Clinical and laboratory predictors of oliguric renal failure in haemorrhagic fever with renal syndrome caused by Hantaan virus

Young Keun Kim, Sang Cheol Lee, Changsoo Kim, Sang Taek Heo, Changmin Choi, June Myung Kim

Research output: Contribution to journalArticle

16 Citations (Scopus)

Abstract

Objective: Haemorrhagic fever with renal syndrome (HFRS), caused by hantavirus infection, develops into acute renal failure (ARF) of variable degrees of severity. We investigated the early predictive markers for oliguric ARF in HFRS patients. Methods: A retrospective cohort study was performed of 61 patients with HFRS between 2000 and 2004. These patients were categorized into either oliguric or non-oliguric ARF groups according to their urine output (<400 ml/24 h). The clinical characteristics were compared between the two groups. Results: Of the 61 patients, 24 (39.3%) were classified as oliguric ARF and 37 (60.7%) as non-oliguric ARF. The peak serum Cr was 10.8 (IQR 9.1-12.4) mg/dl in oliguric ARF and 4.4 (IQR 3.1-6.0) mg/dl in non-oliguric ARF (p < 0.001). The risk for developing oliguric ARF significantly increased in the cases with leukocyte count (≥14 × 109/L, aOR 2.2, 95% CI 1.0-4.9; p = 0.039), elevated aspartate aminotransferase (≥110 U/L, aOR 11.0, 95% CI 2.1-57.9; p = 0.005) and the presence of microscopic haematuria (≥5/HPF, aOR 9.2, 95% CI 1.4-60.3; p = 0.021) at the time of admission. Conclusion: The leukocyte count, level of aspartate aminotransferase and microscopic haematuria at admission would be useful to predict for the subsequent development of oliguric ARF in HFRS.

Original languageEnglish
Pages (from-to)381-386
Number of pages6
JournalJournal of Infection
Volume54
Issue number4
DOIs
Publication statusPublished - 2007 Apr 1

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Hantaan virus
Hemorrhagic Fever with Renal Syndrome
Acute Kidney Injury
Renal Insufficiency
Hematuria
Aspartate Aminotransferases
Leukocyte Count
Hantavirus Infections
Cohort Studies
Retrospective Studies
Urine

All Science Journal Classification (ASJC) codes

  • Microbiology (medical)
  • Infectious Diseases

Cite this

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title = "Clinical and laboratory predictors of oliguric renal failure in haemorrhagic fever with renal syndrome caused by Hantaan virus",
abstract = "Objective: Haemorrhagic fever with renal syndrome (HFRS), caused by hantavirus infection, develops into acute renal failure (ARF) of variable degrees of severity. We investigated the early predictive markers for oliguric ARF in HFRS patients. Methods: A retrospective cohort study was performed of 61 patients with HFRS between 2000 and 2004. These patients were categorized into either oliguric or non-oliguric ARF groups according to their urine output (<400 ml/24 h). The clinical characteristics were compared between the two groups. Results: Of the 61 patients, 24 (39.3{\%}) were classified as oliguric ARF and 37 (60.7{\%}) as non-oliguric ARF. The peak serum Cr was 10.8 (IQR 9.1-12.4) mg/dl in oliguric ARF and 4.4 (IQR 3.1-6.0) mg/dl in non-oliguric ARF (p < 0.001). The risk for developing oliguric ARF significantly increased in the cases with leukocyte count (≥14 × 109/L, aOR 2.2, 95{\%} CI 1.0-4.9; p = 0.039), elevated aspartate aminotransferase (≥110 U/L, aOR 11.0, 95{\%} CI 2.1-57.9; p = 0.005) and the presence of microscopic haematuria (≥5/HPF, aOR 9.2, 95{\%} CI 1.4-60.3; p = 0.021) at the time of admission. Conclusion: The leukocyte count, level of aspartate aminotransferase and microscopic haematuria at admission would be useful to predict for the subsequent development of oliguric ARF in HFRS.",
author = "Kim, {Young Keun} and Lee, {Sang Cheol} and Changsoo Kim and Heo, {Sang Taek} and Changmin Choi and Kim, {June Myung}",
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Clinical and laboratory predictors of oliguric renal failure in haemorrhagic fever with renal syndrome caused by Hantaan virus. / Kim, Young Keun; Lee, Sang Cheol; Kim, Changsoo; Heo, Sang Taek; Choi, Changmin; Kim, June Myung.

In: Journal of Infection, Vol. 54, No. 4, 01.04.2007, p. 381-386.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Clinical and laboratory predictors of oliguric renal failure in haemorrhagic fever with renal syndrome caused by Hantaan virus

AU - Kim, Young Keun

AU - Lee, Sang Cheol

AU - Kim, Changsoo

AU - Heo, Sang Taek

AU - Choi, Changmin

AU - Kim, June Myung

PY - 2007/4/1

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N2 - Objective: Haemorrhagic fever with renal syndrome (HFRS), caused by hantavirus infection, develops into acute renal failure (ARF) of variable degrees of severity. We investigated the early predictive markers for oliguric ARF in HFRS patients. Methods: A retrospective cohort study was performed of 61 patients with HFRS between 2000 and 2004. These patients were categorized into either oliguric or non-oliguric ARF groups according to their urine output (<400 ml/24 h). The clinical characteristics were compared between the two groups. Results: Of the 61 patients, 24 (39.3%) were classified as oliguric ARF and 37 (60.7%) as non-oliguric ARF. The peak serum Cr was 10.8 (IQR 9.1-12.4) mg/dl in oliguric ARF and 4.4 (IQR 3.1-6.0) mg/dl in non-oliguric ARF (p < 0.001). The risk for developing oliguric ARF significantly increased in the cases with leukocyte count (≥14 × 109/L, aOR 2.2, 95% CI 1.0-4.9; p = 0.039), elevated aspartate aminotransferase (≥110 U/L, aOR 11.0, 95% CI 2.1-57.9; p = 0.005) and the presence of microscopic haematuria (≥5/HPF, aOR 9.2, 95% CI 1.4-60.3; p = 0.021) at the time of admission. Conclusion: The leukocyte count, level of aspartate aminotransferase and microscopic haematuria at admission would be useful to predict for the subsequent development of oliguric ARF in HFRS.

AB - Objective: Haemorrhagic fever with renal syndrome (HFRS), caused by hantavirus infection, develops into acute renal failure (ARF) of variable degrees of severity. We investigated the early predictive markers for oliguric ARF in HFRS patients. Methods: A retrospective cohort study was performed of 61 patients with HFRS between 2000 and 2004. These patients were categorized into either oliguric or non-oliguric ARF groups according to their urine output (<400 ml/24 h). The clinical characteristics were compared between the two groups. Results: Of the 61 patients, 24 (39.3%) were classified as oliguric ARF and 37 (60.7%) as non-oliguric ARF. The peak serum Cr was 10.8 (IQR 9.1-12.4) mg/dl in oliguric ARF and 4.4 (IQR 3.1-6.0) mg/dl in non-oliguric ARF (p < 0.001). The risk for developing oliguric ARF significantly increased in the cases with leukocyte count (≥14 × 109/L, aOR 2.2, 95% CI 1.0-4.9; p = 0.039), elevated aspartate aminotransferase (≥110 U/L, aOR 11.0, 95% CI 2.1-57.9; p = 0.005) and the presence of microscopic haematuria (≥5/HPF, aOR 9.2, 95% CI 1.4-60.3; p = 0.021) at the time of admission. Conclusion: The leukocyte count, level of aspartate aminotransferase and microscopic haematuria at admission would be useful to predict for the subsequent development of oliguric ARF in HFRS.

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