Clinical and electroencephalographic features of infantile spasms associated with malformations of cortical development

Chul Kang Hoon, Soon Hwang Yong, Chae Park Jung, Ho Cho Woo, Hee Kim Soung, Dong Kim Heung, Keun Park Sang

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

The aim of this study was to reveal the clinical and encephalographic (EEG) features of infantile spasms (IS) with malformations of cortical development (MCDs). The clinical features, EEG findings, neuroimaging studies and outcomes of various therapeutic modalities for 27 patients with IS and MCDs were reviewed. Background activities of EEG on the MCDs, i.e. asymmetric hypsarrhythmia, localized persistent polymorphic slowing, asymmetric slowing and diffuse fast activities, were shown in 22, 15, 9 and 2 patients, respectively. Partial epileptiform discharges such as localized paroxysmal fast activities, spindle-shaped fast activities and subclinical seizures were shown in 15, 8 and 10 patients, respectively, and the lateralized prominence of generalized paroxysmal fast activities and generalized sharp and wave discharges in 4 and 5 patients, respectively. MCDs were suspected in 5 patients, as revealed by EEG and/or functional neuroimagings without distinct magnetic resonance imaging lesions, and confirmed by pathologic findings. Of the 11 patients treated with surgical resection, 8 became seizure free. EEG features can be very useful in the identification of underlying cortical dysgenesis in patients with IS. However, in one patient who underwent epilepsy surgery in early infancy, we observed easy bleeding and difficult hemostasis from friable vascular and parenchymal tissues. Various EEG features can be very useful in screening underlying MCDs. In addition, epilepsy surgery can be an effective therapeutic modality in many patients with otherwise medically intractable IS with MCDs. However, surgical intervention in extremely young infants should be performed with caution.

Original languageEnglish
Pages (from-to)20-27
Number of pages8
JournalPediatric Neurosurgery
Volume42
Issue number1
DOIs
Publication statusPublished - 2005 Dec 1

Fingerprint

Infantile Spasms
Malformations of Cortical Development
Epilepsy
Functional Neuroimaging
Partial Epilepsy
Hemostasis
Neuroimaging
Blood Vessels
Seizures
Magnetic Resonance Imaging
Outcome Assessment (Health Care)
Hemorrhage

All Science Journal Classification (ASJC) codes

  • Pediatrics, Perinatology, and Child Health
  • Surgery
  • Clinical Neurology

Cite this

Hoon, Chul Kang ; Yong, Soon Hwang ; Jung, Chae Park ; Woo, Ho Cho ; Soung, Hee Kim ; Heung, Dong Kim ; Sang, Keun Park. / Clinical and electroencephalographic features of infantile spasms associated with malformations of cortical development. In: Pediatric Neurosurgery. 2005 ; Vol. 42, No. 1. pp. 20-27.
@article{ccb4317b32324a1294e96ddba7acd52e,
title = "Clinical and electroencephalographic features of infantile spasms associated with malformations of cortical development",
abstract = "The aim of this study was to reveal the clinical and encephalographic (EEG) features of infantile spasms (IS) with malformations of cortical development (MCDs). The clinical features, EEG findings, neuroimaging studies and outcomes of various therapeutic modalities for 27 patients with IS and MCDs were reviewed. Background activities of EEG on the MCDs, i.e. asymmetric hypsarrhythmia, localized persistent polymorphic slowing, asymmetric slowing and diffuse fast activities, were shown in 22, 15, 9 and 2 patients, respectively. Partial epileptiform discharges such as localized paroxysmal fast activities, spindle-shaped fast activities and subclinical seizures were shown in 15, 8 and 10 patients, respectively, and the lateralized prominence of generalized paroxysmal fast activities and generalized sharp and wave discharges in 4 and 5 patients, respectively. MCDs were suspected in 5 patients, as revealed by EEG and/or functional neuroimagings without distinct magnetic resonance imaging lesions, and confirmed by pathologic findings. Of the 11 patients treated with surgical resection, 8 became seizure free. EEG features can be very useful in the identification of underlying cortical dysgenesis in patients with IS. However, in one patient who underwent epilepsy surgery in early infancy, we observed easy bleeding and difficult hemostasis from friable vascular and parenchymal tissues. Various EEG features can be very useful in screening underlying MCDs. In addition, epilepsy surgery can be an effective therapeutic modality in many patients with otherwise medically intractable IS with MCDs. However, surgical intervention in extremely young infants should be performed with caution.",
author = "Hoon, {Chul Kang} and Yong, {Soon Hwang} and Jung, {Chae Park} and Woo, {Ho Cho} and Soung, {Hee Kim} and Heung, {Dong Kim} and Sang, {Keun Park}",
year = "2005",
month = "12",
day = "1",
doi = "10.1159/000089505",
language = "English",
volume = "42",
pages = "20--27",
journal = "Pediatric Neurosurgery",
issn = "1016-2291",
publisher = "S. Karger AG",
number = "1",

}

Clinical and electroencephalographic features of infantile spasms associated with malformations of cortical development. / Hoon, Chul Kang; Yong, Soon Hwang; Jung, Chae Park; Woo, Ho Cho; Soung, Hee Kim; Heung, Dong Kim; Sang, Keun Park.

