Chronic hepatitis B infection is significantly associated with chronic kidney disease: A population-based, matched case-control study

Sung Eun Kim, Eun Sun Jang, Moran Ki, Geum Youn Gwak, Kyung Ah Kim, Gi Ae Kim, Do Young Kim, Dong Joon Kim, Man Woo Kim, Yun Soo Kim, Young Seok Kim, In Hee Kim, Chang Wook Kim, Ho Dong Kim, Hyung Joon Kim, Neung Hwa Park, Soon Koo Baik, Jeong Ill Suh, Byung Cheol Song, Il Han SongJong Eun Yeon, Byung Seok Lee, Youn Jae Lee, Young Kul Jung, Woo Jin Chung, Sung Bum Cho, Eun Young Cho, Hyun Chin Cho, Gab Jin Cheon, Hee Bok Chae, Dae Hee Choi, Sung Kyu Choi, Hwa Young Choi, Won Young Tak, Jeong Heo, Sook Hyang Jeong

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12 Citations (Scopus)


Background: Hepatitis B virus (HBV) infection leads to hepatic and extrahepatic manifestations including chronic kidney disease (CKD). However, the association between HBV and CKD is not clear. This study investigated the association between chronic HBV infection and CKD in a nationwide multicenter study. Methods: A total of 265,086 subjects who underwent health-check examinations in 33 hospitals from January 2015 to December 2015 were enrolled. HBV surface antigen (HBsAg) positive cases (n = 10,048), and age- and gender-matched HBsAg negative controls (n = 40,192) were identified. CKD was defined as a glomerular filtration rate (GFR) < 60 mL/min/1.73 m2 or proteinuria as at least grade 2+ of urine protein. Results: HBsAg positive cases showed a significantly higher prevalence of GFR < 60 mL/min/1.73 m2 (3.3%), and proteinuria (18.9%) than that of the controls (2.6%, P < 0.001, and 14.1%, P < 0.001, respectively). In the multivariate analysis, HBsAg positivity was an independent factor associated with GFR < 60 mL/min/1.73 m2 along with age, blood levels of albumin, bilirubin, anemia, and hemoglobin A1c (HbA1c). Likewise, HBsAg positivity was an independent factor for proteinuria along with age, male, blood levels of bilirubin, protein, albumin, and HbA1c. A subgroup analysis showed that HBsAg positive men but not women had a significantly increased risk for GFR < 60 mL/min/1.73 m2. Conclusion: Chronic HBV infection was significantly associated with a GFR < 60 mL/min/1.73 m2 and proteinuria (≥ 2+). Therefore, clinical concern about CKD in chronic HBV infected patients, especially in male, is warranted.

Original languageEnglish
Article numbere264
JournalJournal of Korean medical science
Issue number42
Publication statusPublished - 2018 Oct 1

Bibliographical note

Funding Information:
This study was supported by a grant of the Korea Health Technology R&D Project through the Korea Health Industry Development Institute (KHIDI), funded by the Ministry of Health & Welfare, Republic of Korea (Grant No. HC15C1193).

Publisher Copyright:
© 2018 The Korean Academy of Medical Sciences.

All Science Journal Classification (ASJC) codes

  • Medicine(all)


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