Circadian and seasonal variations of ventricular tachyarrhythmias in patients with early repolarization syndrome and brugada syndrome: Analysis of patients with implantable cardioverter defibrillator

Jun Kim, Sung Hwan Kim, Gi Byoung Nam, Seunghee Baek, Hyung Oh Choi, Ki Hun Kim, Kee Joon Choi, Boyoung Joung, Hui Nam Pak, Moon Hyoung Lee, Sung Soon Kim, Seung Jung Park, Young Keun On, June Soo Kim, Il Young Oh, Eue Keun Choi, Seil Oh, Yun Shik Choi, Jong Il Choi, Sang Weon ParkYoung Hoon Kim, Man Young Lee, Hong Euy Lim, Young Soo Lee, Yongkeun Cho, Dong Il Lee, Dae Kyoung Cho, You Ho Kim

Research output: Contribution to journalArticle

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Abstract

Circadian and Seasonal Variation in Early Repolarization Syndrome. Introduction: The circadian and seasonal patterns of ventricular tachyarrhythmia (VTA) in patients with early repolarization syndrome (ERS) have not been determined. We compared the timing of VTAs in patients with ERS and Brugada syndrome (BS). Methods and Results: We enrolled patients with ERS (n = 14) and BS (n = 53) who underwent implantable cardioverter defibrillator (ICD) implantation. The timing of VTAs, including cardiac arrest and appropriate shocks, was determined. During follow up of 6.4 ± 3.6 years in the ERS group and 5.0 ± 3.3 years in the BS group, 5 of 14 (36%) ERS and 10 of 53 (19%) BS patients experienced appropriate shocks (P = 0.37). Cardiac arrest showed a trend of nocturnal distribution peaking from midnight to early morning (P = 0.14 in ERS, P = 0.16 in BS). Circadian distribution of appropriate shocks showed a significant nocturnal peak in patients with ERS (P < 0.0001) but a trend toward a nocturnal peak in patients with BS (P = 0.08). There were no seasonal differences in cardiac arrest in patients with ERS and BS. However, patients with ERS showed a seasonal peak in appropriate shocks from spring to summer (P < 0.0001). There was no significant seasonal peak in patients with BS. The timing of VTAs (cardiac arrest plus appropriate shock) showed significant nocturnal distributions in patients with ERS and BS (P < 0.01, respectively). A significant clustering of VTAs was noted from spring to summer (P < 0.01) in patients with ERS, but not in patients with BS (P = 0.42). Conclusions: Incidence of VTAs showed marked circadian variations with night-time peaks in patients with ERS and BS.

Original languageEnglish
Pages (from-to)757-763
Number of pages7
JournalJournal of Cardiovascular Electrophysiology
Volume23
Issue number7
DOIs
Publication statusPublished - 2012 Jul 1

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Brugada Syndrome
Implantable Defibrillators
Tachycardia
Shock
Heart Arrest

All Science Journal Classification (ASJC) codes

  • Cardiology and Cardiovascular Medicine
  • Physiology (medical)

