Circulating TNF receptors are significant prognostic biomarkers for idiopathic membranous nephropathy

Su Mi Lee, Seung Hee Yang, Ran Hui Cha, Myounghee Kim, Jung Nam An, Jin Ho Paik, Dong Ki Kim, Shin-Wook Kang, Chun Soo Lim, Yon Su Kim, Jung Pyo Lee

Research output: Contribution to journalArticle

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Abstract

Idiopathic membranous nephropathy (iMN) is a common cause of nephrotic syndrome in adults. A biomarker to accurately indicate the severity of iMN and predict long-term prognosis is insufficient. Here, we evaluated the clinical significance of circulating tumor necrosis factor receptors (cTNFRs) as prognostic biomarkers of iMN with nephrotic syndrome. A total of 113 patients with biopsy-proven iMN and 43 healthy volunteers were enrolled in this study. Ninety patients with iMN had nephrotic range proteinuria. Levels of cTNFRs were measured by using serum samples collected at the time of initial diagnosis. Levels of cTNFRs were higher in the patients with nephrotic syndrome than in those with subnephrotic range proteinuria or in the healthy volunteers (P for trend <0.001). Estimated glomerular filtration rate and proteinuria tended to worsen as the cTNFRs levels increased. Having a cTNFR1 level within the highest tertile was a significant risk factor for renal progression after adjustment, in comparison with the other tertiles (hazard ratio [HR], 3.39; 95% confidence interval [95% CI], 1.48-7.78; P = 0.004). The cTNFR2 level within the highest tertile also significantly increased the risk of renal progression (HR, 3.29; 95% CI, 1.43-7.54; P = 0.005). Renal tubular TNFRs expression was associated with cTNFRs level. However, the cTNFRs levels were not associated with autoantibody against phospholipase A2 receptor reactivity/levels or treatment response. This study demonstrated that cTNFRs levels at the time of initial diagnosis could predict renal progression in patients with iMN.

Original languageEnglish
Article numbere104354
JournalPloS one
Volume9
Issue number8
DOIs
Publication statusPublished - 2014 Aug 6

Fingerprint

Membranous Glomerulonephritis
Tumor Necrosis Factor Receptors
Biomarkers
kidney diseases
tumor necrosis factors
biomarkers
receptors
nephrotic syndrome
Nephrotic Syndrome
Proteinuria
Kidney
kidneys
Phospholipase A2 Receptors
Hazards
Healthy Volunteers
volunteers
confidence interval
Confidence Intervals
Biopsy
phospholipase A2

All Science Journal Classification (ASJC) codes

  • Biochemistry, Genetics and Molecular Biology(all)
  • Agricultural and Biological Sciences(all)

Cite this

Lee, S. M., Yang, S. H., Cha, R. H., Kim, M., An, J. N., Paik, J. H., ... Lee, J. P. (2014). Circulating TNF receptors are significant prognostic biomarkers for idiopathic membranous nephropathy. PloS one, 9(8), [e104354]. https://doi.org/10.1371/journal.pone.0104354
Lee, Su Mi ; Yang, Seung Hee ; Cha, Ran Hui ; Kim, Myounghee ; An, Jung Nam ; Paik, Jin Ho ; Kim, Dong Ki ; Kang, Shin-Wook ; Lim, Chun Soo ; Kim, Yon Su ; Lee, Jung Pyo. / Circulating TNF receptors are significant prognostic biomarkers for idiopathic membranous nephropathy. In: PloS one. 2014 ; Vol. 9, No. 8.
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abstract = "Idiopathic membranous nephropathy (iMN) is a common cause of nephrotic syndrome in adults. A biomarker to accurately indicate the severity of iMN and predict long-term prognosis is insufficient. Here, we evaluated the clinical significance of circulating tumor necrosis factor receptors (cTNFRs) as prognostic biomarkers of iMN with nephrotic syndrome. A total of 113 patients with biopsy-proven iMN and 43 healthy volunteers were enrolled in this study. Ninety patients with iMN had nephrotic range proteinuria. Levels of cTNFRs were measured by using serum samples collected at the time of initial diagnosis. Levels of cTNFRs were higher in the patients with nephrotic syndrome than in those with subnephrotic range proteinuria or in the healthy volunteers (P for trend <0.001). Estimated glomerular filtration rate and proteinuria tended to worsen as the cTNFRs levels increased. Having a cTNFR1 level within the highest tertile was a significant risk factor for renal progression after adjustment, in comparison with the other tertiles (hazard ratio [HR], 3.39; 95{\%} confidence interval [95{\%} CI], 1.48-7.78; P = 0.004). The cTNFR2 level within the highest tertile also significantly increased the risk of renal progression (HR, 3.29; 95{\%} CI, 1.43-7.54; P = 0.005). Renal tubular TNFRs expression was associated with cTNFRs level. However, the cTNFRs levels were not associated with autoantibody against phospholipase A2 receptor reactivity/levels or treatment response. This study demonstrated that cTNFRs levels at the time of initial diagnosis could predict renal progression in patients with iMN.",
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Lee, SM, Yang, SH, Cha, RH, Kim, M, An, JN, Paik, JH, Kim, DK, Kang, S-W, Lim, CS, Kim, YS & Lee, JP 2014, 'Circulating TNF receptors are significant prognostic biomarkers for idiopathic membranous nephropathy', PloS one, vol. 9, no. 8, e104354. https://doi.org/10.1371/journal.pone.0104354

