Clinical characteristics and prognosis of lymphocyte dominant exudative pleural effusion with low ADA, low CEA, negative cytology and negative AFB smear

youngae kang, Young Soon Yoon, Sei Won Lee, Chang Min Choi, Deog Kyeom Kim, Hee Seok Lee, Dong Seok Ko, Chul Gyu Yoo, Young Whan Kim, Sung Koo Man, Young Soo Shim, Jae Joon Yim

Research output: Contribution to journalArticle

Abstract

Background: A pleural effusion is a common medical problem. Despite several diagnostic tests, 15-20% of pleural effusions go undiagnosed. The aim of this study was to evaluate the clinical characteristics and prognosis of a lymphocyte dominant exudative pleural effusion with a low adenosine deaminase (ADA), low carcinoembryonic antigen (CEA), negative cytology and negative acid fast bacilli (AFB) smear. Method: From Jan 2000 to Aug 2001, 43 patients with lymphocyte dominant exudative pleural effusions whose AFB smear and cytologic exam were negative, their pleural fluid ADA level was < 40 IU/L, and their CEA level was < 10 ng/mL were enrolled in this study. A retrospective analysis of the patients' medical records was carried out. Result: Among 31 of the 43 cases (72%), probable underlying diseases causing the pleural effusion were identified: 21cases of malignant diseases, 4 cases of liver cirrhosis, 2 cases of pulmonary tuberculosis, 1 case of end stage renal disease, 1 case of a chylothorax, 1 case of a post CABG (coronary artery bypass graft) state, 1 case of a pulmonary embolism. No clinically suspected etiology was identified in the remaining 12 cases (28%). Of these 12 pleural effusions, 7 cases spontaneously resolved, 2 effusions resolved with antibiotics, and the other 2 cases were persistent. Conclusion: Lymphocyte dominant exudative pleural effusions with a low ADA, low CEA, negative cytological exam, and negative AFB smear, but without a definite cause might have a benign course and clinicians can observe them with attention.

Original languageEnglish
Pages (from-to)5-10
Number of pages6
JournalTuberculosis and Respiratory Diseases
Volume58
Issue number1
Publication statusPublished - 2005 Jan 1

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Adenosine Deaminase
Carcinoembryonic Antigen
Pleural Effusion
Bacillus
Cell Biology
Lymphocytes
Acids
Chylothorax
Pulmonary Embolism
Pulmonary Tuberculosis
Routine Diagnostic Tests
Coronary Artery Bypass
Liver Cirrhosis
Chronic Kidney Failure
Medical Records
Anti-Bacterial Agents
Transplants

All Science Journal Classification (ASJC) codes

  • Pulmonary and Respiratory Medicine
  • Infectious Diseases

Cite this

kang, youngae ; Yoon, Young Soon ; Lee, Sei Won ; Choi, Chang Min ; Kim, Deog Kyeom ; Lee, Hee Seok ; Ko, Dong Seok ; Yoo, Chul Gyu ; Kim, Young Whan ; Man, Sung Koo ; Shim, Young Soo ; Yim, Jae Joon. / Clinical characteristics and prognosis of lymphocyte dominant exudative pleural effusion with low ADA, low CEA, negative cytology and negative AFB smear. In: Tuberculosis and Respiratory Diseases. 2005 ; Vol. 58, No. 1. pp. 5-10.
@article{9c62c79e73a1448bbde85351d822c2af,
title = "Clinical characteristics and prognosis of lymphocyte dominant exudative pleural effusion with low ADA, low CEA, negative cytology and negative AFB smear",
abstract = "Background: A pleural effusion is a common medical problem. Despite several diagnostic tests, 15-20{\%} of pleural effusions go undiagnosed. The aim of this study was to evaluate the clinical characteristics and prognosis of a lymphocyte dominant exudative pleural effusion with a low adenosine deaminase (ADA), low carcinoembryonic antigen (CEA), negative cytology and negative acid fast bacilli (AFB) smear. Method: From Jan 2000 to Aug 2001, 43 patients with lymphocyte dominant exudative pleural effusions whose AFB smear and cytologic exam were negative, their pleural fluid ADA level was < 40 IU/L, and their CEA level was < 10 ng/mL were enrolled in this study. A retrospective analysis of the patients' medical records was carried out. Result: Among 31 of the 43 cases (72{\%}), probable underlying diseases causing the pleural effusion were identified: 21cases of malignant diseases, 4 cases of liver cirrhosis, 2 cases of pulmonary tuberculosis, 1 case of end stage renal disease, 1 case of a chylothorax, 1 case of a post CABG (coronary artery bypass graft) state, 1 case of a pulmonary embolism. No clinically suspected etiology was identified in the remaining 12 cases (28{\%}). Of these 12 pleural effusions, 7 cases spontaneously resolved, 2 effusions resolved with antibiotics, and the other 2 cases were persistent. Conclusion: Lymphocyte dominant exudative pleural effusions with a low ADA, low CEA, negative cytological exam, and negative AFB smear, but without a definite cause might have a benign course and clinicians can observe them with attention.",
author = "youngae kang and Yoon, {Young Soon} and Lee, {Sei Won} and Choi, {Chang Min} and Kim, {Deog Kyeom} and Lee, {Hee Seok} and Ko, {Dong Seok} and Yoo, {Chul Gyu} and Kim, {Young Whan} and Man, {Sung Koo} and Shim, {Young Soo} and Yim, {Jae Joon}",
year = "2005",
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kang, Y, Yoon, YS, Lee, SW, Choi, CM, Kim, DK, Lee, HS, Ko, DS, Yoo, CG, Kim, YW, Man, SK, Shim, YS & Yim, JJ 2005, 'Clinical characteristics and prognosis of lymphocyte dominant exudative pleural effusion with low ADA, low CEA, negative cytology and negative AFB smear', Tuberculosis and Respiratory Diseases, vol. 58, no. 1, pp. 5-10.

