Chiroptical properties of anionic and cationic porphyrins and metalloporphyrins in complex with left-handed Z-DNA and right-handed B-DNA

Jung Kyu Choi; Alessandro D'Urso; Milan Balaz

doi:10.1016/j.jinorgbio.2013.05.018

Chiroptical properties of anionic and cationic porphyrins and metalloporphyrins in complex with left-handed Z-DNA and right-handed B-DNA

Jung Kyu Choi, Alessandro D'Urso, Milan Balaz

Integrated Sciences and Engineering Division

Research output: Contribution to journal › Article › peer-review

22 Citations (Scopus)

Abstract

We report the chiroptical signature and binding interactions of cationic (meso-tetrakis(4-N-methylptridyl)porphyrin, 2HT4) and anionic (meso-tetrakis(4-sulfonatophenyl)porphyrin, 2HTPPS) porphyrins and their zinc(II) and nickel(II) derivatives (ZnT4, ZnTPPS, NiT4, and NiTPPS) with right-handed B-form and two forms of left-handed Z-form of alternating guanine-cytosine polydeoxynucleotide poly(dG-dC)₂. NiTPPS is able to spectroscopically discriminate between spermine-induced Z-DNA and Co(III)-induced Z-DNA via new induced circular dichroism signal in the visible region of the electromagnetic spectrum.

Original language	English
Pages (from-to)	1-6
Number of pages	6
Journal	Journal of Inorganic Biochemistry
Volume	127
DOIs	https://doi.org/10.1016/j.jinorgbio.2013.05.018
Publication status	Published - 2013

Bibliographical note

Funding Information:
This research was supported by University of Wyoming start-up funds. AD'U thanks University of Catania for financial support.

All Science Journal Classification (ASJC) codes

Biochemistry
Inorganic Chemistry

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title = "Chiroptical properties of anionic and cationic porphyrins and metalloporphyrins in complex with left-handed Z-DNA and right-handed B-DNA",

abstract = "We report the chiroptical signature and binding interactions of cationic (meso-tetrakis(4-N-methylptridyl)porphyrin, 2HT4) and anionic (meso-tetrakis(4-sulfonatophenyl)porphyrin, 2HTPPS) porphyrins and their zinc(II) and nickel(II) derivatives (ZnT4, ZnTPPS, NiT4, and NiTPPS) with right-handed B-form and two forms of left-handed Z-form of alternating guanine-cytosine polydeoxynucleotide poly(dG-dC)2. NiTPPS is able to spectroscopically discriminate between spermine-induced Z-DNA and Co(III)-induced Z-DNA via new induced circular dichroism signal in the visible region of the electromagnetic spectrum.",

author = "Choi, {Jung Kyu} and Alessandro D'Urso and Milan Balaz",

note = "Funding Information: This research was supported by University of Wyoming start-up funds. AD'U thanks University of Catania for financial support. ",

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doi = "10.1016/j.jinorgbio.2013.05.018",

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AU - Choi, Jung Kyu

AU - D'Urso, Alessandro

AU - Balaz, Milan

N1 - Funding Information: This research was supported by University of Wyoming start-up funds. AD'U thanks University of Catania for financial support.

PY - 2013

Y1 - 2013

N2 - We report the chiroptical signature and binding interactions of cationic (meso-tetrakis(4-N-methylptridyl)porphyrin, 2HT4) and anionic (meso-tetrakis(4-sulfonatophenyl)porphyrin, 2HTPPS) porphyrins and their zinc(II) and nickel(II) derivatives (ZnT4, ZnTPPS, NiT4, and NiTPPS) with right-handed B-form and two forms of left-handed Z-form of alternating guanine-cytosine polydeoxynucleotide poly(dG-dC)2. NiTPPS is able to spectroscopically discriminate between spermine-induced Z-DNA and Co(III)-induced Z-DNA via new induced circular dichroism signal in the visible region of the electromagnetic spectrum.

AB - We report the chiroptical signature and binding interactions of cationic (meso-tetrakis(4-N-methylptridyl)porphyrin, 2HT4) and anionic (meso-tetrakis(4-sulfonatophenyl)porphyrin, 2HTPPS) porphyrins and their zinc(II) and nickel(II) derivatives (ZnT4, ZnTPPS, NiT4, and NiTPPS) with right-handed B-form and two forms of left-handed Z-form of alternating guanine-cytosine polydeoxynucleotide poly(dG-dC)2. NiTPPS is able to spectroscopically discriminate between spermine-induced Z-DNA and Co(III)-induced Z-DNA via new induced circular dichroism signal in the visible region of the electromagnetic spectrum.

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Chiroptical properties of anionic and cationic porphyrins and metalloporphyrins in complex with left-handed Z-DNA and right-handed B-DNA

Abstract

Bibliographical note

All Science Journal Classification (ASJC) codes

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