Circulating TNF receptors are significant prognostic biomarkers for idiopathic membranous nephropathy. / Lee, Su Mi; Yang, Seung Hee; Cha, Ran Hui; Kim, Myounghee; An, Jung Nam; Paik, Jin Ho; Kim, Dong Ki; Kang, Shin-Wook; Lim, Chun Soo; Kim, Yon Su; Lee, Jung Pyo.

In: PloS one, Vol. 9, No. 8, e104354, 06.08.2014.

Research output: Contribution to journalArticle

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T1 - Circulating TNF receptors are significant prognostic biomarkers for idiopathic membranous nephropathy

AU - Lee, Su Mi

AU - Yang, Seung Hee

AU - Cha, Ran Hui

AU - Kim, Myounghee

AU - An, Jung Nam

AU - Paik, Jin Ho

AU - Kim, Dong Ki

AU - Kang, Shin-Wook

AU - Lim, Chun Soo

AU - Kim, Yon Su

AU - Lee, Jung Pyo

PY - 2014/8/6

Y1 - 2014/8/6

N2 - Idiopathic membranous nephropathy (iMN) is a common cause of nephrotic syndrome in adults. A biomarker to accurately indicate the severity of iMN and predict long-term prognosis is insufficient. Here, we evaluated the clinical significance of circulating tumor necrosis factor receptors (cTNFRs) as prognostic biomarkers of iMN with nephrotic syndrome. A total of 113 patients with biopsy-proven iMN and 43 healthy volunteers were enrolled in this study. Ninety patients with iMN had nephrotic range proteinuria. Levels of cTNFRs were measured by using serum samples collected at the time of initial diagnosis. Levels of cTNFRs were higher in the patients with nephrotic syndrome than in those with subnephrotic range proteinuria or in the healthy volunteers (P for trend <0.001). Estimated glomerular filtration rate and proteinuria tended to worsen as the cTNFRs levels increased. Having a cTNFR1 level within the highest tertile was a significant risk factor for renal progression after adjustment, in comparison with the other tertiles (hazard ratio [HR], 3.39; 95% confidence interval [95% CI], 1.48-7.78; P = 0.004). The cTNFR2 level within the highest tertile also significantly increased the risk of renal progression (HR, 3.29; 95% CI, 1.43-7.54; P = 0.005). Renal tubular TNFRs expression was associated with cTNFRs level. However, the cTNFRs levels were not associated with autoantibody against phospholipase A2 receptor reactivity/levels or treatment response. This study demonstrated that cTNFRs levels at the time of initial diagnosis could predict renal progression in patients with iMN.

AB - Idiopathic membranous nephropathy (iMN) is a common cause of nephrotic syndrome in adults. A biomarker to accurately indicate the severity of iMN and predict long-term prognosis is insufficient. Here, we evaluated the clinical significance of circulating tumor necrosis factor receptors (cTNFRs) as prognostic biomarkers of iMN with nephrotic syndrome. A total of 113 patients with biopsy-proven iMN and 43 healthy volunteers were enrolled in this study. Ninety patients with iMN had nephrotic range proteinuria. Levels of cTNFRs were measured by using serum samples collected at the time of initial diagnosis. Levels of cTNFRs were higher in the patients with nephrotic syndrome than in those with subnephrotic range proteinuria or in the healthy volunteers (P for trend <0.001). Estimated glomerular filtration rate and proteinuria tended to worsen as the cTNFRs levels increased. Having a cTNFR1 level within the highest tertile was a significant risk factor for renal progression after adjustment, in comparison with the other tertiles (hazard ratio [HR], 3.39; 95% confidence interval [95% CI], 1.48-7.78; P = 0.004). The cTNFR2 level within the highest tertile also significantly increased the risk of renal progression (HR, 3.29; 95% CI, 1.43-7.54; P = 0.005). Renal tubular TNFRs expression was associated with cTNFRs level. However, the cTNFRs levels were not associated with autoantibody against phospholipase A2 receptor reactivity/levels or treatment response. This study demonstrated that cTNFRs levels at the time of initial diagnosis could predict renal progression in patients with iMN.

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