Chronic alcohol intake differently influences glucose metabolism according to nutritional status

Bong Soo Cha, Chul Woo Ahn, Young Duk Song, Sung Kil Lim, Kyung Rae Kim, Kap Bum Huh, Hyun Chul Lee

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

We investigated the potential different effects of a chronic alcohol intake on glucose metabolism according to nutritional status in growing rats. Eighty weanling 4-week-old male Sprague Dawley rats were fed with low (5%, wt/wt) or control (22%) protein diet for 8 weeks. Each group was subdivided into alcohol (5 g/kg-1·day-1) or saline gavage rats during the last 4 weeks. At 12 weeks of age, we measured the weights of the body, pancreas, and epididymal fat; glycogen synthase activity of gastrocnemius muscle; and insulin content of the pancreas. We performed an ip glucose tolerance test and a euglycemic hyperinsulinemic clamp test. Weight gain was almost arrested in protein-deficient rats. The relative weight and insulin content of the pancreas and glycogen synthase activity were not different among the four groups, but the relative amount of epididymal fat decreased only in protein-deficient saline rats. Insulin response after glucose challenge and glucose disposal rate during the euglycemic clamp were both markedly decreased in protein-deficient saline rats, but not changed in protein-deficient alcohol rats. Protein-deficiency per se causes deterioration both in insulin secretory function and in sensitivity, but these defects are protected by a chronic alcohol intake. In a protein-sufficient state, alcohol intake gives no additional effects on glucose metabolism. Therefore, according to individual nutritional status, the metabolic effect of alcohol intake appears differently.

Original languageEnglish
Pages (from-to)3646-3652
Number of pages7
JournalJournal of Clinical Endocrinology and Metabolism
Volume85
Issue number10
DOIs
Publication statusPublished - 2000 Jan 1

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Nutritional Status
Metabolism
Rats
Alcohols
Glucose
Insulin
Pancreas
Glycogen Synthase
Proteins
Glucose Clamp Technique
Clamping devices
Fats
Protein Deficiency
Glucose Tolerance Test
Weight Gain
Nutrition
Sprague Dawley Rats
Skeletal Muscle
Deterioration
Muscle

All Science Journal Classification (ASJC) codes

  • Endocrinology, Diabetes and Metabolism
  • Biochemistry
  • Endocrinology
  • Clinical Biochemistry
  • Biochemistry, medical

Cite this

Cha, Bong Soo ; Ahn, Chul Woo ; Song, Young Duk ; Lim, Sung Kil ; Kim, Kyung Rae ; Huh, Kap Bum ; Lee, Hyun Chul. / Chronic alcohol intake differently influences glucose metabolism according to nutritional status. In: Journal of Clinical Endocrinology and Metabolism. 2000 ; Vol. 85, No. 10. pp. 3646-3652.
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Chronic alcohol intake differently influences glucose metabolism according to nutritional status. / Cha, Bong Soo; Ahn, Chul Woo; Song, Young Duk; Lim, Sung Kil; Kim, Kyung Rae; Huh, Kap Bum; Lee, Hyun Chul.

In: Journal of Clinical Endocrinology and Metabolism, Vol. 85, No. 10, 01.01.2000, p. 3646-3652.

Research output: Contribution to journalArticle

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