Cholesterol-derived novel anti-apoptotic agents on the structural basis of ginsenoside Rk1

Sujin Lee, Sony Maharjan, Kyeojin Kim, Nam Jung Kim, Hyun Jung Choi, Young-Guen Kwon, Young Ger Suh

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

Design and synthesis of cholesterol-derived anti-apoptotic agents were described. The synthesized cholesterol analogs designed on the structural basis of ginsenoside Rk1 inhibited the undesirable apoptosis of human endothelial cells, which are induced by a vascular injury. In particular, analogue 1 possessing 4,6-di-O-acetyl-2,3-dideoxyhex-2-enopyran linked to hydroxyl group of cholesterol exhibited the most effective anti-apoptotic activities at both 5 and 10 μg/ml.

Original languageEnglish
Pages (from-to)7102-7105
Number of pages4
JournalBioorganic and Medicinal Chemistry Letters
Volume20
Issue number23
DOIs
Publication statusPublished - 2010 Dec 1

Fingerprint

Cholesterol
Vascular System Injuries
Endothelial cells
Hydroxyl Radical
Endothelial Cells
Apoptosis
ginsenoside Rk1

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Molecular Medicine
  • Molecular Biology
  • Pharmaceutical Science
  • Drug Discovery
  • Clinical Biochemistry
  • Organic Chemistry

Cite this

Lee, Sujin ; Maharjan, Sony ; Kim, Kyeojin ; Kim, Nam Jung ; Choi, Hyun Jung ; Kwon, Young-Guen ; Suh, Young Ger. / Cholesterol-derived novel anti-apoptotic agents on the structural basis of ginsenoside Rk1. In: Bioorganic and Medicinal Chemistry Letters. 2010 ; Vol. 20, No. 23. pp. 7102-7105.
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Cholesterol-derived novel anti-apoptotic agents on the structural basis of ginsenoside Rk1. / Lee, Sujin; Maharjan, Sony; Kim, Kyeojin; Kim, Nam Jung; Choi, Hyun Jung; Kwon, Young-Guen; Suh, Young Ger.

In: Bioorganic and Medicinal Chemistry Letters, Vol. 20, No. 23, 01.12.2010, p. 7102-7105.

Research output: Contribution to journalArticle

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AU - Kwon, Young-Guen

AU - Suh, Young Ger

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