Chios mastic gum extracts as a potent antitumor agent that inhibits growth and induces apoptosis of oral cancer cells

Sheng Jin Li, In Ho Cha, Woong Nam

Research output: Contribution to journalArticlepeer-review

8 Citations (Scopus)

Abstract

Purpose: The purpose was to investigate Chios mastic gum (CMG) extract as an potential anti-tumor agent for oral squamous cell carcinoma in vitro. Methods: We designed a study to examine the effects of CMG extracts on growth of oral squamous cell carcinoma cell line, YD-10B and to determine whether the extracts could induce apoptosis through the activation of caspase-3, using the common chemotherapeutic agent Paclitaxel (Taxol, Bristol-Myers Squibb) as a control. Results: MTT assay suggested that both CMG and Taxol inhibited the proliferation of YD-10B cells in a time and dose dependent manner. Moreover, 10μg/mL of CMG and 50μg/mL of Taxol caused fragmentation of the genomic DNA at 24 hour. Finally, 10μg/mL of CMG and 50μg/mL of Taxol caused cleavage of procaspase-3 in western blot analysis. Conclusions: These results suggest CMG's potential as an anti-tumor agent.

Original languageEnglish
Pages (from-to)1877-1880
Number of pages4
JournalAsian Pacific Journal of Cancer Prevention
Volume12
Issue number7
Publication statusPublished - 2011

All Science Journal Classification (ASJC) codes

  • Epidemiology
  • Oncology
  • Public Health, Environmental and Occupational Health
  • Cancer Research

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