Chronic total occlusion intervention of the non-infarct-related artery in acute myocardial infarction patients: The Korean multicenter chronic total occlusion registry

Ji Young Park, Byoung Geol Choi, Seung Woon Rha, Tae Soo Kang, Cheol Ung Choi, Cheol Woong Yu, Hyeon Cheol Gwon, In Ho Chae, Hyo Soo Kim, Hun Sik Park, Seunghwan Lee, Moo Hyun Kim, Seung Ho Hur, Yangsoo Jang

Research output: Contribution to journalArticle

Abstract

Background The Korean chronic total occlusion (CTO) registry was collected prospectively from 26 cardiovascular centers since May 2007. The aim of this study is to investigate the impact of a successful staged percutaneous coronary intervention (PCI) of CTO lesions in acute myocardial infarction (AMI) patients on clinical outcomes. Patients and methods Among 2813 patients who underwent a staged PCI because of CTO lesions, 422 (15%) patients underwent primary PCI because of AMI. Among 422 patients, successful staged CTO-PCI was performed in 76%. The clinical outcomes were compared between the successful CTO-PCI group (n=321) and the failed CTO-PCI group (n=101). To adjust for potential confounders, a propensity score matching (PSM) analysis was carried out using the logistic regression model. Results After the PSM analysis, two propensity-matched groups (85 pairs, n=170) were generated and the baseline characteristics were balanced. The incidence of total death (P=0.029) and non-ST-segment elevation myocardial infarction (NSTEMI, P=0.043) at 1 year was higher in the failed CTO-PCI group. Multivariate regression showed that successful CTO-PCI was an independent predictor of preventing mortality (hazard ratio, 0.21, P=0.048). In the subgroup analysis, the Kaplan-Meier curve showed that successful CTO-PCI had a lower incidence of total death (log-rank=0.004) and cardiac death (log-rank=0.005) up to 1 year in NSTEMI patients. Cox-proportional analysis showed that successful CTO-PCI was beneficial in patients with NSTEMI, hypertension, and non-left-Anterior descending artery lesion for preventing mortality. Conclusion In this study, a staged successful CTO-PCI in AMI patients was associated with improved 1-year survival in the Korean population.

Original languageEnglish
Pages (from-to)495-501
Number of pages7
JournalCoronary Artery Disease
Volume29
Issue number6
DOIs
Publication statusPublished - 2018 Sep 1

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Percutaneous Coronary Intervention
Registries
Arteries
Myocardial Infarction
Propensity Score
Logistic Models
Mortality
Incidence
Research Design
Hypertension
Survival
Non-ST Elevated Myocardial Infarction

All Science Journal Classification (ASJC) codes

  • Cardiology and Cardiovascular Medicine

Cite this

Park, Ji Young ; Choi, Byoung Geol ; Rha, Seung Woon ; Kang, Tae Soo ; Choi, Cheol Ung ; Yu, Cheol Woong ; Gwon, Hyeon Cheol ; Chae, In Ho ; Kim, Hyo Soo ; Park, Hun Sik ; Lee, Seunghwan ; Kim, Moo Hyun ; Hur, Seung Ho ; Jang, Yangsoo. / Chronic total occlusion intervention of the non-infarct-related artery in acute myocardial infarction patients : The Korean multicenter chronic total occlusion registry. In: Coronary Artery Disease. 2018 ; Vol. 29, No. 6. pp. 495-501.
@article{5b92593e2e6844fba89245dc22b2295b,
title = "Chronic total occlusion intervention of the non-infarct-related artery in acute myocardial infarction patients: The Korean multicenter chronic total occlusion registry",
abstract = "Background The Korean chronic total occlusion (CTO) registry was collected prospectively from 26 cardiovascular centers since May 2007. The aim of this study is to investigate the impact of a successful staged percutaneous coronary intervention (PCI) of CTO lesions in acute myocardial infarction (AMI) patients on clinical outcomes. Patients and methods Among 2813 patients who underwent a staged PCI because of CTO lesions, 422 (15{\%}) patients underwent primary PCI because of AMI. Among 422 patients, successful staged CTO-PCI was performed in 76{\%}. The clinical outcomes were compared between the successful CTO-PCI group (n=321) and the failed CTO-PCI group (n=101). To adjust for potential confounders, a propensity score matching (PSM) analysis was carried out using the logistic regression model. Results After the PSM analysis, two propensity-matched groups (85 pairs, n=170) were generated and the baseline characteristics were balanced. The incidence of total death (P=0.029) and non-ST-segment elevation myocardial infarction (NSTEMI, P=0.043) at 1 year was higher in the failed CTO-PCI group. Multivariate regression showed that successful CTO-PCI was an independent predictor of preventing mortality (hazard ratio, 0.21, P=0.048). In the subgroup analysis, the Kaplan-Meier curve showed that successful CTO-PCI had a lower incidence of total death (log-rank=0.004) and cardiac death (log-rank=0.005) up to 1 year in NSTEMI patients. Cox-proportional analysis showed that successful CTO-PCI was beneficial in patients with NSTEMI, hypertension, and non-left-Anterior descending artery lesion for preventing mortality. Conclusion In this study, a staged successful CTO-PCI in AMI patients was associated with improved 1-year survival in the Korean population.",
author = "Park, {Ji Young} and Choi, {Byoung Geol} and Rha, {Seung Woon} and Kang, {Tae Soo} and Choi, {Cheol Ung} and Yu, {Cheol Woong} and Gwon, {Hyeon Cheol} and Chae, {In Ho} and Kim, {Hyo Soo} and Park, {Hun Sik} and Seunghwan Lee and Kim, {Moo Hyun} and Hur, {Seung Ho} and Yangsoo Jang",
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Chronic total occlusion intervention of the non-infarct-related artery in acute myocardial infarction patients : The Korean multicenter chronic total occlusion registry. / Park, Ji Young; Choi, Byoung Geol; Rha, Seung Woon; Kang, Tae Soo; Choi, Cheol Ung; Yu, Cheol Woong; Gwon, Hyeon Cheol; Chae, In Ho; Kim, Hyo Soo; Park, Hun Sik; Lee, Seunghwan; Kim, Moo Hyun; Hur, Seung Ho; Jang, Yangsoo.

