Chinese liver fluke Clonorchis sinensis infection changes the gut microbiome and increases probiotic Lactobacillus in mice

Ju Yeong Kim, Eun Min Kim, Myung hee Yi, Jinyoung Lee, Seogwon Lee, Younjee Hwang, DongEun Yong, Woon Mok Sohn, Taisoon Yong

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Chinese liver fluke Clonorchis sinensis changes the host’s immune system. Recently, it has been reported that helminths including C. sinensis can ameliorate immune-related diseases such as allergy. In addition, recent studies showed that helminth infection can alleviate immune-mediated disorders by altering the gut microbiome. However, changes in the gut microbiome due to C. sinensis have not been reported yet. In this study, changes in the gut microbiome of C57BL/6 mice infected with C. sinensis metacercariae were evaluated over time. Stool was analyzed by 16S rRNA amplicon analysis using high-throughput sequencing technology. There was no apparent difference in species richness and diversity between the infected and control groups. However, the composition of the microbiome was different between the infected and control groups at 20 days and 30 days post-infection, and the difference disappeared at 50 days post-infection. In particular, this microbiome alteration was associated with a change in the relative abundance of genus Lactobacillus and the probiotic Lactobacillus species that are known to have an immune-modulation role in immune-mediated diseases.

Original languageEnglish
Pages (from-to)693-699
Number of pages7
JournalParasitology Research
Volume118
Issue number2
DOIs
Publication statusPublished - 2019 Feb 14

Fingerprint

Clonorchis sinensis
liver flukes
Fasciola hepatica
Probiotics
Lactobacillus
probiotics
Immune System Diseases
digestive system
Helminths
Microbiota
mice
Infection
infection
Metacercariae
Control Groups
helminthiasis
species diversity
Inbred C57BL Mouse
metacercariae
Immune System

All Science Journal Classification (ASJC) codes

  • Parasitology
  • veterinary(all)
  • Insect Science
  • Infectious Diseases

Cite this

Kim, Ju Yeong ; Kim, Eun Min ; Yi, Myung hee ; Lee, Jinyoung ; Lee, Seogwon ; Hwang, Younjee ; Yong, DongEun ; Sohn, Woon Mok ; Yong, Taisoon. / Chinese liver fluke Clonorchis sinensis infection changes the gut microbiome and increases probiotic Lactobacillus in mice. In: Parasitology Research. 2019 ; Vol. 118, No. 2. pp. 693-699.
@article{cc1f57a2d5d0405584d726283e1a8271,
title = "Chinese liver fluke Clonorchis sinensis infection changes the gut microbiome and increases probiotic Lactobacillus in mice",
abstract = "Chinese liver fluke Clonorchis sinensis changes the host’s immune system. Recently, it has been reported that helminths including C. sinensis can ameliorate immune-related diseases such as allergy. In addition, recent studies showed that helminth infection can alleviate immune-mediated disorders by altering the gut microbiome. However, changes in the gut microbiome due to C. sinensis have not been reported yet. In this study, changes in the gut microbiome of C57BL/6 mice infected with C. sinensis metacercariae were evaluated over time. Stool was analyzed by 16S rRNA amplicon analysis using high-throughput sequencing technology. There was no apparent difference in species richness and diversity between the infected and control groups. However, the composition of the microbiome was different between the infected and control groups at 20 days and 30 days post-infection, and the difference disappeared at 50 days post-infection. In particular, this microbiome alteration was associated with a change in the relative abundance of genus Lactobacillus and the probiotic Lactobacillus species that are known to have an immune-modulation role in immune-mediated diseases.",
author = "Kim, {Ju Yeong} and Kim, {Eun Min} and Yi, {Myung hee} and Jinyoung Lee and Seogwon Lee and Younjee Hwang and DongEun Yong and Sohn, {Woon Mok} and Taisoon Yong",
year = "2019",
month = "2",
day = "14",
doi = "10.1007/s00436-018-6179-x",
language = "English",
volume = "118",
pages = "693--699",
journal = "Parasitology Research",
issn = "0932-0113",
publisher = "Springer Verlag",
number = "2",

}

Chinese liver fluke Clonorchis sinensis infection changes the gut microbiome and increases probiotic Lactobacillus in mice. / Kim, Ju Yeong; Kim, Eun Min; Yi, Myung hee; Lee, Jinyoung; Lee, Seogwon; Hwang, Younjee; Yong, DongEun; Sohn, Woon Mok; Yong, Taisoon.

In: Parasitology Research, Vol. 118, No. 2, 14.02.2019, p. 693-699.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Chinese liver fluke Clonorchis sinensis infection changes the gut microbiome and increases probiotic Lactobacillus in mice

AU - Kim, Ju Yeong

AU - Kim, Eun Min

AU - Yi, Myung hee

AU - Lee, Jinyoung

AU - Lee, Seogwon

AU - Hwang, Younjee

AU - Yong, DongEun

AU - Sohn, Woon Mok

AU - Yong, Taisoon

PY - 2019/2/14

Y1 - 2019/2/14

N2 - Chinese liver fluke Clonorchis sinensis changes the host’s immune system. Recently, it has been reported that helminths including C. sinensis can ameliorate immune-related diseases such as allergy. In addition, recent studies showed that helminth infection can alleviate immune-mediated disorders by altering the gut microbiome. However, changes in the gut microbiome due to C. sinensis have not been reported yet. In this study, changes in the gut microbiome of C57BL/6 mice infected with C. sinensis metacercariae were evaluated over time. Stool was analyzed by 16S rRNA amplicon analysis using high-throughput sequencing technology. There was no apparent difference in species richness and diversity between the infected and control groups. However, the composition of the microbiome was different between the infected and control groups at 20 days and 30 days post-infection, and the difference disappeared at 50 days post-infection. In particular, this microbiome alteration was associated with a change in the relative abundance of genus Lactobacillus and the probiotic Lactobacillus species that are known to have an immune-modulation role in immune-mediated diseases.

AB - Chinese liver fluke Clonorchis sinensis changes the host’s immune system. Recently, it has been reported that helminths including C. sinensis can ameliorate immune-related diseases such as allergy. In addition, recent studies showed that helminth infection can alleviate immune-mediated disorders by altering the gut microbiome. However, changes in the gut microbiome due to C. sinensis have not been reported yet. In this study, changes in the gut microbiome of C57BL/6 mice infected with C. sinensis metacercariae were evaluated over time. Stool was analyzed by 16S rRNA amplicon analysis using high-throughput sequencing technology. There was no apparent difference in species richness and diversity between the infected and control groups. However, the composition of the microbiome was different between the infected and control groups at 20 days and 30 days post-infection, and the difference disappeared at 50 days post-infection. In particular, this microbiome alteration was associated with a change in the relative abundance of genus Lactobacillus and the probiotic Lactobacillus species that are known to have an immune-modulation role in immune-mediated diseases.

UR - http://www.scopus.com/inward/record.url?scp=85059762300&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85059762300&partnerID=8YFLogxK

U2 - 10.1007/s00436-018-6179-x

DO - 10.1007/s00436-018-6179-x

M3 - Article

C2 - 30623233

AN - SCOPUS:85059762300

VL - 118

SP - 693

EP - 699

JO - Parasitology Research

JF - Parasitology Research

SN - 0932-0113

IS - 2

ER -