Clinical and Electrophysiological Characteristics of Radiofrequency Catheter Ablation in Patients with Clinically Significant Sinus Node Dysfunction and Atrial Fibrillation

Jae Sun Uhm, Boyoung Joung, Hye Jin Hwang, Jong Youn Kim, Moon Hyoung Lee, huinam pak

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Backgrounds: We evaluated that electrphysiological characteristics and clinical outcomes of atrial fibrillation (AF) with sinus node dysfunction (SND) after radiofrequency Catheter ablation (RFCA). Methods: Among 428 patients (male, 77.3%; 56.0 + 11.0 years old; paroxysmal AF, 69.4%) who underwent RFCA for AF, 50 patients (11.7%) who had ECG documented symptomatic SND (28 Tachybrady (T-Bs) and 22 sick sinus syndrome; SSS) were compared with 378 patients without SND. Results: 1. The patients with SND were older (60.3 ±61617;9.7 vs. 55.4 ± 61617;11.1 years, p=0.003) and had higher E/E ' (12.4±61617;5.1 vs. 9.9±61617;4.1, p=0.002) than those without SND. 2. Effective refractory period (ERP) at high right atrium (RA) was longer (ERP; 244.1 ±61617;26.1 vs. 232.2 + 61617;28.2 ms, p=0.033) and endocardial voltage at posterior left atrium (LA) was higher (1.2 ±61617;0.8 vs. 0.9±61617;0.8 mV, p=0.041) in patients with SND than those without it. 3. The recurrence rate was not different significantly between groups (28.0% vs. 20.0%, p=0.623) during 12.7 + 5.9 months. A patient with SSS (4.5%) and a patient with T-Bs (3.6%) were implanted pacemaker because of recurrent symptomatic bradycardia after RFCA. Conclusion: AF is associated with SND more often in patients with old age, diastolic dysfunction, and high RA ERP. RFCA results in comparable clinical outcome in those patients, but 4% of them required pacemaker implantation due to AF recurrence and symptomatic bradycardia.

Original languageEnglish
Number of pages1
JournalJournal of Arrhythmia
Issue number4
Publication statusPublished - 2011 Jan 1


All Science Journal Classification (ASJC) codes

  • Cardiology and Cardiovascular Medicine

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