Chronic chorioamnionitis is the most common placental lesion in late preterm birth

JoonHo Lee, J. S. Kim, J. W. Park, C. W. Park, J. S. Park, J. K. Jun, B. H. Yoon

Research output: Contribution to journalArticle

40 Citations (Scopus)

Abstract

Objectives: The pathogenesis of late preterm birth remains elusive for the mechanisms of disease responsible. Placental examination can often provide important clues for the pathogenesis of pregnancy complications. This study was conducted to determine placental pathologic findings according to the gestational age and the clinical circumstances of preterm birth. Study design: Placental pathologic findings and obstetrical and neonatal outcomes were reviewed in a consecutive preterm birth cohort from a single tertiary center (N = 1206). Placentas of term births (N = 300) were used as normal controls. Results: Acute chorioamnionitis (22.7% vs. 16.7%), maternal vascular underperfusion (6.4% vs. 0.5%), and chronic chorioamnionitis (20.8% vs. 10.5%) were significantly more frequent in preterm births than in term births (P < 0.05, for each). Among preterm births, chronic chorioamnionitis was the most common pathology of late preterm birth (gestational age <37 and ≥34 weeks), while acute chorioamnionitis was the most common lesion of extremely preterm birth (gestational age <28 weeks). While the frequency of acute chorioamnionitis decreased with advancing gestation, that of chronic chorioamnionitis increased (P < 0.001, for each). The upward trend of the frequency of chronic chorioamnionitis was related to advancing gestation in both spontaneous and indicated preterm births (P < 0.001, for each). Conclusions: Chronic chorioamnionitis is a common pathology of late preterm birth. It is suggested that chronic chorioamnionitis, a feature of maternal anti-fetal rejection, is an important etiology of preterm birth, especially of late preterm birth.

Original languageEnglish
Pages (from-to)681-689
Number of pages9
JournalPlacenta
Volume34
Issue number8
DOIs
Publication statusPublished - 2013 Jan 1

Fingerprint

Chorioamnionitis
Premature Birth
Term Birth
Gestational Age
Mothers
Pathology
Pregnancy
Pregnancy Complications
Placenta
Blood Vessels

All Science Journal Classification (ASJC) codes

  • Reproductive Medicine
  • Obstetrics and Gynaecology
  • Developmental Biology

Cite this

Lee, J., Kim, J. S., Park, J. W., Park, C. W., Park, J. S., Jun, J. K., & Yoon, B. H. (2013). Chronic chorioamnionitis is the most common placental lesion in late preterm birth. Placenta, 34(8), 681-689. https://doi.org/10.1016/j.placenta.2013.04.014
Lee, JoonHo ; Kim, J. S. ; Park, J. W. ; Park, C. W. ; Park, J. S. ; Jun, J. K. ; Yoon, B. H. / Chronic chorioamnionitis is the most common placental lesion in late preterm birth. In: Placenta. 2013 ; Vol. 34, No. 8. pp. 681-689.
@article{1f2f3af62c414d7fb59af70248c668bc,
title = "Chronic chorioamnionitis is the most common placental lesion in late preterm birth",
abstract = "Objectives: The pathogenesis of late preterm birth remains elusive for the mechanisms of disease responsible. Placental examination can often provide important clues for the pathogenesis of pregnancy complications. This study was conducted to determine placental pathologic findings according to the gestational age and the clinical circumstances of preterm birth. Study design: Placental pathologic findings and obstetrical and neonatal outcomes were reviewed in a consecutive preterm birth cohort from a single tertiary center (N = 1206). Placentas of term births (N = 300) were used as normal controls. Results: Acute chorioamnionitis (22.7{\%} vs. 16.7{\%}), maternal vascular underperfusion (6.4{\%} vs. 0.5{\%}), and chronic chorioamnionitis (20.8{\%} vs. 10.5{\%}) were significantly more frequent in preterm births than in term births (P < 0.05, for each). Among preterm births, chronic chorioamnionitis was the most common pathology of late preterm birth (gestational age <37 and ≥34 weeks), while acute chorioamnionitis was the most common lesion of extremely preterm birth (gestational age <28 weeks). While the frequency of acute chorioamnionitis decreased with advancing gestation, that of chronic chorioamnionitis increased (P < 0.001, for each). The upward trend of the frequency of chronic chorioamnionitis was related to advancing gestation in both spontaneous and indicated preterm births (P < 0.001, for each). Conclusions: Chronic chorioamnionitis is a common pathology of late preterm birth. It is suggested that chronic chorioamnionitis, a feature of maternal anti-fetal rejection, is an important etiology of preterm birth, especially of late preterm birth.",
author = "JoonHo Lee and Kim, {J. S.} and Park, {J. W.} and Park, {C. W.} and Park, {J. S.} and Jun, {J. K.} and Yoon, {B. H.}",
year = "2013",
month = "1",
day = "1",
doi = "10.1016/j.placenta.2013.04.014",
language = "English",
volume = "34",
pages = "681--689",
journal = "Placenta",
issn = "0143-4004",
publisher = "W.B. Saunders Ltd",
number = "8",

