequently than those in no relapse group and the mean BVAS and FFS (1996) of patients in relapse group were significantly higher than those of patients in remission group (p < 0.005 for all). There were no differences in MPO-ANCA and PR3-ANCA between the two groups. On multivariate logistic regression analysis, chest and renal manifestations were all independent predictors of relapse (OR 2.013 and OR 3.517). Patients with BVAS ≥13.5 and FFS ≥ 1 exhibited significantly increased risk of relapse than those not having (RR 4.408 and RR 3.030). Conclusion. Chest and renal involvements, BVAS ≥13.5 and FFS ≥1 at diagnosis were independent predictors of relapse of MPA.",
author = "Oh, {Yoon Jeong} and Ahn, {Sung Soo} and Park, {Eun Seong} and Jung, {Seung Min} and Song, {Jason Jungsik} and YongBeom Park and Lee, {Sang Won}",
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Chest and renal involvements, Birmingham vascular activity score more than 13.5 and five factor score (1996) more than 1 at diagnosis are significant predictors of relapse of microscopic polyangiitis. / Oh, Yoon Jeong; Ahn, Sung Soo; Park, Eun Seong; Jung, Seung Min; Song, Jason Jungsik; Park, YongBeom; Lee, Sang Won.

In: Clinical and Experimental Rheumatology, Vol. 35, 01.01.2017, p. 47-54.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Chest and renal involvements, Birmingham vascular activity score more than 13.5 and five factor score (1996) more than 1 at diagnosis are significant predictors of relapse of microscopic polyangiitis

AU - Oh, Yoon Jeong

AU - Ahn, Sung Soo

AU - Park, Eun Seong

AU - Jung, Seung Min

AU - Song, Jason Jungsik

AU - Park, YongBeom

AU - Lee, Sang Won

PY - 2017/1/1

Y1 - 2017/1/1

N2 - Objective. We investigated whether specified organ involvements, antineutrophil cytoplasmic antibody (ANCA) positivity, Birmingham vasculitis activity score (BVAS) and five factor scores (FFS) at diagnosis could predict relapse of microscopic polyangiitis (MPA). Methods. We reviewed the medical records of 90 patients with MPA. We collected clinical and prognostic data, (MPO)-ANCA and proteinase 3 (PR3)- ANCA, BVAS and FFS at diagnosis, and we compared them between the two groups. The optimal cut-offvalues of BVAS and FFS (1996) for predicting relapse were extrapolated. Results. The mean age of patients (63 women) was 62.3 years and the mean follow-up duration was 41.7 months. At diagnosis, the mean BVAS, FFS (1996) and FFS (2009) of patients in no remission group were higher than those of patients in remission group (p < 0.005 for all). Patients in relapse group exhibited chest and renal manifestations more frequently than those in no relapse group and the mean BVAS and FFS (1996) of patients in relapse group were significantly higher than those of patients in remission group (p < 0.005 for all). There were no differences in MPO-ANCA and PR3-ANCA between the two groups. On multivariate logistic regression analysis, chest and renal manifestations were all independent predictors of relapse (OR 2.013 and OR 3.517). Patients with BVAS ≥13.5 and FFS ≥ 1 exhibited significantly increased risk of relapse than those not having (RR 4.408 and RR 3.030). Conclusion. Chest and renal involvements, BVAS ≥13.5 and FFS ≥1 at diagnosis were independent predictors of relapse of MPA.

AB - Objective. We investigated whether specified organ involvements, antineutrophil cytoplasmic antibody (ANCA) positivity, Birmingham vasculitis activity score (BVAS) and five factor scores (FFS) at diagnosis could predict relapse of microscopic polyangiitis (MPA). Methods. We reviewed the medical records of 90 patients with MPA. We collected clinical and prognostic data, (MPO)-ANCA and proteinase 3 (PR3)- ANCA, BVAS and FFS at diagnosis, and we compared them between the two groups. The optimal cut-offvalues of BVAS and FFS (1996) for predicting relapse were extrapolated. Results. The mean age of patients (63 women) was 62.3 years and the mean follow-up duration was 41.7 months. At diagnosis, the mean BVAS, FFS (1996) and FFS (2009) of patients in no remission group were higher than those of patients in remission group (p < 0.005 for all). Patients in relapse group exhibited chest and renal manifestations more frequently than those in no relapse group and the mean BVAS and FFS (1996) of patients in relapse group were significantly higher than those of patients in remission group (p < 0.005 for all). There were no differences in MPO-ANCA and PR3-ANCA between the two groups. On multivariate logistic regression analysis, chest and renal manifestations were all independent predictors of relapse (OR 2.013 and OR 3.517). Patients with BVAS ≥13.5 and FFS ≥ 1 exhibited significantly increased risk of relapse than those not having (RR 4.408 and RR 3.030). Conclusion. Chest and renal involvements, BVAS ≥13.5 and FFS ≥1 at diagnosis were independent predictors of relapse of MPA.

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