Clinical characteristics and prognosis of lymphocyte dominant exudative pleural effusion with low ADA, low CEA, negative cytology and negative AFB smear. / kang, youngae; Yoon, Young Soon; Lee, Sei Won; Choi, Chang Min; Kim, Deog Kyeom; Lee, Hee Seok; Ko, Dong Seok; Yoo, Chul Gyu; Kim, Young Whan; Man, Sung Koo; Shim, Young Soo; Yim, Jae Joon.

In: Tuberculosis and Respiratory Diseases, Vol. 58, No. 1, 01.01.2005, p. 5-10.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Clinical characteristics and prognosis of lymphocyte dominant exudative pleural effusion with low ADA, low CEA, negative cytology and negative AFB smear

AU - kang, youngae

AU - Yoon, Young Soon

AU - Lee, Sei Won

AU - Choi, Chang Min

AU - Kim, Deog Kyeom

AU - Lee, Hee Seok

AU - Ko, Dong Seok

AU - Yoo, Chul Gyu

AU - Kim, Young Whan

AU - Man, Sung Koo

AU - Shim, Young Soo

AU - Yim, Jae Joon

PY - 2005/1/1

Y1 - 2005/1/1

N2 - Background: A pleural effusion is a common medical problem. Despite several diagnostic tests, 15-20% of pleural effusions go undiagnosed. The aim of this study was to evaluate the clinical characteristics and prognosis of a lymphocyte dominant exudative pleural effusion with a low adenosine deaminase (ADA), low carcinoembryonic antigen (CEA), negative cytology and negative acid fast bacilli (AFB) smear. Method: From Jan 2000 to Aug 2001, 43 patients with lymphocyte dominant exudative pleural effusions whose AFB smear and cytologic exam were negative, their pleural fluid ADA level was < 40 IU/L, and their CEA level was < 10 ng/mL were enrolled in this study. A retrospective analysis of the patients' medical records was carried out. Result: Among 31 of the 43 cases (72%), probable underlying diseases causing the pleural effusion were identified: 21cases of malignant diseases, 4 cases of liver cirrhosis, 2 cases of pulmonary tuberculosis, 1 case of end stage renal disease, 1 case of a chylothorax, 1 case of a post CABG (coronary artery bypass graft) state, 1 case of a pulmonary embolism. No clinically suspected etiology was identified in the remaining 12 cases (28%). Of these 12 pleural effusions, 7 cases spontaneously resolved, 2 effusions resolved with antibiotics, and the other 2 cases were persistent. Conclusion: Lymphocyte dominant exudative pleural effusions with a low ADA, low CEA, negative cytological exam, and negative AFB smear, but without a definite cause might have a benign course and clinicians can observe them with attention.

AB - Background: A pleural effusion is a common medical problem. Despite several diagnostic tests, 15-20% of pleural effusions go undiagnosed. The aim of this study was to evaluate the clinical characteristics and prognosis of a lymphocyte dominant exudative pleural effusion with a low adenosine deaminase (ADA), low carcinoembryonic antigen (CEA), negative cytology and negative acid fast bacilli (AFB) smear. Method: From Jan 2000 to Aug 2001, 43 patients with lymphocyte dominant exudative pleural effusions whose AFB smear and cytologic exam were negative, their pleural fluid ADA level was < 40 IU/L, and their CEA level was < 10 ng/mL were enrolled in this study. A retrospective analysis of the patients' medical records was carried out. Result: Among 31 of the 43 cases (72%), probable underlying diseases causing the pleural effusion were identified: 21cases of malignant diseases, 4 cases of liver cirrhosis, 2 cases of pulmonary tuberculosis, 1 case of end stage renal disease, 1 case of a chylothorax, 1 case of a post CABG (coronary artery bypass graft) state, 1 case of a pulmonary embolism. No clinically suspected etiology was identified in the remaining 12 cases (28%). Of these 12 pleural effusions, 7 cases spontaneously resolved, 2 effusions resolved with antibiotics, and the other 2 cases were persistent. Conclusion: Lymphocyte dominant exudative pleural effusions with a low ADA, low CEA, negative cytological exam, and negative AFB smear, but without a definite cause might have a benign course and clinicians can observe them with attention.

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M3 - Article

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