Circulating autoantibodies in patients with aspirin-intolerant asthma

An epiphenomenon related to airway inflammation

Young Min Ye, Dong Ho Nahm, Sangha Kim, Seung Hyun Kim, Jeong Hee Choi, Chang Hee Suh, Hae Sim Park

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Several studies have suggested the involvement of an autoimmune mechanism in aspirin (ASA)-intolerant asthma. To test this hypothesis, we measured the levels of circulating autoantibodies, such as IgG and IgA to tissue transglutaminase (TGase), IgG to cytokeratins (CKs) 8, 18, and 19, Clq-binding immune complex (CIC), and antinuclear antibody (ANA), in the sera of 79 patients with ASA-intolerant asthma (Group I) and those of two control groups, consisting of 61 patients with ASA-tolerant asthma (Group II) and 88 healthy control subjects (Group III) by means of ELISA. Significantly higher prevalences of IgG antibodies to CK18 (13.9%) and CK19 (17.7%) were noted in Group I, as compared with Group III (p<0.05 for all) not with Group II. Regarding the prevalences of other autoantibodies, the levels of ANA (1.3%), IgG to TGase (3.8%), and CIC (24.7%) in Group I were not significantly different from those in Groups II and III. Significant correlations were found between positivities for the anti-CK18 and anti-CK19 autoantibodies and the PC20 methacholine values in the analysis of asthma Groups I and II vs. normal controls, (p=0.001 and p=0.003, respectively). Further studies are needed to explore the potential involvement of an autoantibody-mediated mechanism in the clinical manifestation of bronchial asthma.

Original languageEnglish
Pages (from-to)412-417
Number of pages6
JournalJournal of Korean medical science
Volume21
Issue number3
DOIs
Publication statusPublished - 2006 Jan 1

Fingerprint

Autoantibodies
Aspirin
Asthma
Inflammation
Immunoglobulin G
Antinuclear Antibodies
Antigen-Antibody Complex
Keratin-8
Keratin-18
Keratin-19
Control Groups
Transglutaminases
Methacholine Chloride
Immunoglobulin A
Healthy Volunteers
Enzyme-Linked Immunosorbent Assay
Antibodies
Serum

All Science Journal Classification (ASJC) codes

  • Medicine(all)

Cite this

Ye, Young Min ; Nahm, Dong Ho ; Kim, Sangha ; Kim, Seung Hyun ; Choi, Jeong Hee ; Suh, Chang Hee ; Park, Hae Sim. / Circulating autoantibodies in patients with aspirin-intolerant asthma : An epiphenomenon related to airway inflammation. In: Journal of Korean medical science. 2006 ; Vol. 21, No. 3. pp. 412-417.
@article{4480fe76616b40158e581e948f98ba65,
title = "Circulating autoantibodies in patients with aspirin-intolerant asthma: An epiphenomenon related to airway inflammation",
abstract = "Several studies have suggested the involvement of an autoimmune mechanism in aspirin (ASA)-intolerant asthma. To test this hypothesis, we measured the levels of circulating autoantibodies, such as IgG and IgA to tissue transglutaminase (TGase), IgG to cytokeratins (CKs) 8, 18, and 19, Clq-binding immune complex (CIC), and antinuclear antibody (ANA), in the sera of 79 patients with ASA-intolerant asthma (Group I) and those of two control groups, consisting of 61 patients with ASA-tolerant asthma (Group II) and 88 healthy control subjects (Group III) by means of ELISA. Significantly higher prevalences of IgG antibodies to CK18 (13.9{\%}) and CK19 (17.7{\%}) were noted in Group I, as compared with Group III (p<0.05 for all) not with Group II. Regarding the prevalences of other autoantibodies, the levels of ANA (1.3{\%}), IgG to TGase (3.8{\%}), and CIC (24.7{\%}) in Group I were not significantly different from those in Groups II and III. Significant correlations were found between positivities for the anti-CK18 and anti-CK19 autoantibodies and the PC20 methacholine values in the analysis of asthma Groups I and II vs. normal controls, (p=0.001 and p=0.003, respectively). Further studies are needed to explore the potential involvement of an autoantibody-mediated mechanism in the clinical manifestation of bronchial asthma.",
author = "Ye, {Young Min} and Nahm, {Dong Ho} and Sangha Kim and Kim, {Seung Hyun} and Choi, {Jeong Hee} and Suh, {Chang Hee} and Park, {Hae Sim}",
year = "2006",
month = "1",
day = "1",
doi = "10.3346/jkms.2006.21.3.412",
language = "English",
volume = "21",
pages = "412--417",
journal = "Journal of Korean Medical Science",
issn = "1011-8934",
publisher = "Korean Academy of Medical Science",
number = "3",

