Clinical assessment of lipid profiles in live kidney donors

Y. E. Yoon, K. H. Choi, K. H. Kim, S. C. Yang, WoongKyu Han

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Background Abnormal serum lipid profiles are an issue in chronic kidney disease (CKD), but the clinical ramifications of dyslipidemia in live kidney donors are unclear. Thus, we explored the relationship between serum lipids and residual renal function in living donors post-nephrectomy. Methods Charts of living donors who underwent nephrectomy between January 2010 and March 2013 were reviewed, targeting those with 6-month follow-up examinations at minimum. Altogether, 282 donors were studied, examining total cholesterol (TC), triglyceride (TG), low-density lipoprotein (LDL), and high-density lipoprotein (HDL) levels assayed before donation by standard techniques. Median follow-up time was 14 months. The relationship between postoperative renal function and allograft biopsy results was assessed. Recursive partitioning was applied to identify optimal cut-off points for each parameter. Results Median (interquartile range) serum TC, TG, LDL, and HDL levels were 183 (161-205) mg/dL, 86 (63-131) mg/dL, 108 (92-128) mg/dL, and 53 (44-62) mg/dL, respectively. The glomerular filtration rate at last follow-up was associated with TC (r = -0.187; P =.002) and LDL (r = -0.172; P =.005) levels, but showed no correlation with TG and HDL. Root nodes of TC and LDL determinations in recursive partitioning were 170.5 mg/dL and 80.5 mg/dL, respectively, serving as thresholds for further evaluation. On logistic regression analysis, the likelihood of CKD (glomerular filtration rate < 60 mL/min/1.73 m 2 ) at last follow-up was greater in donors with elevated TC and LDL levels (odds ratio = 1.96 and 3.33; P =.021 and.029, respectively). Conclusion Kidney donors with serum TC and LDL elevations require close observation, given their demonstrable predisposition to CKD after donation.

Original languageEnglish
Pages (from-to)584-587
Number of pages4
JournalTransplantation Proceedings
Volume47
Issue number3
DOIs
Publication statusPublished - 2015 Apr 1

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LDL Cholesterol
HDL Lipoproteins
Chronic Renal Insufficiency
Tissue Donors
Kidney
Lipids
Living Donors
Nephrectomy
Serum
Glomerular Filtration Rate
LDL Lipoproteins
Dyslipidemias
Hypercholesterolemia
Allografts
Triglycerides
Logistic Models
Odds Ratio
Cholesterol
Regression Analysis
Observation

All Science Journal Classification (ASJC) codes

  • Surgery
  • Transplantation

Cite this

Yoon, Y. E. ; Choi, K. H. ; Kim, K. H. ; Yang, S. C. ; Han, WoongKyu. / Clinical assessment of lipid profiles in live kidney donors. In: Transplantation Proceedings. 2015 ; Vol. 47, No. 3. pp. 584-587.
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Clinical assessment of lipid profiles in live kidney donors. / Yoon, Y. E.; Choi, K. H.; Kim, K. H.; Yang, S. C.; Han, WoongKyu.

In: Transplantation Proceedings, Vol. 47, No. 3, 01.04.2015, p. 584-587.

Research output: Contribution to journalArticle

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T1 - Clinical assessment of lipid profiles in live kidney donors

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AU - Choi, K. H.

AU - Kim, K. H.

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N2 - Background Abnormal serum lipid profiles are an issue in chronic kidney disease (CKD), but the clinical ramifications of dyslipidemia in live kidney donors are unclear. Thus, we explored the relationship between serum lipids and residual renal function in living donors post-nephrectomy. Methods Charts of living donors who underwent nephrectomy between January 2010 and March 2013 were reviewed, targeting those with 6-month follow-up examinations at minimum. Altogether, 282 donors were studied, examining total cholesterol (TC), triglyceride (TG), low-density lipoprotein (LDL), and high-density lipoprotein (HDL) levels assayed before donation by standard techniques. Median follow-up time was 14 months. The relationship between postoperative renal function and allograft biopsy results was assessed. Recursive partitioning was applied to identify optimal cut-off points for each parameter. Results Median (interquartile range) serum TC, TG, LDL, and HDL levels were 183 (161-205) mg/dL, 86 (63-131) mg/dL, 108 (92-128) mg/dL, and 53 (44-62) mg/dL, respectively. The glomerular filtration rate at last follow-up was associated with TC (r = -0.187; P =.002) and LDL (r = -0.172; P =.005) levels, but showed no correlation with TG and HDL. Root nodes of TC and LDL determinations in recursive partitioning were 170.5 mg/dL and 80.5 mg/dL, respectively, serving as thresholds for further evaluation. On logistic regression analysis, the likelihood of CKD (glomerular filtration rate < 60 mL/min/1.73 m 2 ) at last follow-up was greater in donors with elevated TC and LDL levels (odds ratio = 1.96 and 3.33; P =.021 and.029, respectively). Conclusion Kidney donors with serum TC and LDL elevations require close observation, given their demonstrable predisposition to CKD after donation.

AB - Background Abnormal serum lipid profiles are an issue in chronic kidney disease (CKD), but the clinical ramifications of dyslipidemia in live kidney donors are unclear. Thus, we explored the relationship between serum lipids and residual renal function in living donors post-nephrectomy. Methods Charts of living donors who underwent nephrectomy between January 2010 and March 2013 were reviewed, targeting those with 6-month follow-up examinations at minimum. Altogether, 282 donors were studied, examining total cholesterol (TC), triglyceride (TG), low-density lipoprotein (LDL), and high-density lipoprotein (HDL) levels assayed before donation by standard techniques. Median follow-up time was 14 months. The relationship between postoperative renal function and allograft biopsy results was assessed. Recursive partitioning was applied to identify optimal cut-off points for each parameter. Results Median (interquartile range) serum TC, TG, LDL, and HDL levels were 183 (161-205) mg/dL, 86 (63-131) mg/dL, 108 (92-128) mg/dL, and 53 (44-62) mg/dL, respectively. The glomerular filtration rate at last follow-up was associated with TC (r = -0.187; P =.002) and LDL (r = -0.172; P =.005) levels, but showed no correlation with TG and HDL. Root nodes of TC and LDL determinations in recursive partitioning were 170.5 mg/dL and 80.5 mg/dL, respectively, serving as thresholds for further evaluation. On logistic regression analysis, the likelihood of CKD (glomerular filtration rate < 60 mL/min/1.73 m 2 ) at last follow-up was greater in donors with elevated TC and LDL levels (odds ratio = 1.96 and 3.33; P =.021 and.029, respectively). Conclusion Kidney donors with serum TC and LDL elevations require close observation, given their demonstrable predisposition to CKD after donation.

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