Chronic kidney disease with genitourinary tuberculosis: Old disease but ongoing complication

Eun Jin Kim, Woonji Lee, Woo Yong Jeong, Hen Choi, In Young Jung, Jin Young Ahn, Su Jin Jeong, Nam Su Ku, Jun Yong Choi, Young Hwa Choi, Young Goo Song, June Myung Kim

Research output: Contribution to journalArticle

Abstract

Background: Genitourinary tuberculosis (GUTB) is a type of extrapulmonary TB that exerts a deleterious effect on renal function by promoting renal calcification and ureteric stricture. Therefore, we investigated the risk factors for chronic kidney disease (CKD) in GUTB patients after the end of treatment. Methods: This retrospective study was conducted at a tertiary hospital in South Korea. Data from patients (>18 years of age) with GUTB were collected from January 2005 to July 2016. CKD was defined as a glomerular filtration rate <60 mL/min/1.73m 2 after the end of treatment. Results: In total, 56 patients with GUTB (46.4% males; mean age 52.8 ± 16.6 years) were enrolled in the study. CKD developed in 11 (19.6%) patients and end-stage renal disease in 4 (7.1%). In a univariate analysis, older age (p = 0.029), microscopic haematuria (p = 0.019), proteinuria (p = 0.029), acute renal failure (ARF) (p < 0.001) and a positive polymerase chain reaction-based test result for TB in the urine (p = 0.030) were significantly associated with decreased renal function. In a multivariate analysis, ARF (odds ratio [OR], 54.31; 95% confidence interval [CI], 1.52-1944.00; p = 0.032) and old age (OR, 54.26; 95% CI, 1.52-1932.94; p = 0.028) were independent risk factors for CKD in GUTB patients. Conclusions: ARF and old age were independent risk factors for CKD in GUTB patients. Therefore, in elderly GUTB patients with ARF at the time of diagnosis, regular follow-up of renal function should be performed even after the end of treatment.

Original languageEnglish
Article number193
JournalBMC Nephrology
Volume19
Issue number1
DOIs
Publication statusPublished - 2018 Aug 2

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Chronic Renal Insufficiency
Tuberculosis
Acute Kidney Injury
Kidney
Odds Ratio
Confidence Intervals
Republic of Korea
Hematuria
Glomerular Filtration Rate
Proteinuria
Tertiary Care Centers
Chronic Kidney Failure
Pathologic Constriction
Therapeutics
Multivariate Analysis
Retrospective Studies
Urine
Polymerase Chain Reaction

All Science Journal Classification (ASJC) codes

  • Nephrology

Cite this

Kim, E. J., Lee, W., Jeong, W. Y., Choi, H., Jung, I. Y., Ahn, J. Y., ... Kim, J. M. (2018). Chronic kidney disease with genitourinary tuberculosis: Old disease but ongoing complication. BMC Nephrology, 19(1), [193]. https://doi.org/10.1186/s12882-018-0994-2
Kim, Eun Jin ; Lee, Woonji ; Jeong, Woo Yong ; Choi, Hen ; Jung, In Young ; Ahn, Jin Young ; Jeong, Su Jin ; Ku, Nam Su ; Choi, Jun Yong ; Choi, Young Hwa ; Song, Young Goo ; Kim, June Myung. / Chronic kidney disease with genitourinary tuberculosis : Old disease but ongoing complication. In: BMC Nephrology. 2018 ; Vol. 19, No. 1.
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abstract = "Background: Genitourinary tuberculosis (GUTB) is a type of extrapulmonary TB that exerts a deleterious effect on renal function by promoting renal calcification and ureteric stricture. Therefore, we investigated the risk factors for chronic kidney disease (CKD) in GUTB patients after the end of treatment. Methods: This retrospective study was conducted at a tertiary hospital in South Korea. Data from patients (>18 years of age) with GUTB were collected from January 2005 to July 2016. CKD was defined as a glomerular filtration rate <60 mL/min/1.73m 2 after the end of treatment. Results: In total, 56 patients with GUTB (46.4{\%} males; mean age 52.8 ± 16.6 years) were enrolled in the study. CKD developed in 11 (19.6{\%}) patients and end-stage renal disease in 4 (7.1{\%}). In a univariate analysis, older age (p = 0.029), microscopic haematuria (p = 0.019), proteinuria (p = 0.029), acute renal failure (ARF) (p < 0.001) and a positive polymerase chain reaction-based test result for TB in the urine (p = 0.030) were significantly associated with decreased renal function. In a multivariate analysis, ARF (odds ratio [OR], 54.31; 95{\%} confidence interval [CI], 1.52-1944.00; p = 0.032) and old age (OR, 54.26; 95{\%} CI, 1.52-1932.94; p = 0.028) were independent risk factors for CKD in GUTB patients. Conclusions: ARF and old age were independent risk factors for CKD in GUTB patients. Therefore, in elderly GUTB patients with ARF at the time of diagnosis, regular follow-up of renal function should be performed even after the end of treatment.",
author = "Kim, {Eun Jin} and Woonji Lee and Jeong, {Woo Yong} and Hen Choi and Jung, {In Young} and Ahn, {Jin Young} and Jeong, {Su Jin} and Ku, {Nam Su} and Choi, {Jun Yong} and Choi, {Young Hwa} and Song, {Young Goo} and Kim, {June Myung}",
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Kim, EJ, Lee, W, Jeong, WY, Choi, H, Jung, IY, Ahn, JY, Jeong, SJ, Ku, NS, Choi, JY, Choi, YH, Song, YG & Kim, JM 2018, 'Chronic kidney disease with genitourinary tuberculosis: Old disease but ongoing complication', BMC Nephrology, vol. 19, no. 1, 193. https://doi.org/10.1186/s12882-018-0994-2

