Circulating IL-8 levels in heart failure patients with and without metabolic syndrome

Min Jeong Shin, Kyung Hye Lee, Ji Hyung Chung, Yoo Kyoung Park, Mi Kyung Choi, Jaewon Oh, Ji Won Choi, Sang Hak Lee, Namsik Chung, Seok Min Kang

Research output: Contribution to journalArticlepeer-review

7 Citations (Scopus)

Abstract

Background: It has been suggested that the metabolic syndrome (MetS) is associated with increased risk for heart failure (HF) and progression of HF. However, the underlying mechanisms are unclear. We tested whether the presence of the MetS would be associated with the increased degree of inflammatory state in HF. Methods: Ninety-one eligible consecutive stable HF patients participated in this cross-sectional study. Anthropometric measurements were carried out and serum concentrations of lipoproteins, apolipoproteins (apoB, apoAI) and high sensitivity C-reactive protein (hsCRP) were measured. The simultaneous measurement of 17 cytokines using bioplex analysis was used. Result: Thirty-five subjects (39% of total, 48% of males and 31% of females) were classified as having the MetS in total HF patients. Serum concentrations of apoB (p < 0.005) were significantly higher and the ratio of apoAI and apoB was significantly lower (p < 0.01) in HF patients with MetS than those without MetS. Plasma levels of IL-8 (p < 0.05) were significantly higher in HF patients with MetS than those without MetS. In addition, serum concentrations of hsCRP (p < 0.005) were significantly higher in HF patients with MetS compared to those without MetS. Conclusions: The MetS in HF is associated with increased degree of inflammation, which provides information regarding the relationship between inflammation and HF with MetS.

Original languageEnglish
Pages (from-to)139-142
Number of pages4
JournalClinica Chimica Acta
Volume405
Issue number1-2
DOIs
Publication statusPublished - 2009 Jul

Bibliographical note

Funding Information:
This study was supported by a grant of the Korea Healthcare technology R&D Project, Ministry for Health, Welfare & Family Affairs, Republic of Korea (A080742) and the Korea Research Foundation Grant funded by the Korean Government (MOEHRD, Basic Research Promotion Fund) (KRF-2008-331-C00309).

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Clinical Biochemistry
  • Biochemistry, medical

Fingerprint Dive into the research topics of 'Circulating IL-8 levels in heart failure patients with and without metabolic syndrome'. Together they form a unique fingerprint.

Cite this