Clec14a is a member of the thrombomodulin (TM) family, but its function has not yet been determined. Here, we report that Clec14a is a plasma membrane protein of endothelial cells (ECs) expressed specifically in the vasculature of mice. Deletion mutant analysis revealed that Clec14a mediates cell-cell adhesion through its C-type lectin-like domain. Knockdown of Clec14a in ECs suppressed cell migratory activity and filopodial protrusion, and delayed formation of tube-like structures. These findings demonstrate that Clec14a is a novel EC-specific protein that appears to play a role in cell-cell adhesion and angiogenesis.
|Number of pages||6|
|Journal||Biochemical and Biophysical Research Communications|
|Publication status||Published - 2011 Jan 7|
Bibliographical noteFunding Information:
This work was supported by a National Research Laboratory Grant (20100018854) and the Korea Biotech R&D Group of Next-generation growth engine project (2010K0012733-08A0301-00310) from the Ministry of Education and Science Technology, and a grant from the Korea Health 21 R&D Project, Ministry of Health Welfare & Family Affairs (A085136), Korea.
All Science Journal Classification (ASJC) codes
- Molecular Biology
- Cell Biology