Clinical and pathological features of generalized granuloma annulare with their correlation: A retrospective multicenter study in Korea

Jeong Hyun Yun, Ji Yeoun Lee, Mi Kyeong Kim, Young Joon Seo, Myung Hwa Kim, Kwang Hyun Cho, Moon Bum Kim, Won Soo Lee, Kwang Hoon Lee, You Chan Kim, Seok Jong Lee, Gwang Seong Choi, Young Ho Won, Chull Wan Ihm, Tae Young Yoon

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Abstract

Background: Generalized granuloma annulare (GGA) is a benign skin disorder of an unknown etiology. Though some cases of GGA have been reported, few systemic reviews of the clinical and pathological features of GGA have been performed. Objective: The purpose of this study is to analyze and correlate the clinical and pathological characteristics of GGA in Korean patients. Methods: We conducted a retrospective study that included 54 biopsy specimens of Korean GGA patients, and the clinical and pathological features of GGA were reviewed and analyzed for their correlation. Results: The cutaneous lesions could be divided into the annular (24, 44%) and nonannular types (30, 56%), and the esions were more common in males than in females (29 males and 25 females). The incidence of GGA showed a bimodal age distribution. The number of patients who prented within the first decade was 24 cases (44%), and 24 cases (44%) were over the fifth decade. Eight patients (15%) had systemic diseases. Especially, diabetes mellitus (DM) occurred only in the adult GGA patients over forty years old. The pathological findings showed dermal granulomatous lesions that consisted of either a palisading pattern (28, 52%) or an interstitial pattern (26,48%). Conclusion: In contrast to the previously reported studies, the age of GGA onset showed a bimodal distribution, and GGA was observed more often in males. The prevalence of DM in the GGA affected individuals was higher than that found in the general Korean population. Therefore, it is recommended to perform a work-up for DM in the GGA affected patients who are over forty years old. (Ann Dermatol 21(2) 113∼119, 2009).

Original languageEnglish
Pages (from-to)113-119
Number of pages7
JournalAnnals of Dermatology
Volume21
Issue number2
DOIs
Publication statusPublished - 2009

All Science Journal Classification (ASJC) codes

  • Dermatology

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    Yun, J. H., Lee, J. Y., Kim, M. K., Seo, Y. J., Kim, M. H., Cho, K. H., Kim, M. B., Lee, W. S., Lee, K. H., Kim, Y. C., Lee, S. J., Choi, G. S., Won, Y. H., Ihm, C. W., & Yoon, T. Y. (2009). Clinical and pathological features of generalized granuloma annulare with their correlation: A retrospective multicenter study in Korea. Annals of Dermatology, 21(2), 113-119. https://doi.org/10.5021/ad.2009.21.2.113