Chronic kidney disease with genitourinary tuberculosis : Old disease but ongoing complication. / Kim, Eun Jin; Lee, Woonji; Jeong, Woo Yong; Choi, Hen; Jung, In Young; Ahn, Jin Young; Jeong, Su Jin; Ku, Nam Su; Choi, Jun Yong; Choi, Young Hwa; Song, Young Goo; Kim, June Myung.

In: BMC Nephrology, Vol. 19, No. 1, 193, 02.08.2018.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Chronic kidney disease with genitourinary tuberculosis

T2 - Old disease but ongoing complication

AU - Kim, Eun Jin

AU - Lee, Woonji

AU - Jeong, Woo Yong

AU - Choi, Hen

AU - Jung, In Young

AU - Ahn, Jin Young

AU - Jeong, Su Jin

AU - Ku, Nam Su

AU - Choi, Jun Yong

AU - Choi, Young Hwa

AU - Song, Young Goo

AU - Kim, June Myung

PY - 2018/8/2

Y1 - 2018/8/2

N2 - Background: Genitourinary tuberculosis (GUTB) is a type of extrapulmonary TB that exerts a deleterious effect on renal function by promoting renal calcification and ureteric stricture. Therefore, we investigated the risk factors for chronic kidney disease (CKD) in GUTB patients after the end of treatment. Methods: This retrospective study was conducted at a tertiary hospital in South Korea. Data from patients (>18 years of age) with GUTB were collected from January 2005 to July 2016. CKD was defined as a glomerular filtration rate <60 mL/min/1.73m 2 after the end of treatment. Results: In total, 56 patients with GUTB (46.4% males; mean age 52.8 ± 16.6 years) were enrolled in the study. CKD developed in 11 (19.6%) patients and end-stage renal disease in 4 (7.1%). In a univariate analysis, older age (p = 0.029), microscopic haematuria (p = 0.019), proteinuria (p = 0.029), acute renal failure (ARF) (p < 0.001) and a positive polymerase chain reaction-based test result for TB in the urine (p = 0.030) were significantly associated with decreased renal function. In a multivariate analysis, ARF (odds ratio [OR], 54.31; 95% confidence interval [CI], 1.52-1944.00; p = 0.032) and old age (OR, 54.26; 95% CI, 1.52-1932.94; p = 0.028) were independent risk factors for CKD in GUTB patients. Conclusions: ARF and old age were independent risk factors for CKD in GUTB patients. Therefore, in elderly GUTB patients with ARF at the time of diagnosis, regular follow-up of renal function should be performed even after the end of treatment.

AB - Background: Genitourinary tuberculosis (GUTB) is a type of extrapulmonary TB that exerts a deleterious effect on renal function by promoting renal calcification and ureteric stricture. Therefore, we investigated the risk factors for chronic kidney disease (CKD) in GUTB patients after the end of treatment. Methods: This retrospective study was conducted at a tertiary hospital in South Korea. Data from patients (>18 years of age) with GUTB were collected from January 2005 to July 2016. CKD was defined as a glomerular filtration rate <60 mL/min/1.73m 2 after the end of treatment. Results: In total, 56 patients with GUTB (46.4% males; mean age 52.8 ± 16.6 years) were enrolled in the study. CKD developed in 11 (19.6%) patients and end-stage renal disease in 4 (7.1%). In a univariate analysis, older age (p = 0.029), microscopic haematuria (p = 0.019), proteinuria (p = 0.029), acute renal failure (ARF) (p < 0.001) and a positive polymerase chain reaction-based test result for TB in the urine (p = 0.030) were significantly associated with decreased renal function. In a multivariate analysis, ARF (odds ratio [OR], 54.31; 95% confidence interval [CI], 1.52-1944.00; p = 0.032) and old age (OR, 54.26; 95% CI, 1.52-1932.94; p = 0.028) were independent risk factors for CKD in GUTB patients. Conclusions: ARF and old age were independent risk factors for CKD in GUTB patients. Therefore, in elderly GUTB patients with ARF at the time of diagnosis, regular follow-up of renal function should be performed even after the end of treatment.

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U2 - 10.1186/s12882-018-0994-2

DO - 10.1186/s12882-018-0994-2

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