Classifying the linkage between adipose tissue inflammation and tumor growth through cancer-associated adipocytes

Yae Chan Song, Seung Eon Lee, Young Jin, Hyun Woo Park, Kyung Hee Chun, Han Woong Lee

Research output: Contribution to journalShort surveypeer-review

Abstract

Recently, tumor microenvironment (TME) and its stromal constituents have provided profound insights into understanding alterations in tumor behavior. After each identification regarding the unique roles of TME compartments, non-malignant stromal cells are found to provide a sufficient tumorigenic niche for cancer cells. Of these TME constituents, adipocytes represent a dynamic population mediating endocrine effects to facilitate the crosstalk between cancer cells and distant organs, as well as the interplay with nearby tumor cells. To date, the prevalence of obesity has emphasized the significance of metabolic homeostasis along with adipose tissue (AT) inflammation, cancer incidence, and multiple pathological disorders. In this review, we summarized distinct characteristics of hypertrophic adipocytes and cancer to highlight the importance of an individual's metabolic health during cancer therapy. As AT undergoes inflammatory alterations inducing tissue remodeling, immune cell infiltration, and vascularization, these features directly influence the TME by favoring tumor progression. A comparison between inflammatory AT and progressing cancer could potentially provide crucial insights into delineating the complex communication network between uncontrolled hyperplastic tumors and their microenvironmental components. In turn, the comparison will unravel the underlying properties of dynamic tumor behavior, advocating possible therapeutic targets within TME constituents.

Original languageEnglish
Pages (from-to)763-773
Number of pages11
JournalMolecules and cells
Volume43
Issue number9
DOIs
Publication statusPublished - 2020 Sep 30

Bibliographical note

Funding Information:
This work was supported by the grant from the National Research Foundation of Korea (NRF) funded by the MEST (2018R1A2A1A05022746, 2017R1A4A1015328), and was supported in part by Brain Korea 21 (BK21) PLUS program.

All Science Journal Classification (ASJC) codes

  • Molecular Biology
  • Cell Biology

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