Clinical Characteristics and Prognostic Factors in Ankylosing Spondylitis Associated Uveitis

Ji Hwan Lee, Moonjung Choi, Tyler Hyung Taek Rim, Sung Chul Lee, Christopher Seungkyu Lee

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Abstract

Purpose: To identify the clinical features and prognostic factors of uveitis associated with ankylosing spondylitis (AS). Methods: This retrospective, interventional case series study reviewed the medical records of 91 AS patients with uveitis. Results: The characteristics of AS-associated uveitis included male preponderance (70%), average onset in the fourth decade, unilateral manifestation (87.9%), and vitreous involvement or retinal vascular leakage (36.3%). All patients had acute anterior uveitis. The best corrected visual acuity in logMAR improved from 0.8 ± 0.3 to 0.1 ± 0.2. The use of biologic agents was the only significant factor in the multivariate analysis. Patients with vitreous involvement/retinal vascular leakage were more likely to use systemic/peribulbar steroids for inflammation control, and achieved equally favorable visual outcome as in those without vitreous involvement/retinal vascular leakage. Conclusion: The clinical characteristics and profile of visual prognostic factors suggest an association between the severity of ocular inflammation and systemic disease.

Original languageEnglish
Pages (from-to)64-69
Number of pages6
JournalOcular Immunology and Inflammation
Volume27
Issue number1
DOIs
Publication statusPublished - 2019 Jan 2

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All Science Journal Classification (ASJC) codes

  • Immunology and Allergy
  • Ophthalmology

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