Clinical and molecular characteristics of community-acquired Clostridium difficile infections in comparison with those of hospital-acquired C. difficile

Soon Sung Kwon, Jung Lim Gim, Myung Sook Kim, Heejung Kim, JunYong Choi, DongEun Yong, Kyungwon Lee

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Community-acquired Clostridium difficile infection (CA-CDI) is a growing concern. CA-CDI differs from hospital-acquired C. difficile infection (HA-CDI) in its epidemiology, risk factors, severity, and outcomes. In this study, we investigated C. difficile infections in a tertiary care hospital in Seoul, Korea, and compared the CA-CDI and HA-CDI cases diagnosed in the same period. Total 593 cases were confirmed as CDI in 2014, of which CA-CDI accounted for 68 (11.5%) of the total CDI cases. Compared with HA-CDI, the mean age of CA-CDI cases was lower than that of HA-CDI (42.7 vs 60.4). In CA-CDI, antibiotic and proton pump inhibitor (PPI) use in the 12 preceding weeks and concurrent chemotherapy and tube feeding were less frequent compared with HA-CDI. In most cases (63/68, 92.6%), patients with CA-CDI recovered without any complications or recurrence. The most prevalent C. difficile type in CA-CDI cases was PCR-ribotype 012, accounting for 18.3% of the total, followed by PCR-ribotype 018 (16.7%).

Original languageEnglish
Pages (from-to)42-46
Number of pages5
JournalAnaerobe
Volume48
DOIs
Publication statusPublished - 2017 Dec 1

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Clostridium Infections
Clostridium difficile
Ribotyping
Polymerase Chain Reaction
Proton Pump Inhibitors
Enteral Nutrition
Tertiary Healthcare
Korea

All Science Journal Classification (ASJC) codes

  • Microbiology
  • Infectious Diseases

Cite this

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title = "Clinical and molecular characteristics of community-acquired Clostridium difficile infections in comparison with those of hospital-acquired C. difficile",
abstract = "Community-acquired Clostridium difficile infection (CA-CDI) is a growing concern. CA-CDI differs from hospital-acquired C. difficile infection (HA-CDI) in its epidemiology, risk factors, severity, and outcomes. In this study, we investigated C. difficile infections in a tertiary care hospital in Seoul, Korea, and compared the CA-CDI and HA-CDI cases diagnosed in the same period. Total 593 cases were confirmed as CDI in 2014, of which CA-CDI accounted for 68 (11.5{\%}) of the total CDI cases. Compared with HA-CDI, the mean age of CA-CDI cases was lower than that of HA-CDI (42.7 vs 60.4). In CA-CDI, antibiotic and proton pump inhibitor (PPI) use in the 12 preceding weeks and concurrent chemotherapy and tube feeding were less frequent compared with HA-CDI. In most cases (63/68, 92.6{\%}), patients with CA-CDI recovered without any complications or recurrence. The most prevalent C. difficile type in CA-CDI cases was PCR-ribotype 012, accounting for 18.3{\%} of the total, followed by PCR-ribotype 018 (16.7{\%}).",
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Clinical and molecular characteristics of community-acquired Clostridium difficile infections in comparison with those of hospital-acquired C. difficile. / Kwon, Soon Sung; Gim, Jung Lim; Kim, Myung Sook; Kim, Heejung; Choi, JunYong; Yong, DongEun; Lee, Kyungwon.

In: Anaerobe, Vol. 48, 01.12.2017, p. 42-46.

Research output: Contribution to journalArticle

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AU - Choi, JunYong

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AU - Lee, Kyungwon

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