Cite this

Kim, Jun ; Kim, Sung Hwan ; Nam, Gi Byoung ; Baek, Seunghee ; Choi, Hyung Oh ; Kim, Ki Hun ; Choi, Kee Joon ; Joung, Boyoung ; Pak, Hui Nam ; Lee, Moon Hyoung ; Kim, Sung Soon ; Park, Seung Jung ; On, Young Keun ; Kim, June Soo ; Oh, Il Young ; Choi, Eue Keun ; Oh, Seil ; Choi, Yun Shik ; Choi, Jong Il ; Park, Sang Weon ; Kim, Young Hoon ; Lee, Man Young ; Lim, Hong Euy ; Lee, Young Soo ; Cho, Yongkeun ; Lee, Dong Il ; Cho, Dae Kyoung ; Kim, You Ho. / Circadian and seasonal variations of ventricular tachyarrhythmias in patients with early repolarization syndrome and brugada syndrome : Analysis of patients with implantable cardioverter defibrillator. In: Journal of Cardiovascular Electrophysiology. 2012 ; Vol. 23, No. 7. pp. 757-763.
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title = "Circadian and seasonal variations of ventricular tachyarrhythmias in patients with early repolarization syndrome and brugada syndrome: Analysis of patients with implantable cardioverter defibrillator",
abstract = "Circadian and Seasonal Variation in Early Repolarization Syndrome. Introduction: The circadian and seasonal patterns of ventricular tachyarrhythmia (VTA) in patients with early repolarization syndrome (ERS) have not been determined. We compared the timing of VTAs in patients with ERS and Brugada syndrome (BS). Methods and Results: We enrolled patients with ERS (n = 14) and BS (n = 53) who underwent implantable cardioverter defibrillator (ICD) implantation. The timing of VTAs, including cardiac arrest and appropriate shocks, was determined. During follow up of 6.4 ± 3.6 years in the ERS group and 5.0 ± 3.3 years in the BS group, 5 of 14 (36{\%}) ERS and 10 of 53 (19{\%}) BS patients experienced appropriate shocks (P = 0.37). Cardiac arrest showed a trend of nocturnal distribution peaking from midnight to early morning (P = 0.14 in ERS, P = 0.16 in BS). Circadian distribution of appropriate shocks showed a significant nocturnal peak in patients with ERS (P < 0.0001) but a trend toward a nocturnal peak in patients with BS (P = 0.08). There were no seasonal differences in cardiac arrest in patients with ERS and BS. However, patients with ERS showed a seasonal peak in appropriate shocks from spring to summer (P < 0.0001). There was no significant seasonal peak in patients with BS. The timing of VTAs (cardiac arrest plus appropriate shock) showed significant nocturnal distributions in patients with ERS and BS (P < 0.01, respectively). A significant clustering of VTAs was noted from spring to summer (P < 0.01) in patients with ERS, but not in patients with BS (P = 0.42). Conclusions: Incidence of VTAs showed marked circadian variations with night-time peaks in patients with ERS and BS.",
author = "Jun Kim and Kim, {Sung Hwan} and Nam, {Gi Byoung} and Seunghee Baek and Choi, {Hyung Oh} and Kim, {Ki Hun} and Choi, {Kee Joon} and Boyoung Joung and Pak, {Hui Nam} and Lee, {Moon Hyoung} and Kim, {Sung Soon} and Park, {Seung Jung} and On, {Young Keun} and Kim, {June Soo} and Oh, {Il Young} and Choi, {Eue Keun} and Seil Oh and Choi, {Yun Shik} and Choi, {Jong Il} and Park, {Sang Weon} and Kim, {Young Hoon} and Lee, {Man Young} and Lim, {Hong Euy} and Lee, {Young Soo} and Yongkeun Cho and Lee, {Dong Il} and Cho, {Dae Kyoung} and Kim, {You Ho}",
year = "2012",
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doi = "10.1111/j.1540-8167.2011.02287.x",
language = "English",
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Kim, J, Kim, SH, Nam, GB, Baek, S, Choi, HO, Kim, KH, Choi, KJ, Joung, B, Pak, HN, Lee, MH, Kim, SS, Park, SJ, On, YK, Kim, JS, Oh, IY, Choi, EK, Oh, S, Choi, YS, Choi, JI, Park, SW, Kim, YH, Lee, MY, Lim, HE, Lee, YS, Cho, Y, Lee, DI, Cho, DK & Kim, YH 2012, 'Circadian and seasonal variations of ventricular tachyarrhythmias in patients with early repolarization syndrome and brugada syndrome: Analysis of patients with implantable cardioverter defibrillator', Journal of Cardiovascular Electrophysiology, vol. 23, no. 7, pp. 757-763. https://doi.org/10.1111/j.1540-8167.2011.02287.x

Circadian and seasonal variations of ventricular tachyarrhythmias in patients with early repolarization syndrome and brugada syndrome : Analysis of patients with implantable cardioverter defibrillator. / Kim, Jun; Kim, Sung Hwan; Nam, Gi Byoung; Baek, Seunghee; Choi, Hyung Oh; Kim, Ki Hun; Choi, Kee Joon; Joung, Boyoung; Pak, Hui Nam; Lee, Moon Hyoung; Kim, Sung Soon; Park, Seung Jung; On, Young Keun; Kim, June Soo; Oh, Il Young; Choi, Eue Keun; Oh, Seil; Choi, Yun Shik; Choi, Jong Il; Park, Sang Weon; Kim, Young Hoon; Lee, Man Young; Lim, Hong Euy; Lee, Young Soo; Cho, Yongkeun; Lee, Dong Il; Cho, Dae Kyoung; Kim, You Ho.

