Cl3CCONH2/PPh3 was a versatile reagent to convert carboxylic acids into their corresponding acid chlorides. This intermediate was clearly confirmed by spectroscopic methods (IR, 1H, 13C NMR). This one-pot reaction of in situ acid chloride generated with various alcohols successfully furnished the corresponding esters in moderate to excellent yields.
Bibliographical noteFunding Information:
Financial support from the Thailand Research Fund through the Royal Golden Jubilee Ph.D. Program (Grant No. PHD/0223/2548) to O. C. and W. C. is acknowledged. O. C. and W. C. are also indebted to the Graduate School, Chulalongkorn University, for a grant. One of us (D. O. J.) is also grateful for the support from Institute for NanoBio Molecular Assemblies.
All Science Journal Classification (ASJC) codes
- Organic Chemistry