Chitosan-Alginate-Pectin-coated Suspended-Liquid-Encapsulating (CAPSuLE) marbles for therapeutic agent storage and delivery

Yoojin Kim, Seokmin Oh, Heehyung Lee, Dongsoo Lee, Mihyun Kim, Heung Soo Baek, Won Seok Park, Eunmi Kim, Jae Hyung Jang

Research output: Contribution to journalArticlepeer-review

1 Citation (Scopus)


Developing a cutting-edge system capable of ensuring long-lasting functionality of therapeutic agents and implementing diverse delivery modes is challenging. A quasi-spherical triple-layered capsule containing suspended liquid droplets and allowing multi-modal delivery of therapeutic agents in the aqueous phase was developed, primarily by adopting the core principles for creating liquid marbles. A naturally derived wettable polysaccharide - pectin - was utilized as a liquid-air interfacial barrier to keep the liquid droplets in the core zone. To tailor the pectin-coated droplet as a therapeutic agent carrier, anionic alginate and cationic chitosan layers were sequentially formed via additional interactions: physically stacking substances with structural chirality (pectin-alginate) and inducing electrostatic association to create the reversible complex coacervates (alginate-chitosan). The resulting system, which is called a Chitosan-Alginate-Pectin-coated Suspended-Liquid-Encapsulating (CAPSuLE) marble, had sufficient mechanical strength to resist external harsh environments and exhibited unique features: ecofriendly sustainability, responsiveness to external stimuli, coacervate-driven coalescence for linking adjacent marbles, and a self-repairing ability. The proposed CAPSuLE system can facilitate the adoption of the liquid-marble concept to biomedical fields, extending its applicability in the fields of biology and applied engineering.

Original languageEnglish
Pages (from-to)1639-1651
Number of pages13
JournalBiomaterials Science
Issue number5
Publication statusPublished - 2021 Mar 7

Bibliographical note

Publisher Copyright:
© The Royal Society of Chemistry.

All Science Journal Classification (ASJC) codes

  • Biomedical Engineering
  • Materials Science(all)


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