Chronological changes in the systemic manifestations of intestinal Behcet's disease and their significance in diagnosis

Sung Jae Shin, Sang Kil Lee, Tae Il Kim, Jae Hee Cheon, Eun Soo Kim, Byung Chang Kim, Sooyoung Park, Won Ho Kim

Research output: Contribution to journalArticle

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Abstract

Purpose: Intestinal Behçet's disease (BD) is challenging to diagnose, especially if the patient presents with typical colonoscopic findings of intestinal BD without systemic manifestations of BD. We performed this study to evaluate the systemic manifestations of BD in patients with typical colonoscopic findings of intestinal BD at the time of initial presentation and to identity the chronologic changes of these features during an extended follow-up period. Methods: One hundred twenty-six consecutive patients who showed typical colonoscopic findings of intestinal BD at a single institution in Korea were enrolled. Clinical and endoscopic data were collected from a medical database and using a written questionnaire. Parameters including demographic characteristics and the subset type of BD at the initial and endpoints of the follow-up were analyzed. Results: The mean follow-up period was 63.9∈±∈50.9 months. The number of cases that satisfied the International Study Group for Behçet's Disease criteria at initial diagnosis, 19.0%, increased to 53.2% by the end of follow-up. When the Japanese criteria were used for classification, the proportion of complete and incomplete type BD increased (2.4% and 26.2% to 18.3% and 49.2%, respectively), while that of suspected and not-satisfied subtype BD decreased (22.2% and 49.2% to 19.0% and 13.5%, respectively) during the follow-up period. Conclusions: Our data suggest that patients who lack the systemic manifestations of BD could be included in the category of intestinal BD when typical intestinal lesion is identified, indicating that close examination and early treatment should be considered in such patients.

Original languageEnglish
Pages (from-to)1371-1376
Number of pages6
JournalInternational Journal of Colorectal Disease
Volume25
Issue number11
DOIs
Publication statusPublished - 2010 Nov 1

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Intestinal Diseases
Behcet Syndrome
Korea
Demography
Databases

All Science Journal Classification (ASJC) codes

  • Gastroenterology

Cite this

Shin, Sung Jae ; Lee, Sang Kil ; Kim, Tae Il ; Cheon, Jae Hee ; Kim, Eun Soo ; Kim, Byung Chang ; Park, Sooyoung ; Kim, Won Ho. / Chronological changes in the systemic manifestations of intestinal Behcet's disease and their significance in diagnosis. In: International Journal of Colorectal Disease. 2010 ; Vol. 25, No. 11. pp. 1371-1376.
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abstract = "Purpose: Intestinal Beh{\cc}et's disease (BD) is challenging to diagnose, especially if the patient presents with typical colonoscopic findings of intestinal BD without systemic manifestations of BD. We performed this study to evaluate the systemic manifestations of BD in patients with typical colonoscopic findings of intestinal BD at the time of initial presentation and to identity the chronologic changes of these features during an extended follow-up period. Methods: One hundred twenty-six consecutive patients who showed typical colonoscopic findings of intestinal BD at a single institution in Korea were enrolled. Clinical and endoscopic data were collected from a medical database and using a written questionnaire. Parameters including demographic characteristics and the subset type of BD at the initial and endpoints of the follow-up were analyzed. Results: The mean follow-up period was 63.9∈±∈50.9 months. The number of cases that satisfied the International Study Group for Beh{\cc}et's Disease criteria at initial diagnosis, 19.0{\%}, increased to 53.2{\%} by the end of follow-up. When the Japanese criteria were used for classification, the proportion of complete and incomplete type BD increased (2.4{\%} and 26.2{\%} to 18.3{\%} and 49.2{\%}, respectively), while that of suspected and not-satisfied subtype BD decreased (22.2{\%} and 49.2{\%} to 19.0{\%} and 13.5{\%}, respectively) during the follow-up period. Conclusions: Our data suggest that patients who lack the systemic manifestations of BD could be included in the category of intestinal BD when typical intestinal lesion is identified, indicating that close examination and early treatment should be considered in such patients.",
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Chronological changes in the systemic manifestations of intestinal Behcet's disease and their significance in diagnosis. / Shin, Sung Jae; Lee, Sang Kil; Kim, Tae Il; Cheon, Jae Hee; Kim, Eun Soo; Kim, Byung Chang; Park, Sooyoung; Kim, Won Ho.

In: International Journal of Colorectal Disease, Vol. 25, No. 11, 01.11.2010, p. 1371-1376.

Research output: Contribution to journalArticle

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AU - Shin, Sung Jae

AU - Lee, Sang Kil

AU - Kim, Tae Il

AU - Cheon, Jae Hee

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AU - Kim, Byung Chang

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AU - Kim, Won Ho

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N2 - Purpose: Intestinal Behçet's disease (BD) is challenging to diagnose, especially if the patient presents with typical colonoscopic findings of intestinal BD without systemic manifestations of BD. We performed this study to evaluate the systemic manifestations of BD in patients with typical colonoscopic findings of intestinal BD at the time of initial presentation and to identity the chronologic changes of these features during an extended follow-up period. Methods: One hundred twenty-six consecutive patients who showed typical colonoscopic findings of intestinal BD at a single institution in Korea were enrolled. Clinical and endoscopic data were collected from a medical database and using a written questionnaire. Parameters including demographic characteristics and the subset type of BD at the initial and endpoints of the follow-up were analyzed. Results: The mean follow-up period was 63.9∈±∈50.9 months. The number of cases that satisfied the International Study Group for Behçet's Disease criteria at initial diagnosis, 19.0%, increased to 53.2% by the end of follow-up. When the Japanese criteria were used for classification, the proportion of complete and incomplete type BD increased (2.4% and 26.2% to 18.3% and 49.2%, respectively), while that of suspected and not-satisfied subtype BD decreased (22.2% and 49.2% to 19.0% and 13.5%, respectively) during the follow-up period. Conclusions: Our data suggest that patients who lack the systemic manifestations of BD could be included in the category of intestinal BD when typical intestinal lesion is identified, indicating that close examination and early treatment should be considered in such patients.

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