Clinical characteristics & outcome of acute heart failure in Korea: Results from the Korean acute heart failure registry (KorAHF)

Sang Eun Lee, Hae Young Lee, Hyun Jai Cho, Won Seok Choe, Hokon Kim, Jin Oh Choi, Eun Seok Jeon, Min Seok Kim, Jae Joong Kim, Kyung Kuk Hwang, Shung Chull Chae, Sang Hong Baek, Seok Min Kang, Dong Ju Choi, Byung Su Yoo, Kye Hun Kim, Hyun Young Park, Myeong Chan Cho, Byung Hee Oh

Research output: Contribution to journalArticle

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Abstract

Background and Objectives: The burden of heart failure has increased in Korea. This registry aims to evaluate demographics, clinical characteristics, management, and long-Term outcomes in patients hospitalized for acute heart failure (AHF). Subjects and Methods: We prospectively enrolled a total of 5625 consecutive subjects hospitalized for AHF in one of 10 tertiary university hospitals from March 2011 to February 2014. Descriptive statistics were used to determine the baseline characteristics of the study population and to compare them with those from other registries. Results: The mean age was 68.5±14.5 years, 53.2% were male, and 52.2% had de novo heart failure. The mean systolic and diastolic blood pressures were 131.2±30.3 mmHg and 78.6±18.8 mmHg at admission, respectively. The left ventricular ejection fraction was ≤40% in 60.5% of patients. Ischemia was the most frequent etiology (37.6%) and aggravating factor (26.3%). Angiotensin converting enzyme inhibitors/ angiotensin receptor blockers, beta-blockers, and aldosterone antagonists were prescribed in 68.8%, 52.2%, and 46.6% of the patients at discharge, respectively. Compared with the previous registry performed in Korea a decade ago, extracorporeal membrane oxygenation (ECMO) and heart transplantation have been performed more frequently (ECMO 0.8% vs. 2.8%, heart transplantation 0.3% vs. 1.2%), and in-hospital mortality decreased from 7.6% to 4.8%. However, the total cost of hospital care increased by 40%, and one-year follow-up mortality remained high. Conclusion: While the quality of acute clinical care and AHF-related outcomes have improved over the last decade, the long-Term prognosis of heart failure is still poor in Korea. Therefore, additional research is needed to improve long-Term outcomes and implement cost-effective care.

Original languageEnglish
Pages (from-to)341-353
Number of pages13
JournalKorean Circulation Journal
Volume47
Issue number3
DOIs
Publication statusPublished - 2017 May

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Korea
Registries
Heart Failure
Extracorporeal Membrane Oxygenation
Heart Transplantation
Blood Pressure
Mineralocorticoid Receptor Antagonists
Patient Discharge
Hospital Costs
Angiotensin Receptor Antagonists
Population Characteristics
Hospital Mortality
Angiotensin-Converting Enzyme Inhibitors
Tertiary Care Centers
Stroke Volume
Ischemia
Demography
Costs and Cost Analysis
Mortality
Research

