Clinical and economic burden of invasive pneumococcal disease in adults

A multicenter hospital-based study

Joon Young Song, JunYong Choi, Jin Soo Lee, In Gyu Bae, YoungKeun Kim, Jang Wook Sohn, Yu Mi Jo, Won Suk Choi, Jacob Lee, Kyung Hwa Park, Woo Joo Kim, Hee Jin Cheong

Research output: Contribution to journalArticle

24 Citations (Scopus)

Abstract

Background: Streptococcus pneumoniae causes a broad spectrum of illnesses ranging from mild upper respiratory tract infections to invasive pneumococcal disease (IPD). Quantitative data on the burden of pneumococcal disease, important for the establishment of appropriate vaccination strategies, is currently lacking in adults.Methods: This multicenter, retrospective cohort study was designed to estimate the clinical and economic burden of IPD in adults over the last decade. Data were collected from patients with IPD at 10 university hospitals in South Korea. We estimated the proportion of IPD among all hospitalized patients, the case fatality rate, and the direct medical costs of IPD. Data were further analyzed according to age and risk groups.Results: During the study period, 970 patients with IPD were identified. The mean age for all patients was 60.9 years; patients aged 50-64 years (33.0%) were most numerous, followed by those aged 65-74 years (27.4%). Overall, the proportion of IPD was 0.36 cases/1000 hospitalized patients and the case fatality rate was 30.9%, which increased significantly with age (p < 0.01). The mean direct medical costs were estimated to be US $7,452 without a difference between age and risk groups. On multivariate analysis, old age, advanced ECOG performance status, bacteremic pneumonia, and nosocomial infection were independent risk factors of 30-day case fatality.Conclusions: The clinical disease burden of IPD increased significantly with age and direct medical costs from IPD were substantial, regardless of age and co-morbid conditions. The current age-based vaccination strategy appears to be appropriate.

Original languageEnglish
Article number202
JournalBMC Infectious Diseases
Volume13
Issue number1
DOIs
Publication statusPublished - 2013 May 4

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Economics
Costs and Cost Analysis
Vaccination
Age Groups
Republic of Korea
Mortality
Cross Infection
Streptococcus pneumoniae
Respiratory Tract Infections
Pneumonia
Cohort Studies
Multivariate Analysis
Retrospective Studies

All Science Journal Classification (ASJC) codes

  • Infectious Diseases

Cite this

Song, Joon Young ; Choi, JunYong ; Lee, Jin Soo ; Bae, In Gyu ; Kim, YoungKeun ; Sohn, Jang Wook ; Jo, Yu Mi ; Choi, Won Suk ; Lee, Jacob ; Park, Kyung Hwa ; Kim, Woo Joo ; Cheong, Hee Jin. / Clinical and economic burden of invasive pneumococcal disease in adults : A multicenter hospital-based study. In: BMC Infectious Diseases. 2013 ; Vol. 13, No. 1.
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abstract = "Background: Streptococcus pneumoniae causes a broad spectrum of illnesses ranging from mild upper respiratory tract infections to invasive pneumococcal disease (IPD). Quantitative data on the burden of pneumococcal disease, important for the establishment of appropriate vaccination strategies, is currently lacking in adults.Methods: This multicenter, retrospective cohort study was designed to estimate the clinical and economic burden of IPD in adults over the last decade. Data were collected from patients with IPD at 10 university hospitals in South Korea. We estimated the proportion of IPD among all hospitalized patients, the case fatality rate, and the direct medical costs of IPD. Data were further analyzed according to age and risk groups.Results: During the study period, 970 patients with IPD were identified. The mean age for all patients was 60.9 years; patients aged 50-64 years (33.0{\%}) were most numerous, followed by those aged 65-74 years (27.4{\%}). Overall, the proportion of IPD was 0.36 cases/1000 hospitalized patients and the case fatality rate was 30.9{\%}, which increased significantly with age (p < 0.01). The mean direct medical costs were estimated to be US $7,452 without a difference between age and risk groups. On multivariate analysis, old age, advanced ECOG performance status, bacteremic pneumonia, and nosocomial infection were independent risk factors of 30-day case fatality.Conclusions: The clinical disease burden of IPD increased significantly with age and direct medical costs from IPD were substantial, regardless of age and co-morbid conditions. The current age-based vaccination strategy appears to be appropriate.",
author = "Song, {Joon Young} and JunYong Choi and Lee, {Jin Soo} and Bae, {In Gyu} and YoungKeun Kim and Sohn, {Jang Wook} and Jo, {Yu Mi} and Choi, {Won Suk} and Jacob Lee and Park, {Kyung Hwa} and Kim, {Woo Joo} and Cheong, {Hee Jin}",
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Song, JY, Choi, J, Lee, JS, Bae, IG, Kim, Y, Sohn, JW, Jo, YM, Choi, WS, Lee, J, Park, KH, Kim, WJ & Cheong, HJ 2013, 'Clinical and economic burden of invasive pneumococcal disease in adults: A multicenter hospital-based study', BMC Infectious Diseases, vol. 13, no. 1, 202. https://doi.org/10.1186/1471-2334-13-202

