Clinical and pathological features of generalized granuloma annulare with their correlation

A retrospective multicenter study in Korea

Jeong Hyun Yun, Ji Yeoun Lee, Mi Kyeong Kim, Young Joon Seo, Myung Hwa Kim, Kwang Hyun Cho, Moon Bum Kim, Won Soo Lee, Kwanghoon Lee, You Chan Kim, Seok Jong Lee, Gwang Seong Choi, Young Ho Won, Chull Wan Ihm, Tae Young Yoon

Research output: Contribution to journalArticle

35 Citations (Scopus)

Abstract

Background: Generalized granuloma annulare (GGA) is a benign skin disorder of an unknown etiology. Though some cases of GGA have been reported, few systemic reviews of the clinical and pathological features of GGA have been performed. Objective: The purpose of this study is to analyze and correlate the clinical and pathological characteristics of GGA in Korean patients. Methods: We conducted a retrospective study that included 54 biopsy specimens of Korean GGA patients, and the clinical and pathological features of GGA were reviewed and analyzed for their correlation. Results: The cutaneous lesions could be divided into the annular (24, 44%) and nonannular types (30, 56%), and the esions were more common in males than in females (29 males and 25 females). The incidence of GGA showed a bimodal age distribution. The number of patients who prented within the first decade was 24 cases (44%), and 24 cases (44%) were over the fifth decade. Eight patients (15%) had systemic diseases. Especially, diabetes mellitus (DM) occurred only in the adult GGA patients over forty years old. The pathological findings showed dermal granulomatous lesions that consisted of either a palisading pattern (28, 52%) or an interstitial pattern (26,48%). Conclusion: In contrast to the previously reported studies, the age of GGA onset showed a bimodal distribution, and GGA was observed more often in males. The prevalence of DM in the GGA affected individuals was higher than that found in the general Korean population. Therefore, it is recommended to perform a work-up for DM in the GGA affected patients who are over forty years old. (Ann Dermatol 21(2) 113∼119, 2009).

Original languageEnglish
Pages (from-to)113-119
Number of pages7
JournalAnnals of Dermatology
Volume21
Issue number2
DOIs
Publication statusPublished - 2009 Dec 1

Fingerprint

Granuloma Annulare
Korea
Multicenter Studies
Retrospective Studies
Diabetes Mellitus
Skin
Age Distribution

All Science Journal Classification (ASJC) codes

  • Dermatology

Cite this

Yun, Jeong Hyun ; Lee, Ji Yeoun ; Kim, Mi Kyeong ; Seo, Young Joon ; Kim, Myung Hwa ; Cho, Kwang Hyun ; Kim, Moon Bum ; Lee, Won Soo ; Lee, Kwanghoon ; Kim, You Chan ; Lee, Seok Jong ; Choi, Gwang Seong ; Won, Young Ho ; Ihm, Chull Wan ; Yoon, Tae Young. / Clinical and pathological features of generalized granuloma annulare with their correlation : A retrospective multicenter study in Korea. In: Annals of Dermatology. 2009 ; Vol. 21, No. 2. pp. 113-119.
@article{d08e0f8cb24946f8b7bb921c043c435f,
title = "Clinical and pathological features of generalized granuloma annulare with their correlation: A retrospective multicenter study in Korea",
abstract = "Background: Generalized granuloma annulare (GGA) is a benign skin disorder of an unknown etiology. Though some cases of GGA have been reported, few systemic reviews of the clinical and pathological features of GGA have been performed. Objective: The purpose of this study is to analyze and correlate the clinical and pathological characteristics of GGA in Korean patients. Methods: We conducted a retrospective study that included 54 biopsy specimens of Korean GGA patients, and the clinical and pathological features of GGA were reviewed and analyzed for their correlation. Results: The cutaneous lesions could be divided into the annular (24, 44{\%}) and nonannular types (30, 56{\%}), and the esions were more common in males than in females (29 males and 25 females). The incidence of GGA showed a bimodal age distribution. The number of patients who prented within the first decade was 24 cases (44{\%}), and 24 cases (44{\%}) were over the fifth decade. Eight patients (15{\%}) had systemic diseases. Especially, diabetes mellitus (DM) occurred only in the adult GGA patients over forty years old. The pathological findings showed dermal granulomatous lesions that consisted of either a palisading pattern (28, 52{\%}) or an interstitial pattern (26,48{\%}). Conclusion: In contrast to the previously reported studies, the age of GGA onset showed a bimodal distribution, and GGA was observed more often in males. The prevalence of DM in the GGA affected individuals was higher than that found in the general Korean population. Therefore, it is recommended to perform a work-up for DM in the GGA affected patients who are over forty years old. (Ann Dermatol 21(2) 113∼119, 2009).",
author = "Yun, {Jeong Hyun} and Lee, {Ji Yeoun} and Kim, {Mi Kyeong} and Seo, {Young Joon} and Kim, {Myung Hwa} and Cho, {Kwang Hyun} and Kim, {Moon Bum} and Lee, {Won Soo} and Kwanghoon Lee and Kim, {You Chan} and Lee, {Seok Jong} and Choi, {Gwang Seong} and Won, {Young Ho} and Ihm, {Chull Wan} and Yoon, {Tae Young}",
year = "2009",
month = "12",
day = "1",
doi = "10.5021/ad.2009.21.2.113",
language = "English",
volume = "21",
pages = "113--119",
journal = "Annals of Dermatology",
issn = "1013-9087",
publisher = "Korean Dermatological Association",
number = "2",

