Chronological Change of Right Ventricle by Chronic Intermittent Hypoxia in Mice

Hyung Ju Cho, Woon Heo, Jung Woo Han, Yong Hyuk Lee, Jin Myung Park, Min Jung Kang, Joo Heon Yoon, Min Goo Lee, Chang Hoon Kim, Joo Young Kim

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Study Objective: No studies have investigated sequential changes in the heart on magnetic resonance imaging (MRI), along with observation of functional lung phenotypes and genetics, over the duration of chronic intermittent hypoxia (CIH). We investigated chronological changes in heart and lung phenotypes after CIH using a mouse model to provide new insights into the pathophysiology of sleep apnea-induced cardiovascular disease.

Methods: C57BL/6J adult male mice were randomized to 4 or 8 weeks of CIH. Cardiac cine-MRI images were analyzed to assess functional parameters of right ventricle (RV). Histopathological features of myocytes and pulmonary vessels, as well as genes involved in the endothelin (ET) system, were investigated.

Results: Function of the RV reduced significantly at 4 weeks and continuously decreased following another 4 weeks of CIH, although the rate of decrease was attenuated. Notably, persistence of reduced ejection fraction and end-systole RV wall thickness (WT) and increases in the ET system of the lungs and blood strongly implied the development of pulmonary hypertension after 8 weeks of CIH.

Conclusions: RV dysfunction with reduced end-systole RV WT could be a late phenotype in long-standing CIH and possibly also in obstructive sleep apnea.

Original languageEnglish
JournalSleep
Volume40
Issue number8
DOIs
Publication statusPublished - 2017 Aug 1

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Heart Ventricles
Lung
Systole
Endothelins
Phenotype
Cine Magnetic Resonance Imaging
Sleep Apnea Syndromes
Obstructive Sleep Apnea
Pulmonary Hypertension
Muscle Cells
Hypoxia
Cardiovascular Diseases
Magnetic Resonance Imaging
Observation
Genes

All Science Journal Classification (ASJC) codes

  • Clinical Neurology
  • Physiology (medical)

Cite this

Cho, H. J., Heo, W., Han, J. W., Lee, Y. H., Park, J. M., Kang, M. J., ... Kim, J. Y. (2017). Chronological Change of Right Ventricle by Chronic Intermittent Hypoxia in Mice. Sleep, 40(8). https://doi.org/10.1093/sleep/zsx103
Cho, Hyung Ju ; Heo, Woon ; Han, Jung Woo ; Lee, Yong Hyuk ; Park, Jin Myung ; Kang, Min Jung ; Yoon, Joo Heon ; Lee, Min Goo ; Kim, Chang Hoon ; Kim, Joo Young. / Chronological Change of Right Ventricle by Chronic Intermittent Hypoxia in Mice. In: Sleep. 2017 ; Vol. 40, No. 8.
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abstract = "Study Objective: No studies have investigated sequential changes in the heart on magnetic resonance imaging (MRI), along with observation of functional lung phenotypes and genetics, over the duration of chronic intermittent hypoxia (CIH). We investigated chronological changes in heart and lung phenotypes after CIH using a mouse model to provide new insights into the pathophysiology of sleep apnea-induced cardiovascular disease.Methods: C57BL/6J adult male mice were randomized to 4 or 8 weeks of CIH. Cardiac cine-MRI images were analyzed to assess functional parameters of right ventricle (RV). Histopathological features of myocytes and pulmonary vessels, as well as genes involved in the endothelin (ET) system, were investigated.Results: Function of the RV reduced significantly at 4 weeks and continuously decreased following another 4 weeks of CIH, although the rate of decrease was attenuated. Notably, persistence of reduced ejection fraction and end-systole RV wall thickness (WT) and increases in the ET system of the lungs and blood strongly implied the development of pulmonary hypertension after 8 weeks of CIH.Conclusions: RV dysfunction with reduced end-systole RV WT could be a late phenotype in long-standing CIH and possibly also in obstructive sleep apnea.",
author = "Cho, {Hyung Ju} and Woon Heo and Han, {Jung Woo} and Lee, {Yong Hyuk} and Park, {Jin Myung} and Kang, {Min Jung} and Yoon, {Joo Heon} and Lee, {Min Goo} and Kim, {Chang Hoon} and Kim, {Joo Young}",
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Cho, HJ, Heo, W, Han, JW, Lee, YH, Park, JM, Kang, MJ, Yoon, JH, Lee, MG, Kim, CH & Kim, JY 2017, 'Chronological Change of Right Ventricle by Chronic Intermittent Hypoxia in Mice', Sleep, vol. 40, no. 8. https://doi.org/10.1093/sleep/zsx103

Chronological Change of Right Ventricle by Chronic Intermittent Hypoxia in Mice. / Cho, Hyung Ju; Heo, Woon; Han, Jung Woo; Lee, Yong Hyuk; Park, Jin Myung; Kang, Min Jung; Yoon, Joo Heon; Lee, Min Goo; Kim, Chang Hoon; Kim, Joo Young.

In: Sleep, Vol. 40, No. 8, 01.08.2017.

Research output: Contribution to journalArticle

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AU - Han, Jung Woo

AU - Lee, Yong Hyuk

AU - Park, Jin Myung

AU - Kang, Min Jung

AU - Yoon, Joo Heon

AU - Lee, Min Goo

AU - Kim, Chang Hoon

AU - Kim, Joo Young

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Y1 - 2017/8/1

N2 - Study Objective: No studies have investigated sequential changes in the heart on magnetic resonance imaging (MRI), along with observation of functional lung phenotypes and genetics, over the duration of chronic intermittent hypoxia (CIH). We investigated chronological changes in heart and lung phenotypes after CIH using a mouse model to provide new insights into the pathophysiology of sleep apnea-induced cardiovascular disease.Methods: C57BL/6J adult male mice were randomized to 4 or 8 weeks of CIH. Cardiac cine-MRI images were analyzed to assess functional parameters of right ventricle (RV). Histopathological features of myocytes and pulmonary vessels, as well as genes involved in the endothelin (ET) system, were investigated.Results: Function of the RV reduced significantly at 4 weeks and continuously decreased following another 4 weeks of CIH, although the rate of decrease was attenuated. Notably, persistence of reduced ejection fraction and end-systole RV wall thickness (WT) and increases in the ET system of the lungs and blood strongly implied the development of pulmonary hypertension after 8 weeks of CIH.Conclusions: RV dysfunction with reduced end-systole RV WT could be a late phenotype in long-standing CIH and possibly also in obstructive sleep apnea.

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