Clinical and Molecular Characterization of Panton-Valentine Leukocidin-Positive Invasive Staphylococcus aureus Infections in Korea

Kyoung Ho Song, Eu Suk Kim, Kyung Hwa Park, Hee Jung Choi, Kye Hyung Kim, Shinwon Lee, Jeong Hwan Hwang, Eun Ju Choo, Yoonseon Park, Eun Jung Lee, YoungKeun Kim, Min Hyok Jeon, Chisook Moon, Joo Hee Hwang, Jeong Su Park, Kyoung Un Park, Pyoeng Gyun Choe, Ji Hwan Bang, Myoung Don Oh, Hong Bin Kim

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Aim: Panton-Valentine leukocidin (PVL) is a virulent cytotoxin and an indicator of community-associated methicillin-resistant Staphylococcus aureus (CA-MRSA) infection. In this study, we evaluated the prevalence and clinical and molecular characteristics of PVL-positive invasive S. aureus (ISA) infections in Korea. Results: A collection of 1,962 nonduplicate clinical isolates were screened for multilocus sequence typing, staphylococcal cassette chromosome mec (SCCmec), accessory gene regulator typing, major toxins, and antimicrobial susceptibility. Twenty-eight (1.4%) PVL-positive S. aureus samples were found; of them 19 (67.9%) were MRSA (8 CA and 11 healthcare-associated infections). Seventeen patients (60.7%) were men (median age: 63 years; range: 13-93 years) and 12 patients (42.9%) had no underlying comorbidities. The most common infections were skin and skin structure infection (SSSI) and pneumonia. The 30-day mortality rate was 37.0%. The most common PVL-positive MRSA clones were ST8-SCCmec IVa and ST30-SCCmec IVc along with their single-locus variants. Antimicrobial susceptibility and toxin-gene profile differed according to the clone. Conclusions: ISA infections caused by PVL-positive strains are rare in Korea, with the two most common infections being SSSI and pneumonia. Our findings indicated that several PVL-positive MRSA clones, predominantly ST8-SCCmecIVa and ST30-SCCmecIVc, were circulating and causing sporadic cases of ISA infections in the community and hospital settings.

Original languageEnglish
Pages (from-to)450-456
Number of pages7
JournalMicrobial Drug Resistance
Volume25
Issue number3
DOIs
Publication statusPublished - 2019 Apr 1

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Korea
Staphylococcus aureus
Methicillin-Resistant Staphylococcus aureus
Infection
Skin
Clone Cells
Chromosomes
Pneumonia
Multilocus Sequence Typing
Panton-Valentine leukocidin
Community Hospital
Cytotoxins
Regulator Genes
Cross Infection
Comorbidity
Mortality
Genes

All Science Journal Classification (ASJC) codes

  • Microbiology
  • Immunology
  • Pharmacology
  • Microbiology (medical)

Cite this

Song, Kyoung Ho ; Kim, Eu Suk ; Park, Kyung Hwa ; Choi, Hee Jung ; Kim, Kye Hyung ; Lee, Shinwon ; Hwang, Jeong Hwan ; Choo, Eun Ju ; Park, Yoonseon ; Lee, Eun Jung ; Kim, YoungKeun ; Jeon, Min Hyok ; Moon, Chisook ; Hwang, Joo Hee ; Park, Jeong Su ; Park, Kyoung Un ; Choe, Pyoeng Gyun ; Bang, Ji Hwan ; Oh, Myoung Don ; Kim, Hong Bin. / Clinical and Molecular Characterization of Panton-Valentine Leukocidin-Positive Invasive Staphylococcus aureus Infections in Korea. In: Microbial Drug Resistance. 2019 ; Vol. 25, No. 3. pp. 450-456.
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title = "Clinical and Molecular Characterization of Panton-Valentine Leukocidin-Positive Invasive Staphylococcus aureus Infections in Korea",
abstract = "Aim: Panton-Valentine leukocidin (PVL) is a virulent cytotoxin and an indicator of community-associated methicillin-resistant Staphylococcus aureus (CA-MRSA) infection. In this study, we evaluated the prevalence and clinical and molecular characteristics of PVL-positive invasive S. aureus (ISA) infections in Korea. Results: A collection of 1,962 nonduplicate clinical isolates were screened for multilocus sequence typing, staphylococcal cassette chromosome mec (SCCmec), accessory gene regulator typing, major toxins, and antimicrobial susceptibility. Twenty-eight (1.4{\%}) PVL-positive S. aureus samples were found; of them 19 (67.9{\%}) were MRSA (8 CA and 11 healthcare-associated infections). Seventeen patients (60.7{\%}) were men (median age: 63 years; range: 13-93 years) and 12 patients (42.9{\%}) had no underlying comorbidities. The most common infections were skin and skin structure infection (SSSI) and pneumonia. The 30-day mortality rate was 37.0{\%}. The most common PVL-positive MRSA clones were ST8-SCCmec IVa and ST30-SCCmec IVc along with their single-locus variants. Antimicrobial susceptibility and toxin-gene profile differed according to the clone. Conclusions: ISA infections caused by PVL-positive strains are rare in Korea, with the two most common infections being SSSI and pneumonia. Our findings indicated that several PVL-positive MRSA clones, predominantly ST8-SCCmecIVa and ST30-SCCmecIVc, were circulating and causing sporadic cases of ISA infections in the community and hospital settings.",
author = "Song, {Kyoung Ho} and Kim, {Eu Suk} and Park, {Kyung Hwa} and Choi, {Hee Jung} and Kim, {Kye Hyung} and Shinwon Lee and Hwang, {Jeong Hwan} and Choo, {Eun Ju} and Yoonseon Park and Lee, {Eun Jung} and YoungKeun Kim and Jeon, {Min Hyok} and Chisook Moon and Hwang, {Joo Hee} and Park, {Jeong Su} and Park, {Kyoung Un} and Choe, {Pyoeng Gyun} and Bang, {Ji Hwan} and Oh, {Myoung Don} and Kim, {Hong Bin}",
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Song, KH, Kim, ES, Park, KH, Choi, HJ, Kim, KH, Lee, S, Hwang, JH, Choo, EJ, Park, Y, Lee, EJ, Kim, Y, Jeon, MH, Moon, C, Hwang, JH, Park, JS, Park, KU, Choe, PG, Bang, JH, Oh, MD & Kim, HB 2019, 'Clinical and Molecular Characterization of Panton-Valentine Leukocidin-Positive Invasive Staphylococcus aureus Infections in Korea', Microbial Drug Resistance, vol. 25, no. 3, pp. 450-456. https://doi.org/10.1089/mdr.2018.0238