Clinical and economic burden of invasive pneumococcal disease in adults : A multicenter hospital-based study. / Song, Joon Young; Choi, JunYong; Lee, Jin Soo; Bae, In Gyu; Kim, YoungKeun; Sohn, Jang Wook; Jo, Yu Mi; Choi, Won Suk; Lee, Jacob; Park, Kyung Hwa; Kim, Woo Joo; Cheong, Hee Jin.

In: BMC Infectious Diseases, Vol. 13, No. 1, 202, 04.05.2013.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Clinical and economic burden of invasive pneumococcal disease in adults

T2 - A multicenter hospital-based study

AU - Song, Joon Young

AU - Choi, JunYong

AU - Lee, Jin Soo

AU - Bae, In Gyu

AU - Kim, YoungKeun

AU - Sohn, Jang Wook

AU - Jo, Yu Mi

AU - Choi, Won Suk

AU - Lee, Jacob

AU - Park, Kyung Hwa

AU - Kim, Woo Joo

AU - Cheong, Hee Jin

PY - 2013/5/4

Y1 - 2013/5/4

N2 - Background: Streptococcus pneumoniae causes a broad spectrum of illnesses ranging from mild upper respiratory tract infections to invasive pneumococcal disease (IPD). Quantitative data on the burden of pneumococcal disease, important for the establishment of appropriate vaccination strategies, is currently lacking in adults.Methods: This multicenter, retrospective cohort study was designed to estimate the clinical and economic burden of IPD in adults over the last decade. Data were collected from patients with IPD at 10 university hospitals in South Korea. We estimated the proportion of IPD among all hospitalized patients, the case fatality rate, and the direct medical costs of IPD. Data were further analyzed according to age and risk groups.Results: During the study period, 970 patients with IPD were identified. The mean age for all patients was 60.9 years; patients aged 50-64 years (33.0%) were most numerous, followed by those aged 65-74 years (27.4%). Overall, the proportion of IPD was 0.36 cases/1000 hospitalized patients and the case fatality rate was 30.9%, which increased significantly with age (p < 0.01). The mean direct medical costs were estimated to be US $7,452 without a difference between age and risk groups. On multivariate analysis, old age, advanced ECOG performance status, bacteremic pneumonia, and nosocomial infection were independent risk factors of 30-day case fatality.Conclusions: The clinical disease burden of IPD increased significantly with age and direct medical costs from IPD were substantial, regardless of age and co-morbid conditions. The current age-based vaccination strategy appears to be appropriate.

AB - Background: Streptococcus pneumoniae causes a broad spectrum of illnesses ranging from mild upper respiratory tract infections to invasive pneumococcal disease (IPD). Quantitative data on the burden of pneumococcal disease, important for the establishment of appropriate vaccination strategies, is currently lacking in adults.Methods: This multicenter, retrospective cohort study was designed to estimate the clinical and economic burden of IPD in adults over the last decade. Data were collected from patients with IPD at 10 university hospitals in South Korea. We estimated the proportion of IPD among all hospitalized patients, the case fatality rate, and the direct medical costs of IPD. Data were further analyzed according to age and risk groups.Results: During the study period, 970 patients with IPD were identified. The mean age for all patients was 60.9 years; patients aged 50-64 years (33.0%) were most numerous, followed by those aged 65-74 years (27.4%). Overall, the proportion of IPD was 0.36 cases/1000 hospitalized patients and the case fatality rate was 30.9%, which increased significantly with age (p < 0.01). The mean direct medical costs were estimated to be US $7,452 without a difference between age and risk groups. On multivariate analysis, old age, advanced ECOG performance status, bacteremic pneumonia, and nosocomial infection were independent risk factors of 30-day case fatality.Conclusions: The clinical disease burden of IPD increased significantly with age and direct medical costs from IPD were substantial, regardless of age and co-morbid conditions. The current age-based vaccination strategy appears to be appropriate.

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