In: Coronary Artery Disease, Vol. 29, No. 6, 01.09.2018, p. 495-501.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Chronic total occlusion intervention of the non-infarct-related artery in acute myocardial infarction patients

T2 - The Korean multicenter chronic total occlusion registry

AU - Park, Ji Young

AU - Choi, Byoung Geol

AU - Rha, Seung Woon

AU - Kang, Tae Soo

AU - Choi, Cheol Ung

AU - Yu, Cheol Woong

AU - Gwon, Hyeon Cheol

AU - Chae, In Ho

AU - Kim, Hyo Soo

AU - Park, Hun Sik

AU - Lee, Seunghwan

AU - Kim, Moo Hyun

AU - Hur, Seung Ho

AU - Jang, Yangsoo

PY - 2018/9/1

Y1 - 2018/9/1

N2 - Background The Korean chronic total occlusion (CTO) registry was collected prospectively from 26 cardiovascular centers since May 2007. The aim of this study is to investigate the impact of a successful staged percutaneous coronary intervention (PCI) of CTO lesions in acute myocardial infarction (AMI) patients on clinical outcomes. Patients and methods Among 2813 patients who underwent a staged PCI because of CTO lesions, 422 (15%) patients underwent primary PCI because of AMI. Among 422 patients, successful staged CTO-PCI was performed in 76%. The clinical outcomes were compared between the successful CTO-PCI group (n=321) and the failed CTO-PCI group (n=101). To adjust for potential confounders, a propensity score matching (PSM) analysis was carried out using the logistic regression model. Results After the PSM analysis, two propensity-matched groups (85 pairs, n=170) were generated and the baseline characteristics were balanced. The incidence of total death (P=0.029) and non-ST-segment elevation myocardial infarction (NSTEMI, P=0.043) at 1 year was higher in the failed CTO-PCI group. Multivariate regression showed that successful CTO-PCI was an independent predictor of preventing mortality (hazard ratio, 0.21, P=0.048). In the subgroup analysis, the Kaplan-Meier curve showed that successful CTO-PCI had a lower incidence of total death (log-rank=0.004) and cardiac death (log-rank=0.005) up to 1 year in NSTEMI patients. Cox-proportional analysis showed that successful CTO-PCI was beneficial in patients with NSTEMI, hypertension, and non-left-Anterior descending artery lesion for preventing mortality. Conclusion In this study, a staged successful CTO-PCI in AMI patients was associated with improved 1-year survival in the Korean population.

AB - Background The Korean chronic total occlusion (CTO) registry was collected prospectively from 26 cardiovascular centers since May 2007. The aim of this study is to investigate the impact of a successful staged percutaneous coronary intervention (PCI) of CTO lesions in acute myocardial infarction (AMI) patients on clinical outcomes. Patients and methods Among 2813 patients who underwent a staged PCI because of CTO lesions, 422 (15%) patients underwent primary PCI because of AMI. Among 422 patients, successful staged CTO-PCI was performed in 76%. The clinical outcomes were compared between the successful CTO-PCI group (n=321) and the failed CTO-PCI group (n=101). To adjust for potential confounders, a propensity score matching (PSM) analysis was carried out using the logistic regression model. Results After the PSM analysis, two propensity-matched groups (85 pairs, n=170) were generated and the baseline characteristics were balanced. The incidence of total death (P=0.029) and non-ST-segment elevation myocardial infarction (NSTEMI, P=0.043) at 1 year was higher in the failed CTO-PCI group. Multivariate regression showed that successful CTO-PCI was an independent predictor of preventing mortality (hazard ratio, 0.21, P=0.048). In the subgroup analysis, the Kaplan-Meier curve showed that successful CTO-PCI had a lower incidence of total death (log-rank=0.004) and cardiac death (log-rank=0.005) up to 1 year in NSTEMI patients. Cox-proportional analysis showed that successful CTO-PCI was beneficial in patients with NSTEMI, hypertension, and non-left-Anterior descending artery lesion for preventing mortality. Conclusion In this study, a staged successful CTO-PCI in AMI patients was associated with improved 1-year survival in the Korean population.

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U2 - 10.1097/MCA.0000000000000630

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