}

Yun, JH, Lee, JY, Kim, MK, Seo, YJ, Kim, MH, Cho, KH, Kim, MB, Lee, WS, Lee, K, Kim, YC, Lee, SJ, Choi, GS, Won, YH, Ihm, CW & Yoon, TY 2009, 'Clinical and pathological features of generalized granuloma annulare with their correlation: A retrospective multicenter study in Korea', Annals of Dermatology, vol. 21, no. 2, pp. 113-119. https://doi.org/10.5021/ad.2009.21.2.113

Clinical and pathological features of generalized granuloma annulare with their correlation : A retrospective multicenter study in Korea. / Yun, Jeong Hyun; Lee, Ji Yeoun; Kim, Mi Kyeong; Seo, Young Joon; Kim, Myung Hwa; Cho, Kwang Hyun; Kim, Moon Bum; Lee, Won Soo; Lee, Kwanghoon; Kim, You Chan; Lee, Seok Jong; Choi, Gwang Seong; Won, Young Ho; Ihm, Chull Wan; Yoon, Tae Young.

In: Annals of Dermatology, Vol. 21, No. 2, 01.12.2009, p. 113-119.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Clinical and pathological features of generalized granuloma annulare with their correlation

T2 - A retrospective multicenter study in Korea

AU - Yun, Jeong Hyun

AU - Lee, Ji Yeoun

AU - Kim, Mi Kyeong

AU - Seo, Young Joon

AU - Kim, Myung Hwa

AU - Cho, Kwang Hyun

AU - Kim, Moon Bum

AU - Lee, Won Soo

AU - Lee, Kwanghoon

AU - Kim, You Chan

AU - Lee, Seok Jong

AU - Choi, Gwang Seong

AU - Won, Young Ho

AU - Ihm, Chull Wan

AU - Yoon, Tae Young

PY - 2009/12/1

Y1 - 2009/12/1

N2 - Background: Generalized granuloma annulare (GGA) is a benign skin disorder of an unknown etiology. Though some cases of GGA have been reported, few systemic reviews of the clinical and pathological features of GGA have been performed. Objective: The purpose of this study is to analyze and correlate the clinical and pathological characteristics of GGA in Korean patients. Methods: We conducted a retrospective study that included 54 biopsy specimens of Korean GGA patients, and the clinical and pathological features of GGA were reviewed and analyzed for their correlation. Results: The cutaneous lesions could be divided into the annular (24, 44%) and nonannular types (30, 56%), and the esions were more common in males than in females (29 males and 25 females). The incidence of GGA showed a bimodal age distribution. The number of patients who prented within the first decade was 24 cases (44%), and 24 cases (44%) were over the fifth decade. Eight patients (15%) had systemic diseases. Especially, diabetes mellitus (DM) occurred only in the adult GGA patients over forty years old. The pathological findings showed dermal granulomatous lesions that consisted of either a palisading pattern (28, 52%) or an interstitial pattern (26,48%). Conclusion: In contrast to the previously reported studies, the age of GGA onset showed a bimodal distribution, and GGA was observed more often in males. The prevalence of DM in the GGA affected individuals was higher than that found in the general Korean population. Therefore, it is recommended to perform a work-up for DM in the GGA affected patients who are over forty years old. (Ann Dermatol 21(2) 113∼119, 2009).

AB - Background: Generalized granuloma annulare (GGA) is a benign skin disorder of an unknown etiology. Though some cases of GGA have been reported, few systemic reviews of the clinical and pathological features of GGA have been performed. Objective: The purpose of this study is to analyze and correlate the clinical and pathological characteristics of GGA in Korean patients. Methods: We conducted a retrospective study that included 54 biopsy specimens of Korean GGA patients, and the clinical and pathological features of GGA were reviewed and analyzed for their correlation. Results: The cutaneous lesions could be divided into the annular (24, 44%) and nonannular types (30, 56%), and the esions were more common in males than in females (29 males and 25 females). The incidence of GGA showed a bimodal age distribution. The number of patients who prented within the first decade was 24 cases (44%), and 24 cases (44%) were over the fifth decade. Eight patients (15%) had systemic diseases. Especially, diabetes mellitus (DM) occurred only in the adult GGA patients over forty years old. The pathological findings showed dermal granulomatous lesions that consisted of either a palisading pattern (28, 52%) or an interstitial pattern (26,48%). Conclusion: In contrast to the previously reported studies, the age of GGA onset showed a bimodal distribution, and GGA was observed more often in males. The prevalence of DM in the GGA affected individuals was higher than that found in the general Korean population. Therefore, it is recommended to perform a work-up for DM in the GGA affected patients who are over forty years old. (Ann Dermatol 21(2) 113∼119, 2009).

UR - http://www.scopus.com/inward/record.url?scp=73449119933&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=73449119933&partnerID=8YFLogxK

U2 - 10.5021/ad.2009.21.2.113

DO - 10.5021/ad.2009.21.2.113

M3 - Article

VL - 21

SP - 113

EP - 119

JO - Annals of Dermatology

JF - Annals of Dermatology

SN - 1013-9087

IS - 2

ER -