Choroidal thickness in Behcet's uveitis: An enhanced depth imaging-optical coherence tomography and its association with angiographic changes

Min Kim, Hyesun Kim, Hee Jung Kwon, Sung Soo Kim, Hyoung Jun Koh, Sung Chul Lee

Research output: Contribution to journalArticle

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Abstract

PURPOSE. To evaluate the change in subfoveal choroidal thickness between active and quiescent phases of Behcet's posterior uveitis and compare this with the healthy population using enhanced depth imaging optical coherence tomography (EDI-OCT). METHODS. Thirty eyes from 30 patients with Behcet's posterior uveitis (mean age, 47.03 6 11.01 years) were retrospectively enrolled in the study. Their subfoveal choroidal thickness was measured using EDI-OCT in the active and quiescent phases of Behcet's uveitis, and compared with the age, sex, and spherical equivalent-matched healthy population. Changes in retinal vascular leakage on fluorescein angiography (FA) were correlated with the changes in subfoveal choroidal thickness. RESULTS. Mean subfoveal choroidal thickness in the acute phase of Behcet's uveitis was significantly greater than that in the quiescent phase (398.77 6 155.59 lm versus 356.72 6 141.09 lm; P 1/4 0.004). Subfoveal choroidal thickness in the quiescent phase was also significantly greater than that of the healthy population (259.96 6 65.16 lm; P < 0.0001). There was a statistically significant association between the change in subfoveal choroidal thickness and the change in vascular leakage revealed by FA (q 1/4 0.381, P 1/4 0.046). Subfoveal choroidal thickness in the uninvolved fellow eyes of patients with unilateral Behcet's uveitis was also evaluated and it was significantly greater than that of the healthy population (n 1/4 13 eyes; P 1/4 0.001) CONCLUSIONS. This study found choroidal thickening during the active phase of Behcet's posterior uveitis. Subfoveal choroidal thickness during the quiescent phase was also significantly greater than in normal eyes. The degree of reduction in choroidal thickening was significantly correlated with improvement in retinal vascular leakage as revealed by FA.

Original languageEnglish
Pages (from-to)6033-6039
Number of pages7
JournalInvestigative Ophthalmology and Visual Science
Volume54
Issue number9
DOIs
Publication statusPublished - 2013 Sep 13

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Uveitis
Posterior Uveitis
Optical Coherence Tomography
Fluorescein Angiography
Retinal Vessels
Population
Blood Vessels

All Science Journal Classification (ASJC) codes

  • Ophthalmology
  • Sensory Systems
  • Cellular and Molecular Neuroscience

Cite this

@article{7184bbe97ca944debbb8a86b0b28e783,
title = "Choroidal thickness in Behcet's uveitis: An enhanced depth imaging-optical coherence tomography and its association with angiographic changes",
abstract = "PURPOSE. To evaluate the change in subfoveal choroidal thickness between active and quiescent phases of Behcet's posterior uveitis and compare this with the healthy population using enhanced depth imaging optical coherence tomography (EDI-OCT). METHODS. Thirty eyes from 30 patients with Behcet's posterior uveitis (mean age, 47.03 6 11.01 years) were retrospectively enrolled in the study. Their subfoveal choroidal thickness was measured using EDI-OCT in the active and quiescent phases of Behcet's uveitis, and compared with the age, sex, and spherical equivalent-matched healthy population. Changes in retinal vascular leakage on fluorescein angiography (FA) were correlated with the changes in subfoveal choroidal thickness. RESULTS. Mean subfoveal choroidal thickness in the acute phase of Behcet's uveitis was significantly greater than that in the quiescent phase (398.77 6 155.59 lm versus 356.72 6 141.09 lm; P 1/4 0.004). Subfoveal choroidal thickness in the quiescent phase was also significantly greater than that of the healthy population (259.96 6 65.16 lm; P < 0.0001). There was a statistically significant association between the change in subfoveal choroidal thickness and the change in vascular leakage revealed by FA (q 1/4 0.381, P 1/4 0.046). Subfoveal choroidal thickness in the uninvolved fellow eyes of patients with unilateral Behcet's uveitis was also evaluated and it was significantly greater than that of the healthy population (n 1/4 13 eyes; P 1/4 0.001) CONCLUSIONS. This study found choroidal thickening during the active phase of Behcet's posterior uveitis. Subfoveal choroidal thickness during the quiescent phase was also significantly greater than in normal eyes. The degree of reduction in choroidal thickening was significantly correlated with improvement in retinal vascular leakage as revealed by FA.",
author = "Min Kim and Hyesun Kim and Kwon, {Hee Jung} and Kim, {Sung Soo} and Koh, {Hyoung Jun} and Lee, {Sung Chul}",
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Choroidal thickness in Behcet's uveitis : An enhanced depth imaging-optical coherence tomography and its association with angiographic changes. / Kim, Min; Kim, Hyesun; Kwon, Hee Jung; Kim, Sung Soo; Koh, Hyoung Jun; Lee, Sung Chul.

