Class III β-tubulin shows unique expression patterns in a variety of neoplastic and non-neoplastic lymphoproliferative disorders

Sun Och Yoon, Wook Youn Kim, Heounjeong Go, Jin Ho Paik, Ji Eun Kim, Young A. Kim, Joo R. Huh, Yoon Kyung Jeon, Chul Woo Kim

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

Class III β-tubulin (TUBB3) expression in carcinoma is associated with resistance to tubulin-binding chemotherapeutic agents. Recently, follicular dendritic cells (FDCs) were reported to express TUBB3 under physiologic conditions. We investigated TUBB3 expression in a wide range of lymphoproliferative disorders using immunohistochemistry. Dual immunostaining for Bcl-6 and TUBB3 revealed that some germinal center B cells also express TUBB3 in addition to FDCs. In Hodgkin lymphomas (HLs), 47.1% (40/85) expressed TUBB3 in the tumor cells with an all-or-none pattern. TUBB3 expression in HL was more common in mixed cellularity type than nodular sclerosis type (P=0.032). Among non-HLs, 79.3% (23/29) of anaplastic large cell lymphoma (ALCL), 8% (2/25) of extranodal natural killer/T-cell lymphoma, and 75% (21/28) of Burkitt lymphoma showed TUBB3 expression with an all-or-none pattern. Of diffuse large B-cell lymphoma, 15.2% (32/210) expressed TUBB3 in a heterogeneous pattern. In ALCL, TUBB3 expression was more common in systemic ALCL than in primary cutaneous ALCL (P=0.046). Diffuse large B-cell lymphomas with a germinal center B-like subgroup exhibited TUBB3 expression more frequently than non-GCB-like subgroup (P=0.01). Otherwise, none of the 18 angioimmunoblastic T-cell lymphomas; 18 peripheral T-cell lymphomas, not otherwise specified; 12 follicular lymphomas; 62 marginal zone lymphomas; 7 mantle cell lymphomas; 8 small lymphocytic lymphomas; or 2 FDC sarcomas expressed TUBB3. In angioimmunoblastic T-cell lymphoma and Castleman disease, TUBB3 was positive in immunoblasts corresponding to Epstein-Barr virus-infected or Kaposi sarcoma herpes virus-infected cells. A variety of neoplastic and non-neoplastic lymphoproliferative disorders exhibited characteristic TUBB3 expression patterns; these results suggest potential for diagnostic utility, some insight into the pathobiology of TUBB3 expression, and potential therapeutic implications.

Original languageEnglish
Pages (from-to)645-655
Number of pages11
JournalAmerican Journal of Surgical Pathology
Volume34
Issue number5
DOIs
Publication statusPublished - 2010 May

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Anaplastic Large-Cell Lymphoma
Lymphoproliferative Disorders
T-Cell Lymphoma
Tubulin
Follicular Dendritic Cells
Germinal Center
Lymphoma, Large B-Cell, Diffuse
Hodgkin Disease
Follicular Dendritic Cell Sarcoma
Primary Cutaneous Anaplastic Large Cell Lymphoma
Peripheral T-Cell Lymphoma
Giant Lymph Node Hyperplasia
Mantle-Cell Lymphoma
Follicular Lymphoma
Natural Killer T-Cells
Burkitt Lymphoma
Kaposi's Sarcoma
Sclerosis
B-Cell Chronic Lymphocytic Leukemia
Human Herpesvirus 4

All Science Journal Classification (ASJC) codes

  • Anatomy
  • Surgery
  • Pathology and Forensic Medicine

Cite this

Yoon, Sun Och ; Kim, Wook Youn ; Go, Heounjeong ; Paik, Jin Ho ; Kim, Ji Eun ; Kim, Young A. ; Huh, Joo R. ; Jeon, Yoon Kyung ; Kim, Chul Woo. / Class III β-tubulin shows unique expression patterns in a variety of neoplastic and non-neoplastic lymphoproliferative disorders. In: American Journal of Surgical Pathology. 2010 ; Vol. 34, No. 5. pp. 645-655.
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Class III β-tubulin shows unique expression patterns in a variety of neoplastic and non-neoplastic lymphoproliferative disorders. / Yoon, Sun Och; Kim, Wook Youn; Go, Heounjeong; Paik, Jin Ho; Kim, Ji Eun; Kim, Young A.; Huh, Joo R.; Jeon, Yoon Kyung; Kim, Chul Woo.

In: American Journal of Surgical Pathology, Vol. 34, No. 5, 05.2010, p. 645-655.

Research output: Contribution to journalArticle

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AU - Yoon, Sun Och

AU - Kim, Wook Youn

AU - Go, Heounjeong

AU - Paik, Jin Ho

AU - Kim, Ji Eun

AU - Kim, Young A.

AU - Huh, Joo R.

AU - Jeon, Yoon Kyung

AU - Kim, Chul Woo

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N2 - Class III β-tubulin (TUBB3) expression in carcinoma is associated with resistance to tubulin-binding chemotherapeutic agents. Recently, follicular dendritic cells (FDCs) were reported to express TUBB3 under physiologic conditions. We investigated TUBB3 expression in a wide range of lymphoproliferative disorders using immunohistochemistry. Dual immunostaining for Bcl-6 and TUBB3 revealed that some germinal center B cells also express TUBB3 in addition to FDCs. In Hodgkin lymphomas (HLs), 47.1% (40/85) expressed TUBB3 in the tumor cells with an all-or-none pattern. TUBB3 expression in HL was more common in mixed cellularity type than nodular sclerosis type (P=0.032). Among non-HLs, 79.3% (23/29) of anaplastic large cell lymphoma (ALCL), 8% (2/25) of extranodal natural killer/T-cell lymphoma, and 75% (21/28) of Burkitt lymphoma showed TUBB3 expression with an all-or-none pattern. Of diffuse large B-cell lymphoma, 15.2% (32/210) expressed TUBB3 in a heterogeneous pattern. In ALCL, TUBB3 expression was more common in systemic ALCL than in primary cutaneous ALCL (P=0.046). Diffuse large B-cell lymphomas with a germinal center B-like subgroup exhibited TUBB3 expression more frequently than non-GCB-like subgroup (P=0.01). Otherwise, none of the 18 angioimmunoblastic T-cell lymphomas; 18 peripheral T-cell lymphomas, not otherwise specified; 12 follicular lymphomas; 62 marginal zone lymphomas; 7 mantle cell lymphomas; 8 small lymphocytic lymphomas; or 2 FDC sarcomas expressed TUBB3. In angioimmunoblastic T-cell lymphoma and Castleman disease, TUBB3 was positive in immunoblasts corresponding to Epstein-Barr virus-infected or Kaposi sarcoma herpes virus-infected cells. A variety of neoplastic and non-neoplastic lymphoproliferative disorders exhibited characteristic TUBB3 expression patterns; these results suggest potential for diagnostic utility, some insight into the pathobiology of TUBB3 expression, and potential therapeutic implications.

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