In: Pediatric Neurosurgery, Vol. 42, No. 1, 01.12.2005, p. 20-27.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Clinical and electroencephalographic features of infantile spasms associated with malformations of cortical development

AU - Hoon, Chul Kang

AU - Yong, Soon Hwang

AU - Jung, Chae Park

AU - Woo, Ho Cho

AU - Soung, Hee Kim

AU - Heung, Dong Kim

AU - Sang, Keun Park

PY - 2005/12/1

Y1 - 2005/12/1

N2 - The aim of this study was to reveal the clinical and encephalographic (EEG) features of infantile spasms (IS) with malformations of cortical development (MCDs). The clinical features, EEG findings, neuroimaging studies and outcomes of various therapeutic modalities for 27 patients with IS and MCDs were reviewed. Background activities of EEG on the MCDs, i.e. asymmetric hypsarrhythmia, localized persistent polymorphic slowing, asymmetric slowing and diffuse fast activities, were shown in 22, 15, 9 and 2 patients, respectively. Partial epileptiform discharges such as localized paroxysmal fast activities, spindle-shaped fast activities and subclinical seizures were shown in 15, 8 and 10 patients, respectively, and the lateralized prominence of generalized paroxysmal fast activities and generalized sharp and wave discharges in 4 and 5 patients, respectively. MCDs were suspected in 5 patients, as revealed by EEG and/or functional neuroimagings without distinct magnetic resonance imaging lesions, and confirmed by pathologic findings. Of the 11 patients treated with surgical resection, 8 became seizure free. EEG features can be very useful in the identification of underlying cortical dysgenesis in patients with IS. However, in one patient who underwent epilepsy surgery in early infancy, we observed easy bleeding and difficult hemostasis from friable vascular and parenchymal tissues. Various EEG features can be very useful in screening underlying MCDs. In addition, epilepsy surgery can be an effective therapeutic modality in many patients with otherwise medically intractable IS with MCDs. However, surgical intervention in extremely young infants should be performed with caution.

AB - The aim of this study was to reveal the clinical and encephalographic (EEG) features of infantile spasms (IS) with malformations of cortical development (MCDs). The clinical features, EEG findings, neuroimaging studies and outcomes of various therapeutic modalities for 27 patients with IS and MCDs were reviewed. Background activities of EEG on the MCDs, i.e. asymmetric hypsarrhythmia, localized persistent polymorphic slowing, asymmetric slowing and diffuse fast activities, were shown in 22, 15, 9 and 2 patients, respectively. Partial epileptiform discharges such as localized paroxysmal fast activities, spindle-shaped fast activities and subclinical seizures were shown in 15, 8 and 10 patients, respectively, and the lateralized prominence of generalized paroxysmal fast activities and generalized sharp and wave discharges in 4 and 5 patients, respectively. MCDs were suspected in 5 patients, as revealed by EEG and/or functional neuroimagings without distinct magnetic resonance imaging lesions, and confirmed by pathologic findings. Of the 11 patients treated with surgical resection, 8 became seizure free. EEG features can be very useful in the identification of underlying cortical dysgenesis in patients with IS. However, in one patient who underwent epilepsy surgery in early infancy, we observed easy bleeding and difficult hemostasis from friable vascular and parenchymal tissues. Various EEG features can be very useful in screening underlying MCDs. In addition, epilepsy surgery can be an effective therapeutic modality in many patients with otherwise medically intractable IS with MCDs. However, surgical intervention in extremely young infants should be performed with caution.

UR - http://www.scopus.com/inward/record.url?scp=29144501410&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=29144501410&partnerID=8YFLogxK

U2 - 10.1159/000089505

DO - 10.1159/000089505

M3 - Article

C2 - 16357497

AN - SCOPUS:29144501410

VL - 42

SP - 20

EP - 27

JO - Pediatric Neurosurgery

JF - Pediatric Neurosurgery

SN - 1016-2291

IS - 1

ER -