All Science Journal Classification (ASJC) codes

  • Internal Medicine
  • Cardiology and Cardiovascular Medicine

Cite this

Lee, Sang Eun ; Lee, Hae Young ; Cho, Hyun Jai ; Choe, Won Seok ; Kim, Hokon ; Choi, Jin Oh ; Jeon, Eun Seok ; Kim, Min Seok ; Kim, Jae Joong ; Hwang, Kyung Kuk ; Chae, Shung Chull ; Baek, Sang Hong ; Kang, Seok Min ; Choi, Dong Ju ; Yoo, Byung Su ; Kim, Kye Hun ; Park, Hyun Young ; Cho, Myeong Chan ; Oh, Byung Hee. / Clinical characteristics & outcome of acute heart failure in Korea : Results from the Korean acute heart failure registry (KorAHF). In: Korean Circulation Journal. 2017 ; Vol. 47, No. 3. pp. 341-353.
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title = "Clinical characteristics & outcome of acute heart failure in Korea: Results from the Korean acute heart failure registry (KorAHF)",
abstract = "Background and Objectives: The burden of heart failure has increased in Korea. This registry aims to evaluate demographics, clinical characteristics, management, and long-Term outcomes in patients hospitalized for acute heart failure (AHF). Subjects and Methods: We prospectively enrolled a total of 5625 consecutive subjects hospitalized for AHF in one of 10 tertiary university hospitals from March 2011 to February 2014. Descriptive statistics were used to determine the baseline characteristics of the study population and to compare them with those from other registries. Results: The mean age was 68.5±14.5 years, 53.2{\%} were male, and 52.2{\%} had de novo heart failure. The mean systolic and diastolic blood pressures were 131.2±30.3 mmHg and 78.6±18.8 mmHg at admission, respectively. The left ventricular ejection fraction was ≤40{\%} in 60.5{\%} of patients. Ischemia was the most frequent etiology (37.6{\%}) and aggravating factor (26.3{\%}). Angiotensin converting enzyme inhibitors/ angiotensin receptor blockers, beta-blockers, and aldosterone antagonists were prescribed in 68.8{\%}, 52.2{\%}, and 46.6{\%} of the patients at discharge, respectively. Compared with the previous registry performed in Korea a decade ago, extracorporeal membrane oxygenation (ECMO) and heart transplantation have been performed more frequently (ECMO 0.8{\%} vs. 2.8{\%}, heart transplantation 0.3{\%} vs. 1.2{\%}), and in-hospital mortality decreased from 7.6{\%} to 4.8{\%}. However, the total cost of hospital care increased by 40{\%}, and one-year follow-up mortality remained high. Conclusion: While the quality of acute clinical care and AHF-related outcomes have improved over the last decade, the long-Term prognosis of heart failure is still poor in Korea. Therefore, additional research is needed to improve long-Term outcomes and implement cost-effective care.",
author = "Lee, {Sang Eun} and Lee, {Hae Young} and Cho, {Hyun Jai} and Choe, {Won Seok} and Hokon Kim and Choi, {Jin Oh} and Jeon, {Eun Seok} and Kim, {Min Seok} and Kim, {Jae Joong} and Hwang, {Kyung Kuk} and Chae, {Shung Chull} and Baek, {Sang Hong} and Kang, {Seok Min} and Choi, {Dong Ju} and Yoo, {Byung Su} and Kim, {Kye Hun} and Park, {Hyun Young} and Cho, {Myeong Chan} and Oh, {Byung Hee}",
year = "2017",
month = "5",
doi = "10.4070/kcj.2016.0419",
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Lee, SE, Lee, HY, Cho, HJ, Choe, WS, Kim, H, Choi, JO, Jeon, ES, Kim, MS, Kim, JJ, Hwang, KK, Chae, SC, Baek, SH, Kang, SM, Choi, DJ, Yoo, BS, Kim, KH, Park, HY, Cho, MC & Oh, BH 2017, 'Clinical characteristics & outcome of acute heart failure in Korea: Results from the Korean acute heart failure registry (KorAHF)', Korean Circulation Journal, vol. 47, no. 3, pp. 341-353. https://doi.org/10.4070/kcj.2016.0419

Clinical characteristics & outcome of acute heart failure in Korea : Results from the Korean acute heart failure registry (KorAHF). / Lee, Sang Eun; Lee, Hae Young; Cho, Hyun Jai; Choe, Won Seok; Kim, Hokon; Choi, Jin Oh; Jeon, Eun Seok; Kim, Min Seok; Kim, Jae Joong; Hwang, Kyung Kuk; Chae, Shung Chull; Baek, Sang Hong; Kang, Seok Min; Choi, Dong Ju; Yoo, Byung Su; Kim, Kye Hun; Park, Hyun Young; Cho, Myeong Chan; Oh, Byung Hee.