In: Journal of Cardiovascular Electrophysiology, Vol. 23, No. 7, 01.07.2012, p. 757-763.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Circadian and seasonal variations of ventricular tachyarrhythmias in patients with early repolarization syndrome and brugada syndrome

T2 - Analysis of patients with implantable cardioverter defibrillator

AU - Kim, Jun

AU - Kim, Sung Hwan

AU - Nam, Gi Byoung

AU - Baek, Seunghee

AU - Choi, Hyung Oh

AU - Kim, Ki Hun

AU - Choi, Kee Joon

AU - Joung, Boyoung

AU - Pak, Hui Nam

AU - Lee, Moon Hyoung

AU - Kim, Sung Soon

AU - Park, Seung Jung

AU - On, Young Keun

AU - Kim, June Soo

AU - Oh, Il Young

AU - Choi, Eue Keun

AU - Oh, Seil

AU - Choi, Yun Shik

AU - Choi, Jong Il

AU - Park, Sang Weon

AU - Kim, Young Hoon

AU - Lee, Man Young

AU - Lim, Hong Euy

AU - Lee, Young Soo

AU - Cho, Yongkeun

AU - Lee, Dong Il

AU - Cho, Dae Kyoung

AU - Kim, You Ho

PY - 2012/7/1

Y1 - 2012/7/1

N2 - Circadian and Seasonal Variation in Early Repolarization Syndrome. Introduction: The circadian and seasonal patterns of ventricular tachyarrhythmia (VTA) in patients with early repolarization syndrome (ERS) have not been determined. We compared the timing of VTAs in patients with ERS and Brugada syndrome (BS). Methods and Results: We enrolled patients with ERS (n = 14) and BS (n = 53) who underwent implantable cardioverter defibrillator (ICD) implantation. The timing of VTAs, including cardiac arrest and appropriate shocks, was determined. During follow up of 6.4 ± 3.6 years in the ERS group and 5.0 ± 3.3 years in the BS group, 5 of 14 (36%) ERS and 10 of 53 (19%) BS patients experienced appropriate shocks (P = 0.37). Cardiac arrest showed a trend of nocturnal distribution peaking from midnight to early morning (P = 0.14 in ERS, P = 0.16 in BS). Circadian distribution of appropriate shocks showed a significant nocturnal peak in patients with ERS (P < 0.0001) but a trend toward a nocturnal peak in patients with BS (P = 0.08). There were no seasonal differences in cardiac arrest in patients with ERS and BS. However, patients with ERS showed a seasonal peak in appropriate shocks from spring to summer (P < 0.0001). There was no significant seasonal peak in patients with BS. The timing of VTAs (cardiac arrest plus appropriate shock) showed significant nocturnal distributions in patients with ERS and BS (P < 0.01, respectively). A significant clustering of VTAs was noted from spring to summer (P < 0.01) in patients with ERS, but not in patients with BS (P = 0.42). Conclusions: Incidence of VTAs showed marked circadian variations with night-time peaks in patients with ERS and BS.

AB - Circadian and Seasonal Variation in Early Repolarization Syndrome. Introduction: The circadian and seasonal patterns of ventricular tachyarrhythmia (VTA) in patients with early repolarization syndrome (ERS) have not been determined. We compared the timing of VTAs in patients with ERS and Brugada syndrome (BS). Methods and Results: We enrolled patients with ERS (n = 14) and BS (n = 53) who underwent implantable cardioverter defibrillator (ICD) implantation. The timing of VTAs, including cardiac arrest and appropriate shocks, was determined. During follow up of 6.4 ± 3.6 years in the ERS group and 5.0 ± 3.3 years in the BS group, 5 of 14 (36%) ERS and 10 of 53 (19%) BS patients experienced appropriate shocks (P = 0.37). Cardiac arrest showed a trend of nocturnal distribution peaking from midnight to early morning (P = 0.14 in ERS, P = 0.16 in BS). Circadian distribution of appropriate shocks showed a significant nocturnal peak in patients with ERS (P < 0.0001) but a trend toward a nocturnal peak in patients with BS (P = 0.08). There were no seasonal differences in cardiac arrest in patients with ERS and BS. However, patients with ERS showed a seasonal peak in appropriate shocks from spring to summer (P < 0.0001). There was no significant seasonal peak in patients with BS. The timing of VTAs (cardiac arrest plus appropriate shock) showed significant nocturnal distributions in patients with ERS and BS (P < 0.01, respectively). A significant clustering of VTAs was noted from spring to summer (P < 0.01) in patients with ERS, but not in patients with BS (P = 0.42). Conclusions: Incidence of VTAs showed marked circadian variations with night-time peaks in patients with ERS and BS.

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