In: Investigative Ophthalmology and Visual Science, Vol. 54, No. 9, 13.09.2013, p. 6033-6039.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Choroidal thickness in Behcet's uveitis

T2 - An enhanced depth imaging-optical coherence tomography and its association with angiographic changes

AU - Kim, Min

AU - Kim, Hyesun

AU - Kwon, Hee Jung

AU - Kim, Sung Soo

AU - Koh, Hyoung Jun

AU - Lee, Sung Chul

PY - 2013/9/13

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N2 - PURPOSE. To evaluate the change in subfoveal choroidal thickness between active and quiescent phases of Behcet's posterior uveitis and compare this with the healthy population using enhanced depth imaging optical coherence tomography (EDI-OCT). METHODS. Thirty eyes from 30 patients with Behcet's posterior uveitis (mean age, 47.03 6 11.01 years) were retrospectively enrolled in the study. Their subfoveal choroidal thickness was measured using EDI-OCT in the active and quiescent phases of Behcet's uveitis, and compared with the age, sex, and spherical equivalent-matched healthy population. Changes in retinal vascular leakage on fluorescein angiography (FA) were correlated with the changes in subfoveal choroidal thickness. RESULTS. Mean subfoveal choroidal thickness in the acute phase of Behcet's uveitis was significantly greater than that in the quiescent phase (398.77 6 155.59 lm versus 356.72 6 141.09 lm; P 1/4 0.004). Subfoveal choroidal thickness in the quiescent phase was also significantly greater than that of the healthy population (259.96 6 65.16 lm; P < 0.0001). There was a statistically significant association between the change in subfoveal choroidal thickness and the change in vascular leakage revealed by FA (q 1/4 0.381, P 1/4 0.046). Subfoveal choroidal thickness in the uninvolved fellow eyes of patients with unilateral Behcet's uveitis was also evaluated and it was significantly greater than that of the healthy population (n 1/4 13 eyes; P 1/4 0.001) CONCLUSIONS. This study found choroidal thickening during the active phase of Behcet's posterior uveitis. Subfoveal choroidal thickness during the quiescent phase was also significantly greater than in normal eyes. The degree of reduction in choroidal thickening was significantly correlated with improvement in retinal vascular leakage as revealed by FA.

AB - PURPOSE. To evaluate the change in subfoveal choroidal thickness between active and quiescent phases of Behcet's posterior uveitis and compare this with the healthy population using enhanced depth imaging optical coherence tomography (EDI-OCT). METHODS. Thirty eyes from 30 patients with Behcet's posterior uveitis (mean age, 47.03 6 11.01 years) were retrospectively enrolled in the study. Their subfoveal choroidal thickness was measured using EDI-OCT in the active and quiescent phases of Behcet's uveitis, and compared with the age, sex, and spherical equivalent-matched healthy population. Changes in retinal vascular leakage on fluorescein angiography (FA) were correlated with the changes in subfoveal choroidal thickness. RESULTS. Mean subfoveal choroidal thickness in the acute phase of Behcet's uveitis was significantly greater than that in the quiescent phase (398.77 6 155.59 lm versus 356.72 6 141.09 lm; P 1/4 0.004). Subfoveal choroidal thickness in the quiescent phase was also significantly greater than that of the healthy population (259.96 6 65.16 lm; P < 0.0001). There was a statistically significant association between the change in subfoveal choroidal thickness and the change in vascular leakage revealed by FA (q 1/4 0.381, P 1/4 0.046). Subfoveal choroidal thickness in the uninvolved fellow eyes of patients with unilateral Behcet's uveitis was also evaluated and it was significantly greater than that of the healthy population (n 1/4 13 eyes; P 1/4 0.001) CONCLUSIONS. This study found choroidal thickening during the active phase of Behcet's posterior uveitis. Subfoveal choroidal thickness during the quiescent phase was also significantly greater than in normal eyes. The degree of reduction in choroidal thickening was significantly correlated with improvement in retinal vascular leakage as revealed by FA.

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