Clinical and Molecular Characterization of Panton-Valentine Leukocidin-Positive Invasive Staphylococcus aureus Infections in Korea. / Song, Kyoung Ho; Kim, Eu Suk; Park, Kyung Hwa; Choi, Hee Jung; Kim, Kye Hyung; Lee, Shinwon; Hwang, Jeong Hwan; Choo, Eun Ju; Park, Yoonseon; Lee, Eun Jung; Kim, YoungKeun; Jeon, Min Hyok; Moon, Chisook; Hwang, Joo Hee; Park, Jeong Su; Park, Kyoung Un; Choe, Pyoeng Gyun; Bang, Ji Hwan; Oh, Myoung Don; Kim, Hong Bin.

In: Microbial Drug Resistance, Vol. 25, No. 3, 01.04.2019, p. 450-456.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Clinical and Molecular Characterization of Panton-Valentine Leukocidin-Positive Invasive Staphylococcus aureus Infections in Korea

AU - Song, Kyoung Ho

AU - Kim, Eu Suk

AU - Park, Kyung Hwa

AU - Choi, Hee Jung

AU - Kim, Kye Hyung

AU - Lee, Shinwon

AU - Hwang, Jeong Hwan

AU - Choo, Eun Ju

AU - Park, Yoonseon

AU - Lee, Eun Jung

AU - Kim, YoungKeun

AU - Jeon, Min Hyok

AU - Moon, Chisook

AU - Hwang, Joo Hee

AU - Park, Jeong Su

AU - Park, Kyoung Un

AU - Choe, Pyoeng Gyun

AU - Bang, Ji Hwan

AU - Oh, Myoung Don

AU - Kim, Hong Bin

PY - 2019/4/1

Y1 - 2019/4/1

N2 - Aim: Panton-Valentine leukocidin (PVL) is a virulent cytotoxin and an indicator of community-associated methicillin-resistant Staphylococcus aureus (CA-MRSA) infection. In this study, we evaluated the prevalence and clinical and molecular characteristics of PVL-positive invasive S. aureus (ISA) infections in Korea. Results: A collection of 1,962 nonduplicate clinical isolates were screened for multilocus sequence typing, staphylococcal cassette chromosome mec (SCCmec), accessory gene regulator typing, major toxins, and antimicrobial susceptibility. Twenty-eight (1.4%) PVL-positive S. aureus samples were found; of them 19 (67.9%) were MRSA (8 CA and 11 healthcare-associated infections). Seventeen patients (60.7%) were men (median age: 63 years; range: 13-93 years) and 12 patients (42.9%) had no underlying comorbidities. The most common infections were skin and skin structure infection (SSSI) and pneumonia. The 30-day mortality rate was 37.0%. The most common PVL-positive MRSA clones were ST8-SCCmec IVa and ST30-SCCmec IVc along with their single-locus variants. Antimicrobial susceptibility and toxin-gene profile differed according to the clone. Conclusions: ISA infections caused by PVL-positive strains are rare in Korea, with the two most common infections being SSSI and pneumonia. Our findings indicated that several PVL-positive MRSA clones, predominantly ST8-SCCmecIVa and ST30-SCCmecIVc, were circulating and causing sporadic cases of ISA infections in the community and hospital settings.

AB - Aim: Panton-Valentine leukocidin (PVL) is a virulent cytotoxin and an indicator of community-associated methicillin-resistant Staphylococcus aureus (CA-MRSA) infection. In this study, we evaluated the prevalence and clinical and molecular characteristics of PVL-positive invasive S. aureus (ISA) infections in Korea. Results: A collection of 1,962 nonduplicate clinical isolates were screened for multilocus sequence typing, staphylococcal cassette chromosome mec (SCCmec), accessory gene regulator typing, major toxins, and antimicrobial susceptibility. Twenty-eight (1.4%) PVL-positive S. aureus samples were found; of them 19 (67.9%) were MRSA (8 CA and 11 healthcare-associated infections). Seventeen patients (60.7%) were men (median age: 63 years; range: 13-93 years) and 12 patients (42.9%) had no underlying comorbidities. The most common infections were skin and skin structure infection (SSSI) and pneumonia. The 30-day mortality rate was 37.0%. The most common PVL-positive MRSA clones were ST8-SCCmec IVa and ST30-SCCmec IVc along with their single-locus variants. Antimicrobial susceptibility and toxin-gene profile differed according to the clone. Conclusions: ISA infections caused by PVL-positive strains are rare in Korea, with the two most common infections being SSSI and pneumonia. Our findings indicated that several PVL-positive MRSA clones, predominantly ST8-SCCmecIVa and ST30-SCCmecIVc, were circulating and causing sporadic cases of ISA infections in the community and hospital settings.

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U2 - 10.1089/mdr.2018.0238

DO - 10.1089/mdr.2018.0238

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