In: Korean Circulation Journal, Vol. 47, No. 3, 05.2017, p. 341-353.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Clinical characteristics & outcome of acute heart failure in Korea

T2 - Results from the Korean acute heart failure registry (KorAHF)

AU - Lee, Sang Eun

AU - Lee, Hae Young

AU - Cho, Hyun Jai

AU - Choe, Won Seok

AU - Kim, Hokon

AU - Choi, Jin Oh

AU - Jeon, Eun Seok

AU - Kim, Min Seok

AU - Kim, Jae Joong

AU - Hwang, Kyung Kuk

AU - Chae, Shung Chull

AU - Baek, Sang Hong

AU - Kang, Seok Min

AU - Choi, Dong Ju

AU - Yoo, Byung Su

AU - Kim, Kye Hun

AU - Park, Hyun Young

AU - Cho, Myeong Chan

AU - Oh, Byung Hee

PY - 2017/5

Y1 - 2017/5

N2 - Background and Objectives: The burden of heart failure has increased in Korea. This registry aims to evaluate demographics, clinical characteristics, management, and long-Term outcomes in patients hospitalized for acute heart failure (AHF). Subjects and Methods: We prospectively enrolled a total of 5625 consecutive subjects hospitalized for AHF in one of 10 tertiary university hospitals from March 2011 to February 2014. Descriptive statistics were used to determine the baseline characteristics of the study population and to compare them with those from other registries. Results: The mean age was 68.5±14.5 years, 53.2% were male, and 52.2% had de novo heart failure. The mean systolic and diastolic blood pressures were 131.2±30.3 mmHg and 78.6±18.8 mmHg at admission, respectively. The left ventricular ejection fraction was ≤40% in 60.5% of patients. Ischemia was the most frequent etiology (37.6%) and aggravating factor (26.3%). Angiotensin converting enzyme inhibitors/ angiotensin receptor blockers, beta-blockers, and aldosterone antagonists were prescribed in 68.8%, 52.2%, and 46.6% of the patients at discharge, respectively. Compared with the previous registry performed in Korea a decade ago, extracorporeal membrane oxygenation (ECMO) and heart transplantation have been performed more frequently (ECMO 0.8% vs. 2.8%, heart transplantation 0.3% vs. 1.2%), and in-hospital mortality decreased from 7.6% to 4.8%. However, the total cost of hospital care increased by 40%, and one-year follow-up mortality remained high. Conclusion: While the quality of acute clinical care and AHF-related outcomes have improved over the last decade, the long-Term prognosis of heart failure is still poor in Korea. Therefore, additional research is needed to improve long-Term outcomes and implement cost-effective care.

AB - Background and Objectives: The burden of heart failure has increased in Korea. This registry aims to evaluate demographics, clinical characteristics, management, and long-Term outcomes in patients hospitalized for acute heart failure (AHF). Subjects and Methods: We prospectively enrolled a total of 5625 consecutive subjects hospitalized for AHF in one of 10 tertiary university hospitals from March 2011 to February 2014. Descriptive statistics were used to determine the baseline characteristics of the study population and to compare them with those from other registries. Results: The mean age was 68.5±14.5 years, 53.2% were male, and 52.2% had de novo heart failure. The mean systolic and diastolic blood pressures were 131.2±30.3 mmHg and 78.6±18.8 mmHg at admission, respectively. The left ventricular ejection fraction was ≤40% in 60.5% of patients. Ischemia was the most frequent etiology (37.6%) and aggravating factor (26.3%). Angiotensin converting enzyme inhibitors/ angiotensin receptor blockers, beta-blockers, and aldosterone antagonists were prescribed in 68.8%, 52.2%, and 46.6% of the patients at discharge, respectively. Compared with the previous registry performed in Korea a decade ago, extracorporeal membrane oxygenation (ECMO) and heart transplantation have been performed more frequently (ECMO 0.8% vs. 2.8%, heart transplantation 0.3% vs. 1.2%), and in-hospital mortality decreased from 7.6% to 4.8%. However, the total cost of hospital care increased by 40%, and one-year follow-up mortality remained high. Conclusion: While the quality of acute clinical care and AHF-related outcomes have improved over the last decade, the long-Term prognosis of heart failure is still poor in Korea. Therefore, additional research is needed to improve long-Term outcomes and implement cost-effective care.

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