}

Lee, J, Kim, JS, Park, JW, Park, CW, Park, JS, Jun, JK & Yoon, BH 2013, 'Chronic chorioamnionitis is the most common placental lesion in late preterm birth', Placenta, vol. 34, no. 8, pp. 681-689. https://doi.org/10.1016/j.placenta.2013.04.014

Chronic chorioamnionitis is the most common placental lesion in late preterm birth. / Lee, JoonHo; Kim, J. S.; Park, J. W.; Park, C. W.; Park, J. S.; Jun, J. K.; Yoon, B. H.

In: Placenta, Vol. 34, No. 8, 01.01.2013, p. 681-689.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Chronic chorioamnionitis is the most common placental lesion in late preterm birth

AU - Lee, JoonHo

AU - Kim, J. S.

AU - Park, J. W.

AU - Park, C. W.

AU - Park, J. S.

AU - Jun, J. K.

AU - Yoon, B. H.

PY - 2013/1/1

Y1 - 2013/1/1

N2 - Objectives: The pathogenesis of late preterm birth remains elusive for the mechanisms of disease responsible. Placental examination can often provide important clues for the pathogenesis of pregnancy complications. This study was conducted to determine placental pathologic findings according to the gestational age and the clinical circumstances of preterm birth. Study design: Placental pathologic findings and obstetrical and neonatal outcomes were reviewed in a consecutive preterm birth cohort from a single tertiary center (N = 1206). Placentas of term births (N = 300) were used as normal controls. Results: Acute chorioamnionitis (22.7% vs. 16.7%), maternal vascular underperfusion (6.4% vs. 0.5%), and chronic chorioamnionitis (20.8% vs. 10.5%) were significantly more frequent in preterm births than in term births (P < 0.05, for each). Among preterm births, chronic chorioamnionitis was the most common pathology of late preterm birth (gestational age <37 and ≥34 weeks), while acute chorioamnionitis was the most common lesion of extremely preterm birth (gestational age <28 weeks). While the frequency of acute chorioamnionitis decreased with advancing gestation, that of chronic chorioamnionitis increased (P < 0.001, for each). The upward trend of the frequency of chronic chorioamnionitis was related to advancing gestation in both spontaneous and indicated preterm births (P < 0.001, for each). Conclusions: Chronic chorioamnionitis is a common pathology of late preterm birth. It is suggested that chronic chorioamnionitis, a feature of maternal anti-fetal rejection, is an important etiology of preterm birth, especially of late preterm birth.

AB - Objectives: The pathogenesis of late preterm birth remains elusive for the mechanisms of disease responsible. Placental examination can often provide important clues for the pathogenesis of pregnancy complications. This study was conducted to determine placental pathologic findings according to the gestational age and the clinical circumstances of preterm birth. Study design: Placental pathologic findings and obstetrical and neonatal outcomes were reviewed in a consecutive preterm birth cohort from a single tertiary center (N = 1206). Placentas of term births (N = 300) were used as normal controls. Results: Acute chorioamnionitis (22.7% vs. 16.7%), maternal vascular underperfusion (6.4% vs. 0.5%), and chronic chorioamnionitis (20.8% vs. 10.5%) were significantly more frequent in preterm births than in term births (P < 0.05, for each). Among preterm births, chronic chorioamnionitis was the most common pathology of late preterm birth (gestational age <37 and ≥34 weeks), while acute chorioamnionitis was the most common lesion of extremely preterm birth (gestational age <28 weeks). While the frequency of acute chorioamnionitis decreased with advancing gestation, that of chronic chorioamnionitis increased (P < 0.001, for each). The upward trend of the frequency of chronic chorioamnionitis was related to advancing gestation in both spontaneous and indicated preterm births (P < 0.001, for each). Conclusions: Chronic chorioamnionitis is a common pathology of late preterm birth. It is suggested that chronic chorioamnionitis, a feature of maternal anti-fetal rejection, is an important etiology of preterm birth, especially of late preterm birth.

UR - http://www.scopus.com/inward/record.url?scp=84882449105&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84882449105&partnerID=8YFLogxK

U2 - 10.1016/j.placenta.2013.04.014

DO - 10.1016/j.placenta.2013.04.014

M3 - Article

C2 - 23684379

AN - SCOPUS:84882449105

VL - 34

SP - 681

EP - 689

JO - Placenta

JF - Placenta

SN - 0143-4004

IS - 8

ER -