Clinical benefit of spironolactone in patients with acute decompensated heart failure and severe renal dysfunction: Data from the Korean Heart Failure Registry

Jaewon Oh, Seok Min Kang, Mi Kyung Song, Namki Hong, Jong Chan Youn, Seongwoo Han, Eun Seok Jeon, Myeong Chan Cho, Jae Joong Kim, Byung Su Yoo, Shung Chull Chae, Byung Hee Oh, Dong Ju Choi, Myung Mook Lee, Kyu Hyung Ryu

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Abstract

Backgrounds We investigated the relationship between spironolactone use and all-cause mortality in acute decompensated heart failure (ADHF) patients with severe renal dysfunction. The clinical benefit of spironolactone in the treatment of heart failure (HF) has been described in several large randomized clinical trials. However, its clinical benefits have not been studied in hospitalized ADHF patients with severe renal dysfunction (estimated glomerular filtration rate [eGFR] <45 mL/min per 1.73 m2). Methods and results We retrospectively analyzed data from the Korean Heart Failure Registry. We included 1,035 ADHF patients with severe renal dysfunction. In Kaplan-Meier survival analysis, all-cause mortality in the spironolactone-treated group was significantly lower than that in the nonspironolactone group (18.1% vs 24.9%, respectively, log rank P =.028). However, spironolactone use was not an independent predictor after adjusting other HF risk factors (hazard ratio 0.974, 95% CI 0.681-1.392, P =.884) and after propensity score matching (P =.115). In subgroup analysis, the clinical benefit of spironolactone use was preserved in women, prehospital spironolactone use, the chronic kidney disease stage 3b (eGFR 30-44 mL/min per 1.73 m2), and the appropriate spironolactone use (eGFR ≥30 mL/min per 1.73 m2 and K >5.0 mmol/L). Conclusion The spironolactone therapy was not beneficial in ADHF patients with severe renal dysfunction after multivariable adjusting and propensity score matching. However, we reassured the current HF guidelines for spironolactone use and the clinical benefit in chronic kidney disease stage 3b should be assessed in future clinical trial.

Original languageEnglish
Pages (from-to)713-720.e3
JournalAmerican heart journal
Volume169
Issue number5
DOIs
Publication statusPublished - 2015 May 1

All Science Journal Classification (ASJC) codes

  • Cardiology and Cardiovascular Medicine

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    Oh, J., Kang, S. M., Song, M. K., Hong, N., Youn, J. C., Han, S., Jeon, E. S., Cho, M. C., Kim, J. J., Yoo, B. S., Chae, S. C., Oh, B. H., Choi, D. J., Lee, M. M., & Ryu, K. H. (2015). Clinical benefit of spironolactone in patients with acute decompensated heart failure and severe renal dysfunction: Data from the Korean Heart Failure Registry. American heart journal, 169(5), 713-720.e3. https://doi.org/10.1016/j.ahj.2015.01.014