Chronic inflammatory demyelinating polyneuropathy in children: A report of four patients with variable relapsing courses

Soo Jin Chang, Ji Hyun Lee, Shin Hye Kim, Joon Soo Lee, HeungDong Kim, Joon Won Kang, Young Mock Lee, hoonchul kang

Research output: Contribution to journalArticle

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Abstract

Chronic inflammatory demyelinating polyneuropathy (CIDP) is a chronically progressive or relapsing symmetric sensorimotor disorder presumed to occur because of immunologic antibody-mediated reactions. To understand the clinical courses of CIDP, we report variable CIDP courses in children with respect to initial presentation, responsiveness to medical treatment, and recurrence interval. Four patients who were diagnosed with acute-onset and relapsing CIDP courses at Severance Children’s Hospital, Seoul, Korea, were enrolled in this retrospective study. We diagnosed each patient on the basis of the CIDP diagnostic criteria developed in 2010 by the European Federation of Neurological Societies/Peripheral Nerve Society Guidelines. We present the cases of four pediatric patients diagnosed with CIDP to understand the variable clinical course of the disease in children. Our four patients were all between 8 and 12 years of age. Patients 1 and 2 were diagnosed with acute cerebellar ataxia or Guillain-Barré syndrome as initial symptoms. While patients 1 and 4 were given only intravenous dexamethasone (0.3 mg/kg/day) for 5 days at the first episode, Patients 2 and 3 were given a combination of intravenous immunoglobulin (2 g/kg) and dexamethasone (0.3 mg/kg/day). All patients were maintained with oral prednisolone at 30 mg/day, but their clinical courses were variable in both relapse intervals and severity. We experienced variable clinical courses of CIDP in children with respect to initial presentation, responsiveness to medical treatment, and recurrence interval.

Original languageEnglish
Pages (from-to)194-198
Number of pages5
JournalKorean Journal of Pediatrics
Volume58
Issue number5
DOIs
Publication statusPublished - 2015 Jan 1

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Chronic Inflammatory Demyelinating Polyradiculoneuropathy
Recurrence
Dexamethasone
Cerebellar Ataxia
Intravenous Immunoglobulins
Korea
Prednisolone
Retrospective Studies
Guidelines
Pediatrics
Antibodies

All Science Journal Classification (ASJC) codes

  • Pediatrics, Perinatology, and Child Health
  • Pediatrics

Cite this

Chang, Soo Jin ; Lee, Ji Hyun ; Kim, Shin Hye ; Lee, Joon Soo ; Kim, HeungDong ; Kang, Joon Won ; Lee, Young Mock ; kang, hoonchul. / Chronic inflammatory demyelinating polyneuropathy in children : A report of four patients with variable relapsing courses. In: Korean Journal of Pediatrics. 2015 ; Vol. 58, No. 5. pp. 194-198.
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Chronic inflammatory demyelinating polyneuropathy in children : A report of four patients with variable relapsing courses. / Chang, Soo Jin; Lee, Ji Hyun; Kim, Shin Hye; Lee, Joon Soo; Kim, HeungDong; Kang, Joon Won; Lee, Young Mock; kang, hoonchul.

In: Korean Journal of Pediatrics, Vol. 58, No. 5, 01.01.2015, p. 194-198.

Research output: Contribution to journalArticle

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