Claudin-7 is highly expressed in chromophobe renal cell carcinoma and renal oncocytoma

Duk Choi Yoo, Seung Kim Ki, Sunhyo Ryu, Youngkyu Park, Hoon Cho Nam, Hee Rha Seo, June Jang Ja, Jae Y. Ro, Woo Juhng Sang, Chan Choi

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Abstract

Claudin-7 has recently been suggested to be a distal nephron marker. We tested the possibility that expression of claudin-7 could be used as a marker of renal tumors originating from the distal nephron. We examined the immunohistochemical expression of claudin-7 and parvalbumin in 239 renal tumors, including 179 clear cell renal cell carcinoma (RCC)s, 29 papillary RCCs, 20 chromophobe RCCs, and 11 renal oncocytomas. In addition, the methylation specific-PCR (MSP) of claudin-7 was performed. Claudin-7 and parvalbumin immunostains were positive in 3.4%, 7.8% of clear cell RCCs, 34.5%, 31.0% of papillary RCCs, 95.0%, 80.0% of chromophobe RCCs, and 72.7%, 81.8% of renal oncocytomas, respectively. The sensitivity and specificity of claudin-7 in diagnosing chromophobe RCC among subtypes of RCC were 95.0% and 92.3%. Those of parvalbumin were 80.0% and 88.9%. The expression pattern of claudin-7 was mostly diffuse in chromophobe RCC and was either focal or diffuse in oncocytoma. All of the cases examined in the MSP revealed the presence of unmethylated promoter of claudin-7 without regard to claudin-7 immunoreactivity. Hypermethylation of the promoter might not be the underlying mechanism for loss of its expression in RCC. Claudin-7 can be used as a useful diagnostic marker in diagnosing chromophobe RCC and oncocytoma.

Original languageEnglish
Pages (from-to)305-310
Number of pages6
JournalJournal of Korean medical science
Volume22
Issue number2
DOIs
Publication statusPublished - 2007 Apr

All Science Journal Classification (ASJC) codes

  • Medicine(all)

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    Yoo, D. C., Ki, S. K., Ryu, S., Park, Y., Nam, H. C., Seo, H. R., Ja, J. J., Ro, J. Y., Sang, W. J., & Choi, C. (2007). Claudin-7 is highly expressed in chromophobe renal cell carcinoma and renal oncocytoma. Journal of Korean medical science, 22(2), 305-310. https://doi.org/10.3346/jkms.2007.22.2.305