}

Circulating autoantibodies in patients with aspirin-intolerant asthma : An epiphenomenon related to airway inflammation. / Ye, Young Min; Nahm, Dong Ho; Kim, Sangha; Kim, Seung Hyun; Choi, Jeong Hee; Suh, Chang Hee; Park, Hae Sim.

In: Journal of Korean medical science, Vol. 21, No. 3, 01.01.2006, p. 412-417.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Circulating autoantibodies in patients with aspirin-intolerant asthma

T2 - An epiphenomenon related to airway inflammation

AU - Ye, Young Min

AU - Nahm, Dong Ho

AU - Kim, Sangha

AU - Kim, Seung Hyun

AU - Choi, Jeong Hee

AU - Suh, Chang Hee

AU - Park, Hae Sim

PY - 2006/1/1

Y1 - 2006/1/1

N2 - Several studies have suggested the involvement of an autoimmune mechanism in aspirin (ASA)-intolerant asthma. To test this hypothesis, we measured the levels of circulating autoantibodies, such as IgG and IgA to tissue transglutaminase (TGase), IgG to cytokeratins (CKs) 8, 18, and 19, Clq-binding immune complex (CIC), and antinuclear antibody (ANA), in the sera of 79 patients with ASA-intolerant asthma (Group I) and those of two control groups, consisting of 61 patients with ASA-tolerant asthma (Group II) and 88 healthy control subjects (Group III) by means of ELISA. Significantly higher prevalences of IgG antibodies to CK18 (13.9%) and CK19 (17.7%) were noted in Group I, as compared with Group III (p<0.05 for all) not with Group II. Regarding the prevalences of other autoantibodies, the levels of ANA (1.3%), IgG to TGase (3.8%), and CIC (24.7%) in Group I were not significantly different from those in Groups II and III. Significant correlations were found between positivities for the anti-CK18 and anti-CK19 autoantibodies and the PC20 methacholine values in the analysis of asthma Groups I and II vs. normal controls, (p=0.001 and p=0.003, respectively). Further studies are needed to explore the potential involvement of an autoantibody-mediated mechanism in the clinical manifestation of bronchial asthma.

AB - Several studies have suggested the involvement of an autoimmune mechanism in aspirin (ASA)-intolerant asthma. To test this hypothesis, we measured the levels of circulating autoantibodies, such as IgG and IgA to tissue transglutaminase (TGase), IgG to cytokeratins (CKs) 8, 18, and 19, Clq-binding immune complex (CIC), and antinuclear antibody (ANA), in the sera of 79 patients with ASA-intolerant asthma (Group I) and those of two control groups, consisting of 61 patients with ASA-tolerant asthma (Group II) and 88 healthy control subjects (Group III) by means of ELISA. Significantly higher prevalences of IgG antibodies to CK18 (13.9%) and CK19 (17.7%) were noted in Group I, as compared with Group III (p<0.05 for all) not with Group II. Regarding the prevalences of other autoantibodies, the levels of ANA (1.3%), IgG to TGase (3.8%), and CIC (24.7%) in Group I were not significantly different from those in Groups II and III. Significant correlations were found between positivities for the anti-CK18 and anti-CK19 autoantibodies and the PC20 methacholine values in the analysis of asthma Groups I and II vs. normal controls, (p=0.001 and p=0.003, respectively). Further studies are needed to explore the potential involvement of an autoantibody-mediated mechanism in the clinical manifestation of bronchial asthma.

UR - http://www.scopus.com/inward/record.url?scp=33745247171&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=33745247171&partnerID=8YFLogxK

U2 - 10.3346/jkms.2006.21.3.412

DO - 10.3346/jkms.2006.21.3.412

M3 - Article

VL - 21

SP - 412

EP - 417

JO - Journal of Korean Medical Science

JF - Journal of Korean Medical Science

SN - 1011-8934

IS - 3

ER -